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郭欢

  • 中文简历English resume
  • 姓名:郭欢
  • 职务:副教授、博导、“万人计划”青年拔尖人才支持计划入选者、全国优秀博士论文获得者
  • 院系:劳动卫生与环境卫生学系
  • 地址:湖北省武汉市航空路13号 430030
  • 电话:
  • 邮箱:ghuan5011@hust.edu.cn

郭欢,女,1984年5月生,副教授,全国优秀博士学位论文获得者,“万人计划”青年拔尖人才支持计划入选者。2005年6月毕业于华中科技大学同济医学院,获得预防医学专业学士学位;同年9月进入华中科技大学公共卫生学院劳动卫生与环境卫生学系进行硕博连读研究生学习,师从导师邬堂春教授,主要研究方向为空气污染与肺癌的分子流行病学;于2010年6月获得医学博士学位,2010年7月于华中科技大学留校工作,并破格升为副教授;2011年被聘任为华中科技大学硕士生及博士生导师;2012年11月至2013年11月在耶鲁大学公卫学院进行一年的访问研究。近五年发表SCI英文论文50余篇,其中以第一作者和共同第一作者身份发表SCI英文论文于国际知名杂志J Clin Oncol(IF=18.43)、Gut(IF=14.66)、Cancer Res(IF=9.33)及Carcinogenesis(IF=5.33)等上,并作为通讯作者将研究成果发表于Environ Sci Technol(IF=5.33)、Sci Rep(IF=5.58)、Mol Carcinog(IF=4.81)等上。研究论文及结果被Nat Genet等杂志正面引用,得到了国内外同行的高度认可和评价,博士论文并评为2012年全国优秀博士学位论文奖;2012年获得华中科技大学学术新人奖,后入选教育部新世纪优秀人才支持计划;2015年入选中组部“万人计划”青年拔尖人才支持计划。目前主持国家自然科学基金项目两项,教育部博士点新教师基金及华中科技大学自主创新基金项目各一项,并作为主要负责人(第三)参与了国家自然科学基金重点项目、973计划、国家科技支撑计划等多项科研课题,为Carcinogenesis、Environ Res、Sci Total Environ、Toxicol Res等杂志审稿人。

 

 

教育经历

2000/09-2005/06 华中科技大学 公共卫生学院 预防医学本科

2005/09-2010/06 华中科技大学 公共卫生学院 劳动卫生与环境卫生学 博士
2007/10-2008/12 中国医学科学院肿瘤研究所 交流学习

 

 

工作经历

2010/07-至今 华中科技大学 公共卫生学院 副教授

2012/11-2013/11 美国耶鲁大学 公共卫生学院 访问副教授

 

 

主持的科研项目

1. 2014年“万人计划”青年拔尖人才支持计划(2016.01-2018.12,190万)

 

2. miRNA在多环芳烃致机体DNA损伤及肺癌发生和预后中的作用与机制(全国优秀博士学位论文作者专项资金,2014084,2014.1-2017.12,50万)

 

3. 教育部新世纪优秀人才支持计划(NCET-12-0209,2013.1-2017.12,50万)

 

4. 细胞周期调控关键基因的肺癌易感位点鉴定及功能分析(国家自然科学基金面上项目,81272589,2013.1-2016.12,70万)

 

5. HSPB1、APEX1和TP53基因遗传变异与焦炉工DNA损伤的关联性研究(国家自然科学基金青年科学基金项目,81102102,2012.1-2014.12,24万)

 

6. HAP1基因遗传变异与焦炉工DNA损伤的关联性研究(教育部博士点学科新教师基金,20110142120026,2012.1-2014.12,4万)

 

7. 微小RNA前体区域遗传变异与焦炉工遗传损伤程度的关联性研究(华中科技大学自主创新研究基金,2011QN207,2011.6-2012.12,5万)

 

 

参与的科研项目

8. Sirt1基因在听觉系统退行性变中的作用机制及干预措施(国家自然科学基金重点项目,81230021,2013.01-2017.12,第三负责人,50/280万)

 

9. 交通尾气污染与社区人群肺功能降低的联系及其机制研究(973计划前期研究专项,2009.04~2012.04,第五负责人)

 

 

