教育经历

1999.09-2003.06，武汉大学，资源与环境科学学院环境科学系，学士

2004.09-2010.05，纽约大学（美国），医学院环境医学系，博士

工作经历

2010.11-2018.10 华中科技大学 公共卫生学院 副教授

2018.11-至今  华中科技大学 公共卫生学院 教授

研究方向

1. 重金属致癌的作用机制及防控

2. 纳米毒理学

主要负责的科研项目

1. 国家自然科学基金面上项目“外泌体circ-SHPRH在镉致支气管上皮细胞恶性转化中的作用及机制”（No. 81973000），2020.01-2023.12，项目负责人。

2. 国家自然科学基金面上项目“SIRT6在多壁碳纳米管致肺纤维化中的作用及机制研究”（No. 81673131），2017.01-2020.12，项目负责人。

3. 国家自然科学基金青年科学基金项目“组蛋白H3K4三甲基化在砷诱导人支气管上皮细胞恶性转化中的作用”（No. 81202237），2013.01-2015.12，项目负责人。

4. 国家高技术研究发展计划（863计划）课题“智能仿生支架定向调控细胞构建血管化组织工程皮肤及其临床应用”（No. 2015AA020313），2015.01-2017.12，子课题负责人。

5. 湖北省卫生厅青年科技人才项目“镉对人支气管上皮细胞中组蛋白H3K9二甲基化的影响及途径”（No. QJX2012-01），2013.01-2014.12，项目负责人。

6. 高等学校博士学科点专项科研基金项目“JARID1在As(Ⅲ)增加H3K4me3中的作用研究”（No. 20110142120027），2012.01-2014.12，项目负责人。

7. 国家自然科学基金重点项目“线粒体动力学改变在氟神经毒性中的作用及白藜芦醇干预效果研究”（No. 81430076），2015.01-2019.12，参与。

学术兼职

1. 中华预防医学会环境卫生分会第七届委员会青年委员会委员 2014.04

2. 中国环境诱变剂学会致突变专业委员会第三届委员会委员 2018.08

3. 湖北省预防医学会环境卫生专业委员会第六届委员会常务委员兼秘书 2016.12

4. 武汉市预防医学会第五届理事会理事 2015.09

代表性论著

1. Chen P^#, Tian K, Tu W, Zhang Q, Han L, Zhou X*. Sirtuin 6 inhibits MWCNTs-induced epithelial-mesenchymal transition in human bronchial epithelial cells via inactivating TGF-β1/Smad2 signaling pathway. Toxicol Appl Pharmacol. 2019, 374:1-10.

2. Zhang Q^#, Tu W, Tian K, Han L, Wang Q, Chen P, Zhou X*. Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-β1/Smad2 and nuclear factor-κB signaling pathways in human fetal lung fibroblasts. J Cell Biochem. 2019, 120(1):93-104.

3. Tu W^#, Zhang Q, Liu Y, Han L, Wang Q, Chen P, Zhang S, Wang A, Zhou X*. Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells. Toxicol Appl Pharmacol. 2018, 347: 60–69.

4. Tu W^#, Liu Y, Xie C, Zhou X*. Arsenite downregulates H3K4 trimethylation and H3K9 dimethylation during transformation of human bronchial epithelial cells. J Appl Toxicol. 2018, 38(4):480-488.

5. Tian K^#, Chen P, Liu Z, Si S, Zhang Q, Mou Y, Han L, Wang Q, Zhou X*. Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-β1/Smad3 signaling. Oncotarget. 2017, 8(37): 61011-61024.

6. Zhang J^#, Zhou X^#, Wu W, Wang J, Xie H, Wu Z*. Regeneration of glutathione by α-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity. Environ Toxicol Pharmacol. 2017, 51:30-37. (^#共同第一作者)

7. Shi C^#, Zhou X^#, Zhang J, Wang J, Xie H, Wu Z*. α-Lipoic acid protects against the cytotoxicity and oxidative stress induced by cadmium in HepG2 cells through regeneration of glutathione by glutathione reductase via Nrf2/ARE signaling pathway. Environ Toxicol Pharmacol. 2016, 45:274-281. (^#共同第一作者)

8. Xiao C^#, Liu Y, Xie C, Tu W, Xia Y, Costa M, Zhou X*. Cadmium induces histone H3 lysine methylation by inhibiting histone demethylase activity. Toxicol Sci. 2015, 145(1):80–89.

