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王爱国

  • 中文简历English resume
  • 姓名:王爱国
  • 职务:教授,博士生导师,教育部新世纪优秀人才,劳动卫生与环境卫生学系副主任
  • 院系:劳动卫生与环境卫生学系
  • 地址:湖北省武汉市航空路13号 430030
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王爱国,1982.09―1987.07 湖南医科大学卫生系,本科学历/学士学位。1989.09―1992.07 华中科技大学同济医学院公共卫生学院环境卫生学教研室硕士研究生,获医学硕士学位,导师陈学敏教授。1997.08―1999.10 德国Ulm大学博士研究生,获医学博士学位,导师Andreas Nüssler。自1987年7月参加工作以来一直从事环境卫生学和环境毒理学的教学和科研工作。主要研究领域为外源性化合物的毒性作用及其分子机制研究。主要社会兼职为中华医学会地方病学分会委员等。主持的“典型持久性有机污染物的健康危害及其毒作用机制研究”获2011年度教育部高等学校科学研究优秀成果奖自然科学二等奖。

 

主要著作或论文

[1]Chunyang Jiang, Shun Zhang, HongLiang Liu, Qiang Zeng, Tao Xia, Yihu Chen, Gang Kuang, Guodong Zhao, Xue Wu, Xiaofei Zhang, Aiguo Wang*. The role of the IRE1 pathway in PBDE-47-induced toxicity in human neuroblastoma SH-SY5Y cells in vitro. Toxicol Lett. 2012, 211(3):325-33.1.

 

[2]Qiang Niu, HongLiang Liu, ZhiZhong Guan, Qiang Zeng, ShuXia Guo, Ping He, LiJuan Guo, Ping Gao, BaYi Xu, ZhiXia Xu, Tao Xia, Aiguo Wang*. The Effect of c-Fos Demethylation on Sodium Fluoride-induced Apoptosis in L-02 Cells. Biol Trace Elem Res. 2012, 149(1):102-9.

 

[3]Ping He, Aiguo Wang*, Qiang Niu, Lijuan Guo, Tao Xia, Xuemin Chen. Toxic effect of PBDE-47 on thyroid development, learning, and memory, and the interaction between PBDE-47 and PCB153 that enhances toxicity in rats. Toxicol Ind Health, 2011, 27(3):279-88.

 

[4]Bayi Xu, Zhixia Xu, Tao Xia, Ping He, Ping Gao, Weihong He, Ming Zhang, Lijuan Guo, Qiang Niu, Aiguo Wang*. Effects of the Fas/Fas-L pathway on fluoride-induced apoptosis in SH-SY5Y cells. Environ Toxicol. 2011, 26(1):86-92.

 

[5]Weihong He, Aiguo Wang*, Tao Xia, Ping Gao, Bayi Xu, Zhixia Xu, Ping He, Xuemin Chen. Cytogenotoxicity induced by PBDE-47 combined with PCB153 treatment in SH-SY5Y cells. Environ Toxicol. 2010, 25(6):564-572.

 

[6]Ping Gao, Ping He, Aiguo Wang*, Tao Xia, BaYi Xu, ZhiXia Xu, Qiang Niu, LiJuan Guo, XueMin Chen. Influence of PCB153 on oxidative DNA damage and DNA repair-related gene expression induced by PBDE-47 in human neuroblastoma cells in vitro. Toxicol Sci. 2009, 107(1):165-70.

 

[7]Ping He, Aiguo Wang*, Tao Xia, Ping Gao, Qiang Niu, Lijuan Guo, Xuemin Chen. Mechanisms of the neurotoxic effect of PBDE-47 and interaction of PBDE-47 and PCB153 in enhancing toxicity in SH-SY5Y cells. Neurotoxicology. 2009, 30(1):10-5.

 

[8]Ping He, Aiguo Wang*, Tao Xia, Ping Gao, Qiang Niu, Lijuan Guo, Xuemin Chen. Mechanisms underlying the developmental neurotoxic effect of PBDE-47 and the enhanced toxicity associated with its combination with PCB153 in rats. Neurotoxicology. 2009, 30(6):1088-95.

 

[9]Weihong He, Ping He, Aiguo Wang*, Tao Xia, Bayi Xu, Xuemin Chen. Effects of PBDE-47 on cytotoxicity and genotoxicity in human neuroblastoma cells in vitro. Mutat Res. 2008, 649(1-2):62-70.

 

[10]Ping He, Weihong He, Aiguo Wang*, Tao Xia, Bayi Xu, Ming Zhang, Xuemin Chen. PBDE-47-induced oxidative stress, DNA damage and apoptosis in primary cultured rat hippocampal neurons. Neurotoxicology. 2008, 29(1):124-9.

 

[11]Ming Zhang, Aiguo Wang*, Tao Xia, Ping He. Effects of fluoride on DNA damage, S-phase cell-cycle arrest and the expression of NF-kappaB in primary cultured rat hippocampal neurons. Toxicol Lett. 2008; 179(1):1-5.

 

[12]Ming Zhang, Aiguo Wang*, Weihong He, Ping He, Bayi Xu, Tao Xia, Xuemin Chen, Kedi Yang. Effects of fluoride on the expression of NCAM, oxidative stress, and apoptosis in primary cultured hippocampal neurons. Toxicology. 2007, 236(3):208-16.

 

[13]Xianzhi Xiong, Junling Liu, Weihong He, Tao Xia, Ping He, Xuemin Chen, Kedi Yang, Aiguo Wang*. Dose-effect relationship between drinking water fluoride levels and damage to liver and kidney functions in children. Environ Res. 2007, 103(1):112-6.

 

[14]Xianzhi Xiong, Aiguo Wang*, Guohong Liu, Hongkai Liu, Chong Wang, Tao Xia, Xuemin Chen, Kedi Yang. Effects of p,p’-dichlorodiphenyldichoroethylene on the expressions of transferrin and androgen-binding protein in rat Sertoli cells. Environ Res. 2006, 101(3):334-9.

 

[15]Junling Liu, Tao Xia, Ming Zhang, Weihong He, Ping He, Xuemin Chen, Kedi Yang, Aiguo Wang*. Screening of environmental response genes related to dental fluorosis. Fluoride. 2006, 39(3):195-201

 

[16]Aiguo Wang*, Qilong Chu, Weihong He, Tao. Xia, Junling Liu, Ming Zhang, Andreas Nussler, Xuemin Chen, Kide Yang. Effects on protein and mRNA expression levels of p53 induced by fluoride in human embryonic hepatocytes. Toxicol Lett. 2005, 158(2):158-63.

 

[17]Aiguo Wang*, Tao Xia, Qilong Chu, Ming Zhang, Fang Liu, Xuemin Chen, and Kedi Yang. Effects of fluoride on peroxidation, DNA damage and apoptosis in human embryo hepatocytes. Biomedicine and Environmental Science. 2004, 17:217-222.

 

[18]Aiguo Wang*, Tao Xia, Jing Yuan, Rian Yu, Kedi Yang, Xuemin Chen, Wei Qu, M.P.Waalkes. Effects of phenobarbital on metabolism and toxicity of diclofenac sodium in rat hepatocytes in vitro. Food and Chem Toxicol, 2004, 42(10):1647-53.

 

[19]Aiguo Wang*, Tao Xia, Rian Ru, Xuemin Chen, KediYang. Antagonistic effects of selenium on oxidative stress, DNA damage, and apoptosis induced by fluoride in human hepatocytes. Fluoride. 2004, 37(2):107-16.