10. 大气细颗粒物引发呼吸道损伤的病理生理学机制与干预研究(国家重点基础研究发展计划(973计划),2015CB553400,2015.01~2019.12,第三课题组研究骨干)

 

 

获得奖励

1. 2011年:武汉市自然科学优秀学术论文一等奖

 

2. 2011年:湖北省优秀博士学位论文

 

3. 2012年,华中科技大学“学术新人奖”

 

4. 2012年,全国百篇优秀博士学位论文奖

 

5. 2012年,入选教育部新世纪优秀人才支持计划

 

6. 2015年,入选中组部“万人计划”青年拔尖人才支持计划

 

 

国际国内学术任职

1. 中华预防医学会环境卫生分会青年委员会 副主任委员

 

2. 中国抗癌协会肿瘤病因学专业委员会第一届青年委员会 委员

 

3. 武汉市预防医学会 第五届理事会 理事

 

4. SCI期刊Carcinogenesis、Environ Res、Sci Total Environ、Toxicol Res等杂志审稿人。

 

 

参与的学术会议

1. 2006年、中国武汉、第一届生物医学和环境卫生科学前沿国际会议

 

2. 2009年、中国宜昌、全国肿瘤流行病学和肿瘤病因学学术会议

 

3. 2009年、日本札幌、The 4th Cell Stress Society International (CSSI) Congress on Stress Responses in Biology and Medicine,大会交流,获 Young investigator award.

 

4. 2012年4月7-10日、后基因组关联研究时代面临的挑战与机遇-青年科学家论坛、中国武汉、大会发言

 

5. 2014年8月20-24日、全国第十三次劳动卫生与职业病学术会议、山东泰安、郭欢/李晓亮

 

6. 2014年12月28-30日、2014年东湖国际青年学者论坛、湖北武汉、大会发言

 

7. 2015年8月19-22日、全国肿瘤病因学和肿瘤流行病学成都学术会议、大会发言

 

参与编写:《现代职业卫生与职业医学》(人民卫生出版社,2011.2)

 

参与编写:《中国预防医学百科全书》(待出版)

 

参与编写:国家医学电子书包《卫生学》(待出版)

 

 

代表性论著

通讯作者论文

1. Bai Y, Feng W, Wang S, Zhang X, Zhang W, He M, Zhang X, Wu T, Guo H*. Essential Metals Zinc, Selenium, and Strontium Protect against Chromosome Damage Caused by Polycyclic Aromatic Hydrocarbons Exposure. Environ Sci Technol. 2016, 50(2):951-60. (T2, SCI Impact Factor: 5.33)

 

2. Wang T, Feng W, Kuang D, Deng Q, Zhang W, Wang S, He M, Zhang X, Wu T, Guo H*. The effects of heavy metals and their interactions with polycyclic aromatic hydrocarbons on the oxidative stress among coke-oven workers. Environ Res. 2015, 140: 405-413. (SCI Impact Factor: 4.373)

 

 

3. Dai X, He X, Zhou Z, Chen J, Wei S, Chen R, Yang B, Feng W, Shan A, Wu T, Guo H*. Short-term effects of air pollution on out-of-hospital cardiac arrest in Shenzhen, China. Int J Cardiol. 2015, 192:56-60. (SCI Impact Factor: 4.036)

 

 

4. Li X, Bai Y, Wang S, Nyamathira SM, Zhang X, Zhang W, Wang T, Deng Q, He M, Zhang X, Wu T, Guo H*. Association of body mass index with chromosome damage levels and lung cancer risk among males. Sci Rep. 2015, 5:9458. doi: 10.1038/srep09458. (SCI Impact Factor: 5.578)

 

 

5. Li X, Wei J, Xu P, Yin X, Hu D, Zhang X, Liu L, Zhang K, Zhou C, Wang T, Zhang X, He M, Wu T, Yang M, Guo H*. The interaction of APEX1 variant with polycyclic aromatic hydrocarbons on increasing chromosome damage and lung cancer risk among male Chinese. Mol Carcinog. 2015 Jun; 54 Suppl 1:E103-11. (SCI Impact Factor: 4.808)

 

 

