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严红

  • 中文简历English resume
  • 姓名:严红
  • 职务:副教授,博士生导师
  • 院系:卫生毒理学系
  • 地址:湖北省武汉市航空路13号 430030
  • 电话:
  • 邮箱:yanhong@mails.tjmu.edu.cn

教育和工作经历

2000,12-至今:华中科技大学同济医学院卫生毒理学系,副教授

1998,7-2000,12:华中科技大学同济医学院卫生毒理学系,讲师

2007,11-2008,12:美国宾夕法尼亚大学访问学者

1987~1992: 同济医科大学环境医学专业,学士学位

1992~1995: 同济医科大学卫生毒理专业,硕士学位士

1995~1998: 同济医科大学劳动卫生与环境卫生专业,博士学位

主要社会兼职

湖北省毒理学会常务理事

中国毒理学会生化与分子毒理学专业委员会委员

中国毒理学会遗传毒理学专业委员会委员

中国毒理学会神经毒理学专业委员会委员

主要研究领域

环境污染物与神经系统疾病及机制

主要科研项目

1 Nrf2 和NF-κB 的crosstalk 介导丙烯酰胺对多巴胺能神经元的损伤及机制的研究,国家自然科学基金(8137304),2014,1-2017,12

2丙烯酰胺致大脑纹状体神经元凋亡及N-乙酰半胱氨酸拮抗的分子机制,武汉市科技计划项目(2013062301010805) 2014,1~2015,12

3 DAT在丙烯酰胺神经毒性中的作用,湖北省自然科学基金(2011CDB361)2012,1-2013,12

4 SNO介导丙烯酰胺对黑质纹状体多巴胺系统影响的研究,教育部留学回国人员科研启动基金(第43批)2012,1-2013,12

5 褪黑素对丙烯酰胺神经系统氧化损伤的保护作用及Nrf2/HO-1 介导的机制研究,国家自然科学基金(30771822,),2007,1-2008,12

代表性论文

1 Xiaoqi Pan, Dandan Yan, Dun Wang , Xu Wu, Wanyun Zhao, Qing Lu,Hong Yan*, Mitochondrion-Mediated Apoptosis Induced by Acrylamideis Regulated by a Balance Between Nrf2 Antioxidant and MAPK Signaling Pathways in PC12 Cells, Mol Neurobiol,2017;54:4781-4794, DOI 10.1007/s12035-016-0021-1

2  Dandan Yan ,Yunjian Zhang, Liegang Liu , Hong Yan* , Pesticide exposure and risk of Alzheimer’s disease: a systematic review and meta-analysis Scientific Reports ,2016,Sep 1;  6:32222 | DOI: 10.1038/srep32222

3 Xiaoqi Pan, XiongxiongGuo, FeiXiong, Guihong Cheng, Qing Lu,* Hong Yan,* Acrylamide increases dopamine levels by affecting dopamine transport and metabolism related genes in the striatal dopaminergic system,Toxicology Letters, 2015,236:60-68

4 Xiaoqi Pan, Lanlan Zhu, Huiping Lu, Dun Wang, Qing Lu, Hong Yan,*Melatonin Attenuates Oxidative Damage Induced by Acrylamide In Vitro and In Vivo, Oxidative Medicine and Cellular Longevity,2015;2015:703709.doi:10.1155/2015/703709

5 Wei Yang, Juan Fu, Miao Yu, Di Wang, Ying Rong, Ping Yao, Andreas K. Nüssler, Hong Yan *,Liegang Liu*,Effects of Three Kinds of Curcuminoidson Anti-Oxidative System and MembraneDeformation of Human Peripheral Blood Erythrocytes in High Glucose Levels, Cell  Physiol  Biochem 2015;35:789-802

6 Hui Gao, Di Wang , Shun Zhang , Mengjing Xu , Wei Yang , Peipei Yan ,Yang Liu , Xiao Luo , Hailei Wu, Ping Yao , Hong Yan ** , Liegang Liu **,Roles of ROS mediated oxidative stress and DNA damage in 3-methyl-2-quinoxalin benzenevinylketo-1, 4-dioxide-induced immunotoxicityof SpragueeDawley rats, Regulatory Toxicology and Pharmacology, 2015, 73: 587-594

7  Wei Yang, Miao Yu, Juan Fu, Wei Bao , Di Wang, Liping Hao , Ping Yao,Andreas K. Nüssler , Hong Yan* , Liegang Liu* Deoxynivalenol induced oxidative stress and genotoxicity in human peripheral blood lymphocytes, Food and Chemical Toxicology 2014,64: 383–396

8  Miao Yu, Di Wang , Mengjing Xu, Yang Liu , Xia Wang , Jun Liu , Xuefeng Yang , Ping Yao, Hong Yan*, Liegang Liu*, Quinocetone-induced Nrf2/HO-1 pathway suppression aggravates hepatocyte damage of Sprague–Dawley rats, Food and Chemical Toxicology 2014,69:210–219

9 Di Wang, Xiao Luo , Ying Zhong, Wei Yang , Mengjing Xu , Yang Liu , Jie Meng , Ping Yao, Hong Yan * , Liegang Liu *, Pu-erh black tea extract supplementation attenuates the oxidative DNA damage and oxidative stress in Sprague–Dawley rats with renal dysfunction induced by subchronic 3-methyl-2-quinoxalin benzenevinylketo-1,4-dioxide exposure, Food and Chemical Toxicology 2012,50: 147–154