1994年毕业于同济医科大学，在武钢工业卫生研究所从事职业卫生工作至副主任医师。2008年获华中科技大学劳动卫生与环境卫生学医学博士学位，同年以人才留校。2011-2012年在美国哈佛大学公共卫生学院做访问学者。主要从事《预防医学》、《职业卫生与职业医学》以及《职业危害与健康》等课程的教学工作。主持并参与了国家自然科学基金面上项目和重点项目、“973” 计划、“十一五” 科技支撑计划、卫生行业科研专项、CMB中美合作项目与教育部创新团队等项目。已发表SCI论文60多篇，包括Circulation，Diabetes，AJCN, Hypertension，Arterioscler Thromb Vasc Biol，Clin Chem等国际权威或著名期刊，为中国抗癌协会肿瘤病因学专业委员会青年委员、湖北省预防医学会劳动卫生与职业病专业委员会委员、武汉预防医学会理事。曾获“全国优秀百篇博士论文提名奖”，教育部新世纪优秀人才计划支持，国家自然科学奖二等奖等。

主要研究领域

环境相关疾病的分子流行病学研究，主要致力于基因/蛋白-环境交互作用在心血管危险因素、早期心血管损害与环境相关疾病（冠心病、代谢性疾病和职业相关疾病）的研究。

主要代表性论文（*通讯作者）

1. Yang L, Yang H, He M, Pan A, Li X, Min X, Zhang C, Xu C, Zhu X, Yuan J, Wei S, Miao X, Hu FB, Wu T, Zhang X*. Longer sleep duration and midday napping are associated with a higher risk of chd incidence in middle-aged and older chinese: The dongfeng-tongji cohort study. Sleep. 2016;39:645-652

2. Feng Y, Huang X, Sun H, Liu C, Zhang B, Zhang Z, Sharma Tengur V, Chen W, Wu T, Yuan J, Zhang X*. Framingham risk score modifies the effect of PM10 on heart rate variability. Sci Total Environ. 2015;523:146-151

3. Yang L, Zhou Y, Sun H, Lai H, Liu C, Yan K, Yuan J, Wu T, Chen W, Zhang X*. Dose-response relationship between polycyclic aromatic hydrocarbon metabolites and risk of diabetes in the general chinese population. Environmental pollution. 2014;195C:24-30

4. Feng Y, Sun H, Song Y, Bao J, Huang X, Ye J, Yuan J, Chen W, Christiani DC, Wu T, Zhang X*. A community study of the effect of polycyclic aromatic hydrocarbon metabolites on heart rate variability based on the framingham risk score. Occup Environ Med. 2014

5. Ye J, Zhu R, He X, Feng Y, Yang L, Zhu X, Deng Q, Wu T, Zhang X*. Association of plasma IL-6 and Hsp70 with hrv at different levels of PAHs metabolites. PLoS One. 2014;9:e92964

6. Zhang X, Hu EA, Wu H, Malik V, Sun Q. Associations of leg fat accumulation with adiposity-related biological factors and risk of metabolic syndrome. Obesity (Silver Spring). 2013;21:824-830

7. Zhang X, Qi Q, Zhang C, Hu FB, Sacks FM, Qi L. Fto genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: The pounds lost trial. Diabetes. 2012;61:3005-3011

8. Zhang X*, Qi Q, Liang J, Hu FB, Sacks FM, Qi L. Neuropeptide y promoter polymorphism modifies effects of a weight-loss diet on 2-year changes of blood pressure: The preventing overweight using novel dietary strategies trial. Hypertension. 2012;60:1169-1175

9. Zhang X*, Qi Q, Bray GA, Hu FB, Sacks FM, Qi L. Apoa5 genotype modulates 2-y changes in lipid profile in response to weight-loss diet intervention: The pounds lost trial. AM J CLIN NUTR. 2012;96:917-922

10. Zhang X*, Tanguay RM, He M, Deng Q, Miao X, Zhou L, Wu T. Variants of hspa1a in combination with plasma hsp70 and anti-hsp70 antibody levels associated with higher risk of acute coronary syndrome. Cardiology. 2011;119:57-64

11. Zhang X, Xu Z, Zhou L, Chen Y, He M, Cheng L, Hu FB, Tanguay RM, Wu T. Plasma levels of hsp70 and anti-hsp70 antibody predict risk of acute coronary syndrome. Cell Stress Chaperones. 2010;15:675-686

12. Zhou L, Zhang X, He M, Cheng L, Chen Y, Hu FB, Wu T. Associations between single nucleotide polymorphisms on chromosome 9p21 and risk of coronary heart disease in chinese han population. Arterioscler Thromb Vasc Biol. 2008;28:2085-2089（Co-first author）

13. Zhang X, He MA, Cheng L, Zhou L, Zeng H, Wang J, Wang F, Chen Y, Hu FB, Wu T. Joint effects of antibody to heat shock protein 60, hypertension, and diabetes on risk of coronary heart disease in chinese. Clin Chem. 2008;54:1046-1052

14. Zhang X, He M, Cheng L, Chen Y, Zhou L, Zeng H, Pockley AG, Hu FB, Wu T. Elevated heat shock protein 60 levels are associated with higher risk of coronary heart disease in chinese. Circulation. 2008;118:2687-2693