6. Guo H*, Huang K, Zhang X, Zhang W, Guan L, Kuang D, Deng Q, Deng H, Zhang X, He M, Christiani D, Wu T. Women are more susceptible than men to oxidative stress and chromosome damage caused by polycyclic aromatic hydrocarbons exposure. Environ Mol Mutagen. 2014, 55(6):472-81. (SCI Impact Factor: 2.63)

 

 

7. Xin L, Wang J, Guo S, Wu Y, Li X, Deng H, Kuang D, Xiao W, Wu T, Guo H*. Organic extracts of coke oven emissions can induce genetic damage in metabolically competent HepG2 cells. Environ Toxicol Phar. 2014, 37(3):946-53. (SCI Impact Factor: 2.084)

 

 

8. Kuang D, Zhang W, Deng Q, Zhang X, Huang K, Guan L, Hu D, Wu T, Guo H*. Dose-response relationships of polycyclic aromatic hydrocarbons exposure and oxidative damage to DNA and lipid in coke oven workers. Environ Sci Technol. 2013, 47(13):7446-56. (T2, SCI Impact Factor: 5.33)

 

 

9. Xu P, Liu L, Wang J, Zhang K, Hong X, Deng Q, Xiang J, Zhang X, He M, Wu T, Guo H*. Genetic variation in BCL2 3’-UTR was associated with lung cancer risk and prognosis in male Chinese population. PLoS One. 2013, 8(8):e72197. (SCI Impact Factor: 3.234)

 

第一和共同第一作者论文

10. Liu C, Guo H*, Cheng X, Shao M, Wu C, Wang S, Li H, Wei L, Gao Y, Tan W, Cheng S, Wu T*, Yu D*, Lin D*. Exposure to airborne PM2.5 suppresses microRNA expression and deregulates target oncogenes that cause neoplastic transformation in NIH3T3 cells. Oncotarget. 2015 Oct 6;6(30):29428-39. (*Co-first author) (SCI Impact Factor: 6.359)

 

 

11. Guo H, Jin Y, Cheng Y, Leaderer B, Lin S, Holford TR, Qiu J, Zhang Y, Shi K, Zhu Y, Niu J, Bassig BA, Xu S, Zhang B, Li Y, Hu X, Chen Q, Zheng T. Prenatal exposure to organochlorine pesticides and infant birth weight in China. Chemosphere. 2014, 110:1-7. (SCI Impact Factor: 3.34)

 

 

12. Guo H, Bassig BA, Lan Q, Zhu Y, Zhang Y, Holford TR, Leaderer B, Boyle P, Qin Q, Zhu C, Li N, Rothman N, Zheng T. Polymorphisms in DNA repair genes, hair dye use, and the risk of non-Hodgkin lymphoma. Cancer Causes Control. 2014, 25(10):1261-70. (SCI Impact Factor: 2.735)

 

 

13. He M, Wu C, Xu J, Guo H*, Yang H, Zhang X, Sun J, Yu D, Zhou L, Peng T, He Y, Gao Y, Yuan J, Deng Q, Dai X, Tan A, Feng Y, Zhang H, Min X, Yang X, Zhu J, Zhai K, Chang J, Qin X, Tan W, Hu Y, Lang M, Tao S, Li Y, Li Y, Feng J, Li D, Kim ST, Zhang S, Zhang H, Zheng SL, Gui L, Wang Y, Wei S, Wang F, Fang W, Liang Y, Zhai Y, Chen W, Miao X, Zhou G, Hu FB, Lin D, Mo Z, Wu T. A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk. Gut. 2014, 63(1): 143-51. (*Co-first author) (SCI Impact Factor: 14.66)

 

 

14. Deng Q, Guo H*, Dai J, Yang L, Wu C, Wang Q, Hu Z, Yang M, Liu L, Yu D, Hu D, Hong X, Qiu F, Yang H, Wang T, Tan W, Chu M, Feng J, Teng K, Gong J, Sun C, Hu X, Zhang K, Lu J, Lin D, Shen H, Wu T. Imputation-based association analyses identify new lung cancer susceptibility variants in CDK6 and SH3RF1 and their interactions with smoking in Chinese populations. Carcinogenesis. 2013, 34(9):2010-6. (*Co-first author) (SCI Impact Factor: 5.334)

