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鲁文清

  • 中文简历English resume
  • 姓名:鲁文清
  • 职务:教授、博士生导师
  • 院系:劳动卫生与环境卫生学系
  • 地址:湖北省武汉市航空路13号 430030
  • 电话:
  • 邮箱:luwq@mails.tjmu.edu.cn

 

1976年毕业于同济医科大学卫生专业,毕业后留校工作,历任公共卫生学院助教、讲师、副教授,2000年任教授,2002年任博士生导师。1994年获德国海德堡大学医学博士学位,1992年至2002年期间分别以高级访问学者和高级研究员赴德国海德堡大学、德国特里尔大学和德国吉森大学开展科研合作工作。兼任中华预防医学会环境卫生专业委员会副主任委员、中国环境科学学会环境医学与健康分会常务委员、《中华预防医学杂志》、《环境与职业医学》和《中国职业医学》杂志编委、国际杂志《The Open Environmental Journal》编委,人民卫生出版社大型参考书《现代环境卫生学》副主编、“十一五” 国家级规划教材《环境卫生学》(供7年制和研究生用)编委兼学术秘书、普通高等教育“十一五”国家级规划教材《环境卫生学》编委。1998年在德国海德堡大学获国际人类毒理学协会授予的约翰博士奖;1999年享受国务院政府特殊津贴;2007年《水污染与健康研究》获中华预防医学会科学技术奖二等奖和教育部高等学校科技进步奖二等奖(第2名);2009年《DNA氧化性损伤分子生物学标志物研究及其在预防医学中的应用》获中华预防医学会科学技术奖三等奖(第3名);2011年《典型持久性有机污染物的健康危害及其毒作用机制研究》获年教育部高等学校自然科学奖二等奖(第2名)。

 

主要研究领域

主要有:(1)饮用水污染与健康;(2)POPs联合作用的毒理学机制;(3)环境遗传毒理学;(4)化学物联合致突变、抗突变和联合致癌、抗癌的综合作用研究。近年主要从事典型环境污染物对健康影响的相关研究,对重要的有机污染物多环芳烃、多氯联苯、氯化消毒副产物、邻苯二甲酸酯的遗传毒性风险和生殖健康危害风险进行了一系列研究。先后主持国家自然科学基金面上项目4项、是国家“十一五”科技支撑计划《饮水安全评价、预警技术研究》的课题负责人之一、分别是国家973项目《环境化学污染物致机体损伤及其防御的基础研究》和国家自然科学基金重大项目《低纬度地区典型POPs与机体相互作用的机制研究》项目组主要成员。

 

 

主要著作或论文

1. Wang YX, Feng W, Sun Y, Zeng Q, Wang P, Yang P, Huang YH, Lu WQ*, Variability of metal levels in spot, first morning and 24-h urine samples over a 3-month period in healthy adult Chinese men, Environ Health Persp 2016, 124(4):468-476.

 

2. Cao WC, Zeng Q, Luo Y, Chen HX, Miao DY, Li L, Cheng YH, Li M, Wang F, You L, Wang YX, Yang P, Lu WQ*, Blood biomarkers of late pregnancy exposure to trihalomethanes in drinking water and fetal growth measures and gestational age in a Chinese cohort, Environ Health Persp 2016, 124(4):536-541

 

3. Wang, YX, Sun Y, Feng W, Wang P, Wang C, Yang P, Li J, Huang Z, Yue J, Gu LJ, Zeng Q, Lu WQ*, Association of urinary metal levels with human semen quality: A cross-sectional study in China, Environ Int 2016, 91:51-59

 

4. Zeng Q, Zhou B, He DL, Wang YX, Wang M, Yang P, Huang Z, Li J, Lu WQ*, Joint effects of trihalomethanes and trichloroacetic acid on semen quality: A population-based cross-sectional study in China, Environ Pollut 2016, 212:544-549

 