9. Liu Y^#, Deng H, Xiao C, Xie C, Zhou X*. Cytotoxicity of calcium rectorite micro/nanoparticles before and after organic modification. Chem Res Toxicol. 2014, 27(8):1401-1410.

10. Huang R^#, Zhou X^#, Liu X^#, Zhang Q, Jin H, Shi X, Luo W*, Deng H*. Nanofibrous mats LBL assembled by HTCC/layered silicate composites with in vitro antitumor activity against SMMC-7721 cells. J Biomed Nanotechnol. 2014, 10(3):485-499. (^#共同第一作者)

11. Xin S^#, Li X^#, Ma Z, Lei Z, Zhao J, Pan S, Zhou X*, Deng H*. Cytotoxicity and antibacterial ability of scaffolds immobilized by polysaccharide/layered silicate composite. Carbohydr Polym. 2013, 92(2):1880-1886. (共同通讯作者)

12. Xin S^#, Li X^#, Zhu Y, Zhang T, Lei Z, Li W, Zhou X*，Deng H*. Nanofibrous mats coated by homocharged biopolymer-layered silicate nanoparticles and their antitumor activity. Colloid Surface B. 2013, 105:137-143. (共同通讯作者)

13. Yang G^#, Zhou X^#, Wang J, Zhang W, Zheng H, Lu W, Yuan J*. MEHP-induced oxidative DNA damage and apoptosis in HepG2 cells correlates with p53-mediated mitochondria-dependent signaling pathway. Food Chem Toxicol. 2012, 50(7):2424-2431. (^#共同第一作者)

14. Deng H^#, Lin P^#, Xin S, Huang R, Li W, Du Y, Zhou X*, Yang J*. Quaternized chitosan-layered silicate intercalated composites based nanofibrous mats and their antibacterial activity. Carbohydr Polym. 2012, 89(2):307-313. (共同通讯作者)

15. Xu R^#, Xin S^#, Zhou X^#, Li W, Cao F, Feng X*, Deng H*. Quaternized chitosan–organic rectorite intercalated composites based nanoparticles for protein controlled release. Int J Pharm, 2012, 438(1-2): 258-265. (^#共同第一作者)

16. Jiang Y^#, Zhou X^#, Chen X^#, Yang G, Wang Q, Rao K, Xiong W, Yuan J*. Benzo(a)pyrene-induced mitochondrial dysfunction and cell death in p53-null Hep3B cells. Mutat Res. 2011, 726(1):75-83. (^#共同第一作者)

17. Zhou X^#, Sun H, Chen H, Zavadil J, Kluz T, Arita A, Costa M*. Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase. Cancer Res. 2010, 70(10): 4214-4221.

18. Arita A^#, Zhou X^#, Ellen TP^#, Liu X, Bai J, Rooney JP, Kurtz A, Klein CB, Dai W, Begley TJ, Costa M*. A genome-wide deletion mutant screen identifies pathways affected by nickel sulfate in Saccharomyces cerevisiae. BMC Genomics. 2009, 10: 524. (^#共同第一作者)

19. Zhou X^#, Arita A^#, Ellen TP^#, Liu X, Bai J, Rooney JP, Kurtz AD, Klein CB, Dai W, Begley TJ, Costa M*. A genome-wide screen in Saccharomyces cerevisiae reveals pathways affected by arsenic toxicity. Genomics. 2009, 94(5): 294-307. (^#共同第一作者)

20. Sun H^#, Zhou X^#, Chen H, Li Q, Costa M*. Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium. Toxicol Appl Pharmacol. 2009, 237(3): 258-266. (^#共同第一作者)

21. Zhou X^#, Li Q, Arita A, Sun H, Costa M*. Effects of nickel, chromate, and arsenite on histone 3 lysine methylation. Toxicol Appl Pharmacol. 2009, 236(1): 78-84.

Zhou X^#, Sun H^#, Ellen TP, Chen H, Costa M*. Arsenite alters global histone H3 methylation. Carcinogenesis. 2008, 29(9): 1831-1836. (^#共同第一作者)