 

 

15. Guo H, Deng Q, Wu C, Hu L, Wei S, Xu P, Kuang D, Liu L, Hu Z, Miao X, Dr. Shen H, Lin D, Wu T. Variations in HSPA1B at 6p21.3 are associated with lung cancer risk and prognosis in Chinese populations. Cancer Res. 2011, 71(24):7576-86. (SCI Impact Factor: 9.329)

 

 

16. Guo H, Bai Y, Xu P, Hu Z, Liu L, Wang F, Jin G, Wang F, Deng Q, Tu Y, Feng M, Lu D, Shen H, Wu T. Functional promoter -1271G>C variant of HSPB1 predicts lung cancer risk and survival. J Clin Oncol. 2010, 28(11):1928-35. (SCI Impact Factor: 18.428)

 

 

17. Yang M, Guo H*, Wu C, He Y, Yu D, Zhou L, Wang F, Xu J, Tan W, Wang G, Shen B, Yuan J, Wu T, Lin D. Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk. Hum Mutat. 2009, 30(9):1320-8. (*Co-first author) (SCI Impact Factor: 5.144)

 

 

18. He M, Guo H*, Yang X, Zhou L, Zhang X, Cheng L, Zeng H, Hu FB, Tanguay RM, Wu T. Functional SNPs in HSPA1A gene predict risk of coronary heart disease. PLoS One. 2009, 4(3):e4851. (*Co-first author) (SCI Impact Factor: 3.234)

 

合作论文

19. Li L, Chen J, Chen X, Tang J, Guo H, Wang X, Qian J, Luo G, He F, Lu X, Ding Y, Yang Y, Huang W, Hou G, Lin X, Ouyang Q, Li H, Wang R, Jiang F, Pu R, Lu J, Jin M, Tan Y, Gonzalez FJ, Cao G, Wu M, Wen H, Wu T, Jin L, Chen L, Wang H. Serum miRNAs as predictive and preventive biomarker for pre-clinical hepatocellular carcinoma. Cancer Lett. 2016 Apr 10;373(2):234-40.

 

 

20. Yang B, Deng Q, Zhang W, Feng Y, Dai X, Feng W, He X, Huang S, Zhang X, Li X, Lin D, He M, Guo H, Sun H, Yuan J, Lu J, Hu FB, Zhang X, Wu T. Exposure to Polycyclic Aromatic Hydrocarbons, Plasma Cytokines, and Heart Rate Variability. Sci Rep. 2016 Jan 13;6:19272.

 

 

21. Zhu X, Li J, Deng S, Yu K, Liu X, Deng Q, Sun H, Zhang X, He M, Guo H, Chen W, Yuan J, Zhang B, Kuang D, He X, Bai Y, Han X, Liu B, Li X, Yang L, Jiang H, Zhang Y, Hu J, Cheng L, Luo X, Mei W, Zhou Z, Sun S, Zhang L, Liu C, Guo Y, Zhang Z, Hu FB, Liang L, Wu T. Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in Chinese. Environ Health Perspect. 2016 Jan 12. [Epub ahead of print]

 

 

