个人简介

2004年毕业于南京大学生物技术专业，获理学学士学位。2009年毕业于中国科学院上海生科院营养所，获理学博士学位。2009年－2012年在美国哈佛大学公共卫生学院从事博士后研究工作。2012－2015年受聘于新加坡国立大学担任助理教授和博士生导师。2015年4月受聘于华中科技大学同济医学院公共卫生学院，担任“华中学者”特聘教授和院长助理。

主要从事营养流行病学和慢性代谢性流行病学方面的研究工作，近年来先后主持和参与美国国立卫生院（NIH）、新加坡卫生部NMRC、国家基金委、科技部重点研发计划等多项科研项目，在营养流行病学和糖尿病研究方面取得了一系列突出研究成果，多次接受新华社、ABC、BBC、CNN、Time、Huffington Post、New York Times、Fox News、USA Today等国际著名媒体采访。共在国际权威期刊发表SCI论文150多篇，论文总影响因子超过1000，被引用次数超过7000次，h-index为46。其中第一作者或者通讯作者文章超过70篇，包括N Engl J Med、JAMA、Cell Metab、PLoS Med、JAMA Intern Med、JAMA Psychiatry、Circulation、Lancet Diabetes & Endocrinol、Diabetes Care等。担任Nutrition & Metabolism、BMC Endocrine Disorders和PLoS ONE等杂志编委，受邀为包括N Engl J Med、JAMA、BMJ、Circulation、Diabetes Care、Am J Clin Nutr等国际顶级杂志审稿超过150次。

研究方向

• 通过前瞻性的队列研究深入探讨肥胖、代谢综合征、2型糖尿病、心脑血管疾病等代谢性疾病的发生发展的主要基因变异和营养等环境因素，以及基因-环境（营养、生活方式等）和基因-表型间的相互作用，建立早期预测和高危个体筛选模型；

• 利用系统流行病学和多组学的方法深入探讨糖尿病的发病机制，寻找新的生物靶点和代谢途径，为个性化医疗和转化医学提供科学支持；

• 对代谢异常高危人群进行营养干预，研究不同营养物质、食物和膳食模式的干预效力，进一步分析遗传和代谢表型的相互作用，探讨个性化营养干预策略；

• 利用流行病学方法研究心理因素（如抑郁和焦虑）和代谢性疾病之间的相互关系，并开展老年性疾病的队列研究工作；

• 系统综述和荟萃分析（营养流行病学和精神病流行病学）

代表性论著

（详见 ResearchID: http://www.researcherid.com/rid/C-5572-2011; Scopus: http://www.scopus.com/authid/detail.url?authorId=23025574700;

Google scholar: http://scholar.google.com/citations?hl=en&user=vSDlcsAAAAAJ ）

1. Li Y,* Pan A,* Wang DD, Liu X, Dhana K, Franco OH, Kaptoge S, Di Angelantonio E, Stampfer M, Willett WC, Hu FB.# Impact of healthy lifestyle factors on life expectancies in the US population. Circulation. 2018;138(4):345-355. doi: 10.1161/CIRCULATIONAHA.117.032047. (*Co-first author)

2. Pan A,* Lin X, Hemler E, Hu FB.* Diet and cardiovascular disease: advances and challenges in population-based studies. Cell Metabolism. 2018;27(3):489-496. (*Co-Corresponding author)

3. Pan XF, He M, Yu C, Lv J, Guo Y, Bian Z, Yang L, Chen Y, Wu T, Chen Z, Pan A,* Li L.* Type 2 diabetes and risk of incident cancers in China: a prospective study among 0.5 million Chinese adults. American Journal of Epidemiology. 2018;187(7):1380-1391. (*Co-Corresponding author)

4. Yuan Y, Xiao Y, Feng W, Liu Y, Zhou L, Qiu G, Wang H, Liu B, Liu K, Yang H, Li X, Min X, Zhang C, Xu C, Zhang X, He M, Hu FB, Pan A,* Wu T.* Plasma metal concentrations and incident coronary heart disease in Chinese adults: the Dongfeng-Tongji Cohort. Environmental Health Perspectives. 2017;125(10):107007. (*Co-Corresponding author)

5. Qiu G, Zheng Y, Wang H, Sun J, Ma H, Xiao Y, Li Y, Yuan Y, Yang H, Li X, Min X, Zhang C, Xu C, Jiang Y, Zhang X, He M, Yang M, Hu Z, Tang H, Shen H, Hu FB, Pan A,* Wu T.* Plasma metabolomics identified novel metabolites associated with risk of type 2 diabetes in two prospective cohorts of Chinese adults. International Journal of Epidemiology. 2016;45(5):1507-1516. (*Co-Corresponding author)