5. Wang YX, Sun Y, Yang P, Wang P, You L, Huang YH, Li J, Huang Z, Wang C, Li YF, Zeng Q, Lu WQ*, Semen phthalate metabolites, semen quality parameters and serum reproductive hormones: A cross-sectional study in China. Environ Pollut 2016, 211:173-182

 

6. Yang P, Zeng Q, Cao WC, Wang YX, Huang Z, Li J, Liu C, Lu WQ*,Interactions between CYP2E1, GSTZ1 and GSTT1 polymorphisms and exposure to drinking water trihalomethanes and their association with semen quality, Environ Res 2016, 147:445-452

 

7. Wang YX, Zeng Q, Sun Y, You L, Wang P, Li Min, Yang P, Huang Z, Wang C, Li S, Dan Y, Li YF, Lu WQ*, Phthalate exposure in association with serum hormone levels, sperm DNA damage and spermatozoa apoptosis: A cross-sectional study in China, Environ Res 2015, DOI: 10.1016/j.envres.2015.11.023

 

8. Wang YX, You L, Zeng Q, Sun Y, Huang YH, Wang C, Gu LJ, Cao WC, Yang P, Li YF, Lu WQ*, Phthalate exposure and human semen quality: Results from an infertility clinic in China, Environ Res 2015, 142:1-9

 

9. Zeng Q, Zhang SH, Liao J, Miao DY, Yang P, Wang YX, You L, Yun LJ, Liu AL, Lu WQ*, Evaluation of genotoxic effects caused by extracts of chlorinated drinking water using a combination of three different bioassays, J Hazard Mater 2015, 296:23-29

 

10. Zeng Q, Feng W, Zhou B, Wang YX, He XS, Yang P, You L, Yue J, Li YF, Lu WQ*, Urinary metal concentrations in relation to semen quality: A cross- sectional study in China, Environ Sci Technol 2015, 49(8):5052-5059

 

11. You L, Wang YX, Zeng Q, Li M, Huang YH, Hu Y, Cao WC, Liu AL, Lu WQ*, Semen phthalate metabolites, spermatozoa apoptosis and DNA damage: A cross-sectional study in China, Environ Sci Technol 2015, 49(6):3805-3812

 

 

12. Wang YX, Zeng Q, Wang L, Huang YH, Lu ZW, Wang P, He MJ, Huang R, Lu WQ*, Temporal variability in urinary levels of drinking water disinfection byproducts dichloroacetic acid and trichloroacetic acid among men. Environ Res 2014, 135:126-132

 

13. Zeng Q, Zhou B, Cao WC, Wang YX, You L, Huang YH, Yang P, Liu AL, Lu WQ*, Predictors of urinary trichloroacetic acid and baseline blood trihalomethanes concentrations among men in China, Sci Total Environ 2014, 493C:806-811

 

14. Zeng Q, Chen YZ, Xu L, Chen HX, Luo Y, Li M, Yue J, Liu AL, Li YF, Lu WQ*, Evaluation of exposure to trihalomethanes in tap water and semen quality: A prospective study in Wuhan, China. Reprod Toxicol 2014, 46C:56-63

 

15. Zeng Q, Wang YX, Xie SH, Xu L, Chen YZ, Li M, Yue J, Li YF, Liu AL, Lu WQ*, Drinking-water disinfection by-products and semen quality: a cross-sectional study in China. Environ Health Persp 2014, 122(7):741-746

 

16. Liao J, Li XF, Zhou SC, Luo Y, Liu AL, Lu WQ*, Bromodichloromethane induces cell proliferation in different tissues of male F344 rats by suppression of E-cadherin expression via hypermethylation or transcriptional activation of c-myc and cyclin D1. Toxic Lett 2013, 223(2):162-174

 

17. Zeng Q, Zhou B, Feng W, Wang YX, Liu AL, Yue J, Li YF, Lu WQ*, Associations of urinary metal concentrations and circulating testosterone in Chinese men. Reprod Toxicol 2013, 14:109-114