22. Wang Z, Seow WJ, Shiraishi K, Hsiung CA, Matsuo K, Liu J, Chen K, Yamji T, Yang Y, Chang IS, Wu C, Hong YC, Burdett L, Wyatt K, Chung CC, Li SA, Yeager M, Hutchinson A, Hu W, Caporaso N, Landi MT, Chatterjee N, Song M, Fraumeni JF Jr, Kohno T, Yokota J, Kunitoh H, Ashikawa K, Momozawa Y, Daigo Y, Mitsudomi T, Yatabe Y, Hida T, Hu Z, Dai J, Ma H, Jin G, Song B, Wang Z, Cheng S, Yin Z, Li X, Ren Y, Guan P, Chang J, Tan W, Chen CJ, Chang GC, Tsai YH, Su WC, Chen KY, Huang MS, Chen YM, Zheng H, Li H, Cui P, Guo H, Xu P, Liu L, Iwasaki M, Shimazu T, Tsugane S, Zhu J, Jiang G, Fei K, Park JY, Kim YH, Sung JS, Park KH, Kim YT, Jung YJ, Kang CH, Park IK, Kim HN, Jeon HS, Choi JE, Choi YY, Kim JH, Oh IJ, Kim YC, Sung SW, Kim JS, Yoon HI, Kweon SS, Shin MH, Seow A, Chen Y, Lim WY, Liu J, Wong MP, Lee VH, Bassig BA, Tucker M, Berndt SI, Chow WH, Ji BT, Wang J, Xu J, Sihoe AD, Ho JC, Chan JK, Wang JC, Lu D, Zhao X, Zhao Z, Wu J, Chen H, Jin L, Wei F, Wu G, An SJ, Zhang XC, Su J, Wu YL, Gao YT, Xiang YB, He X, Li J, Zheng W, Shu XO, Cai Q, Klein R, Pao W, Lawrence C, Hosgood HD 3rd, Hsiao CF, Chien LH, Chen YH, Chen CH, Wang WC, Chen CY, Wang CL, Yu CJ, Chen HL, Su YC, Tsai FY, Chen YS, Li YJ, Yang TY, Lin CC, Yang PC, Wu T, Lin D, Zhou B, Yu J, Shen H, Kubo M, Chanock SJ, Rothman N, Lan Q. Hum Mol Genet. 2016 Jan 4. pii: ddv494. [Epub ahead of print]

 

 

23. Liu B, Feng W, Wang J, Li Y, Han X, Hu H, Guo H, Zhang X, He M. Association of urinary metals levels with type 2 diabetes risk in coke oven workers. Environ Pollut. 2015 Dec 12;210:1-8.

 

 

24. Feng W, Huang X, Zhang C, Liu C, Cui X, Zhou Y, Sun H, Qiu G, Guo H, He M, Zhang X, Yuan J, Chen W, Wu T. The dose-response association of urinary metals with altered pulmonary function and risks of restrictive and obstructive lung diseases: a population-based study in China. BMJ Open. 2015 May 21;5(5):e007643.

 

 

25. Feng W, Cui X, Liu B, Liu C, Xiao Y, Lu W, Guo H, He M, Zhang X, Yuan J, Chen W, Wu T. Association of urinary metal profiles with altered glucose levels and diabetes risk: a population-based study in China. PLoS One. 2015 Apr 13;10(4):e0123742.

 

 

26. Deng Q, Dai X, Guo H, Huang S, Kuang D, Feng J, Wang T, Zhang W, Huang K, Hu D, Deng H, Zhang X, Wu T. Polycyclic Aromatic Hydrocarbons-Associated MicroRNAs and Their Interactions with the Environment: Influences on Oxidative DNA Damage and Lipid Peroxidation in Coke Oven Workers. Environ Sci Technol. 2014, 48(7):4120-8. (SCI Impact Factor: 5.481)

 

 

27. Yang B, Mo Z, Wu C, Yang H, Yang X, He Y, Gui L, Zhou L, Guo H, Zhang X, Yuan J, Dai X, Li J, Qiu G, Huang S, Deng Q, Feng Y, Guan L, Hu D, Zhang X, Wang T, Zhu J, Min X, Lang M, Li D, Hu FB, Lin D, Wu T, He M. A genome-wide association study identifies common variants influencing serum uric acid concentrations in a Chinese population. BMC Med Genomics. 2014, 7(1):10. (SCI Impact Factor: 3.914)

 

 

28. Zhou L, He M, Mo Z, Wu C, Yang H, Yu D, Yang X, Zhang X, Wang Y, Sun J, Gao Y, Tan A, He Y, Zhang H, Qin X, Zhu J, Li H, Lin X, Zhu J, Min X, Lang M, Li D, Zhai K, Chang J, Tan W, Yuan J, Chen W, Wang Y, Wei S, Miao X, Wang F, Fang W, Liang Y, Deng Q, Dai X, Lin D, Huang S, Guo H, Lilly Zheng S, Xu J, Lin D, Hu FB, Wu T. A genome wide association study identifies common variants associated with lipid levels in the Chinese population. PLoS One. 2013, 8(12):e82420. (SCI Impact Factor: 3.534)

 

 