6. Lu Y, Wang Y, Ong CN, Subramaniam T, Choi HW, Yuan JM, Koh WP,* Pan A.* Metabolic signatures and risk of type 2 diabetes in a Chinese population: an untargeted metabolomics study using both LC-MS and GC-MS. Diabetologia. 2016;59(11):2349-2359. (*Co-Corresponding author)

7. Pan A,* Wang Y,* Talaei M, Hu FB, Wu T. Relation of active, passive, and quitting smoking with type 2 diabetes: a meta-analysis and systematic review. Lancet Diabetes & Endocrinology. 2015;12(3):958-967. (*Co-first author and Corresponding author)

8. Pan A, Wang Y, Talaei M, Hu FB. Relation of smoking with total mortality and cardiovascular events among patients with diabetes: a meta-analysis and systematic review. Circulation. 2015;132(19):1795-1804. (Corresponding author)

9. Tobias D,* Pan A,* Jackson CL, Ding EL, O’Reilly EJ, Willett WC, Manson JE, Hu FB. Body-mass index and mortality among adults with incident type 2 diabetes. New England Journal of Medicine. 2014;370:233-244. (*Co-first author and Co-corresponding author)

10. Pan A,* Clark ML, Ang LW, Yu MC, Yuan JM, Koh WP.* Incense use and cardiovascular mortality among Chinese in Singapore: The Singapore Chinese Health Study. Environmental Health Perspectives. 2014;122(12):1279–1284.(*Co-Corresponding author)

11. Pan A,* Kawachi I, Luo N, Manson JE, Willett WC, Hu FB, Okereke OI. Changes in body weight and health-related quality of life: two cohorts of US women. American Journal of Epidemiology. 2014;180(3):254-262. (*First and corresponding author)

12. Pan A,* De Silva DA, Yuan JM, Koh WP. Sleep duration and risk of stroke mortality among Chinese adults: the Singapore Chinese Health Study. Stroke. 2014;45(6):1620-1625.

13. Pan A, Malik V, Hao T, Willett WC, Mozaffarian D, Hu FB. Changes in water and beverage intake and long-term weight changes: results from three prospective cohort studies. International Journal of Obesity. 2013;37(10):1378-1385.

14. Pan A, Sun Q, Bernstein AM, Manson JE, Willett WC, Hu FB. Changes in red meat consumption and subsequent risk of type 2 diabetes: three cohorts of US men and women. JAMA Internal Medicine. 2013;173(14):1328-1335.

15. Pan A, Keum N, Okereke OI, Sun Q, Kivimaki M, Rubin RR, Hu FB. Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studies. Diabetes Care. 2012;35:1171-1180.

16. Pan A, Sun Q, Bernstein AM, Schulze MB, Manson JE, Stampfer MJ, Willett WC, Hu FB. Red meat consumption and mortality: results from 2 prospective cohort studies. Archives of Internal Medicine. 2012;172:555-563.

17. Pan A, Malik V, Schulze MB, Manson JE, Willett WC, Hu FB. Plain-water intake and risk of type 2 diabetes in young and middle-aged women. American Journal of Clinical Nutrition. 2012;95:1454-1460.

18. Pan A, Chen M, Chowdhury R, Wu JHY, Sun Q, Campos H, Mozaffarian D, Hu FB. Alpha-linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis. American Journal of Clinical Nutrition. 2012;96: 1262-1273.

19. Pan A, Sun Q, Bernstein AM, Schulze MB, Manson JE, Willett WC, Hu FB. Red meat consumption and risk of type 2 diabetes: three cohorts of U.S. adults and an updated meta-analysis. American Journal of Clinical Nutrition. 2011;94(4):1088-1096.

20. Pan A, Sun Q, Okereke OI, Manson JE, Rexrode KM, Hu FB. Depression and the risk of stroke morbidity and mortality: a systematic review and meta-analysis.JAMA. 2011;306(11):1241-1249.

21. Pan A, Schernhammer ES, Sun Q, Hu FB. Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in women. PLoS Medicine.2011;8(12):e1001141.

22. Pan A, Lucas M, Sun Q, van Dam RM, Franco OH, Willett WC, Manson JE, Rexrode KM, Ascherio A, Hu FB. Increased mortality risk in women with depression and diabetes mellitus. Archives of General Psychiatry.2011;68(1):42-50.

23. Pan A, Lucas M, Sun Q, van Dam RM, Franco OH, Manson JE, Willett WC, Ascherio A, Hu FB. Bidirectional association between depression and type 2 diabetes in women. Archives of Internal Medicine. 2010; 70(21):1884-1891.

24. Pan A, Yu D, Demark-Wahnefried W, Franco OH, Lin X. Meta-analysis of the effects of flaxseed interventions on the blood lipids. American Journal of Clinical Nutrition. 2009;90(2):288-297.