 

18. Zeng Q, Cao WC, Xu L, Chen YZ, Yun LJ, Liu AL, Zhang J, Lu WQ*, Spatial and temporal evaluations of estrogenic activity in tap water served by a water plant in Wuhan, China. Ecotox Environ Safe 2013, 91:198-203

 

19. Zeng Q, Li M, Xie SH, Gu LJ, Yue J, Cao WC, Zheng D, Liu AL, Li YF, Lu WQ*, Baseline blood trihalomethanes, semen parameters and serum total testosterone: a cross-sectional study in China. Environ Int 2013, 54:134-140

 

20. Zhou WS, Xu L, Xie SH, Li YL, Li L, Zeng Q, Du YK, Lu WQ*, Decreased birth weight in relation to maternal urinary trichloroacetic acid levels. Sci Total Environ 2012, 416:105-110

 

21. Zhang L, Xu L, Zeng Q, Zhang SH, Xie H, Liu AL, Lu WQ*, Comparison of DNA damage in human-derived hepatoma line (HepG2) exposed to the fifteen drinking water disinfection byproducts using the single cell gel electrophoresis assay. Mutat Res 2012, 741(1-2):89-94

 

22. Xie SH, Li YF, Tan YF, Zheng D, Liu AL, Xie H, Lu WQ*, Urinary trichloroacetic acid levels and semen quality: a hospital-based cross-sectional study in Wuhan, China. Environ Res 2011, 111:295-300

 

23. Zhang SH, Miao DY, Liu AL, Zhang L, Wei W, Xie H, Lu WQ*. Assessment of the cytotoxicity and genotoxicity of haloacetic acids using microplate-based. cytotoxicity test and CHO/HGPRT gene mutation assay. Mutat Res 2010, 703:174-179

 

24. Xie SH, Liu AL, Chen YY, Zhang L, Zhang HJ, Jin BX, Lu WH, Li XY, Lu WQ*, DNA damage and oxidative stress in human liver cell L-02 caused by surface water extracts during drinking water treatment in a waterworks in China. Environ Mol Mutagen 2010, 51:229-235

 

25. Wei W, Zhang C, Liu AL, Xie SH, Chen XM, Lu WQ*, PCB126 enhanced the genotoxicity of BaP in HepG2 cells by modulating metabolic enzyme and DNA repair activities. Toxicol Lett 2009, 189(2):91-95

 

26. Wei W, Zhang C, Liu AL, Xie SH, Chen XM, Lu WQ*, Effect of PCB153 on BaP-induced genotoxicity in HepG2 cells via modulation of metabolic enzymes. Mutat Res 2009, 675 (1-2):71-76

 

27. Yuan J, Liu H, Zhou LH, Zou YL, Lu WQ*. Oxidative stress and DNA damage induced by a drinking-water chlorination disinfection byproduct 3-chloro-4-(dichloromethyl)-5- hydroxy-2(5H)-furanone (MX) in mice. Mutat Res 2006, 609(2):129-136

 

28. Liu AL, Lu WQ*, Wang ZZ, Chen WH, Lu WH, Yuan J, Nan PH, Sun JY, Zou JL, Zhou LH, Zhang C and Wu TC, Elevated levels of urinary 8-hydroxy-22- deoxyguanosine, lymphocytes micronucleus and serum glutathione S-transferase in workers exposed to coke oven emissions. Envrion Health Persp 2006, 114(51):673-677

 

29. Yuan J, Wu XJ, Lu WQ*, Cheng XL, Chen D, Li XY, Liu AL, Wu JJ, Xie H, Stahl T, Mersch-Sundermann V. Chlorinated river and lake water extract caused oxidative damage, DNA migration and cytotoxicity in human cells. Int J Hyg Environ Health 2005, 208(6): 481-488
30. 鲁文清(主编),水污染与健康,湖北科学技术出版社,2015,武汉