29. Li J, Gui L, Wu C, He Y, Zhou L, Guo H, Yuan J, Yang B, Dai X, Deng Q, Huang S, Guan L, Hu D, Deng S, Wang T, Zhu J, Min X, Lang M, Li D, Yang H, Hu FB, Lin D, Wu T, He M. Genome-wide association study on serum alkaline phosphatase levels in a Chinese population. BMC Genomics. 2013, 14:684. (SCI Impact Factor: 4.041)

 

 

30. Qiu G, Feng Y, Li X, Deng H, Dai X, Deng Q, Huang S, He M, Guo H, Zhang X, Hu FB, Wu T. Disturbed heart rate variability: a dose-dependent response to elevated nitric oxide and carbon monoxide in exhaled breath. Int J Cardiol. 2013, 168(6):e155-7. (SCI Impact Factor: 6.175)

 

 

31. Dai X, Yuan J, Yao P, Yang B, Gui L, Zhang X, Guo H, Wang Y, Chen W, Wei S, Miao X, Li X, Min X, Yang H, Fang W, Liang Y, Hu FB, Wu T, He M. Association between serum uric acid and the metabolic syndrome among a middle- and old-age Chinese population. Eur J Epidemiol. 2013, 28(8):669-76. (SCI Impact Factor: 5.147)

 

 

32. Shi Y, Lian Y, Zhou L, Huang L, Zhang X, Guo H, Wu T, Cheng L, He M. Association between genetic variations in TFR2 gene and coronary heart disease in Chinese: a case-control study. J Cardiovasc Med (Hagerstown). 2013 Jun 7. [Epub ahead of print] (SCI Impact Factor: 1.407)

 

 

33. Dai X, Wu C, He Y, Gui L, Zhou L, Guo H, Yuan J, Yang B, Li J, Deng Q, Huang S, Guan L, Hu D, Zhu J, Min X, Lang M, Li D, Yang H, Hu FB, Lin D, Wu T, He M. A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population. Genet Epidemiol. 2013, 37(3):293-300. (SCI Impact Factor: 2.951)

 

 

34. Dong J, Jin G, Wu C, Guo H, Zhou B, Lv J, Lu D, Shi Y, Shu Y, Xu L, Chu M, Wang C, Zhang R, Dai J, Jiang Y, Yu D, Ma H, Zhao X, Yin Z, Yang L, Li Z, Deng Q, Cao S, Qin Z, Gong J, Sun C, Wang J, Wu W, Zhou G, Chen H, Guan P, Chen Y, Liu X, Liu L, Xu P, Han B, Bai C, Zhao Y, Zhang H, Yan Y, Liu J, Amos CI, Chen F, Tan W, Jin L, Wu T, Hu Z, Lin D, Shen H. Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in han chinese. PLoS Genet. 2013;9(1):e1003190. (SCI Impact Factor: 8.167)

 

 

35. Tang L, Wang H, Lu X, Jian X, Jin B, Zheng H, Li Y, Wang Q, Wu T, Guo H, Liu H, Guo T, Yu J, Yang R, Yang Y, Hu Y. Common genetic risk factors for venous thrombosis in the Chinese population. Am J Hum Genet. 2013, 92(2):177-87. (SCI Impact Factor: 10.987)

 

 

36. Wang F, Zhu J, Yao P, Li X, He M, Liu Y, Yuan J, Chen W, Zhou L, Min X, Fang W, Liang Y, Wang Y, Wei S, Liu J, Miao X, Lang M, Jiang X, Zhang P, Li D, Lu C, Wang X, Shi W, Zheng J, Guo H, Zhang X, Yang H, Hu FB, Wu T. Cohort profile: The Dongfeng-Tongji cohort study of retired workers. Int J Epidemiol. 2013, 42(3):731-740. (SCI Impact Factor: 9.197)

 

 

37. Chen M, He M, Min X, Pan A, Zhang X, Yao P, Li X, Liu Y, Yuan J, Chen W, Zhou L, Fang W, Liang Y, Wang Y, Miao X, Lang M, Zhang P, Li D, Guo H, Yang H, Hu FB, Wu T. Different physical activity subtypes and risk of metabolic syndrome in middle-aged and older Chinese people. PLoS One. 2013;8(1):e53258. (SCI Impact Factor: 3.534)

 

 

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