Dr. Li Liu is Associate Professor of Epidemiology and Biostatistics, School of Public Health, Huazhong University of Science & Technology (HUST). She graduated with a major in Preventive Medicine in 2007 and received her PhD in 2012 from Huazhong University of Science and Technology. Dr. Liu’s research is mainly focused on molecular epidemiology of colorectal cancer. Currently she is undertaking programs from the National Natural Science Foundation and the Ministry of Education to detect the whole genome wide gene expression related copy number variation in the susceptibility of colorectal cancer. She has published 16 original papers as the first or corresponding author, with total IF more than 60. Dr. Liu is the recipient of the Provincial Second Awards of Scientific Advancement as the second contributor.

Education

2002/09-2007/06  Bachelor’s Degree of Medicine

The Faculty of Preventive Medicine
Tongji Medical University

2007/09-2012/06  Doctoral Degree of Medicine

Dept. of Epidemiology and Biostatistics
Tongji Medical University
Huazhong University of Science and Technology

Languages

Chinese, English

Work Experience

2012/10-2015/11  Lecturer

Dept. of Epidemiology and Biostatistics
School of Public Health
Tongji Medical University
Huazhong University of Science and Technology

2015/12-  Associate Professor
Dept. of Epidemiology and Biostatistics
School of Public Health
Tongji Medical University
Huazhong University of Science and Technology

2016.1- Postdoctor
Lab. of Molecular Pathology Epidemiology
(Prof Shuji Ogino)
Dana-Farber Cancer Institute
Harvard Medical College
Harvard University

2016.1- Postdoctor
Dept. Nutrition
(Prof Edward Giovannucci)
Harvard T.H.Chan School of Public Health
Harvard University

Previous Research Funding

2013-2014 Genetic polymorphisms in Telomerase gene, Telomere length in the susceptibility of gallbladder carcinoma, University Foundation (2013QN001). (PI).

Present Active Research Programs

2014-2016 Genome-wide expression profiling-based copy number variations in the initiation and development of colorectal cancer, National Natural Science Foundation of China (230,000RMB). (PI).

2014-2016 Genome-wide expression profiling-based copy number variations in the susceptibility of colorectal cancer, Doctoral Foundation from Ministry of Education of the People’s Republic of China (50,000RMB). (PI)

Career goals

1. Gene-environment interaction in the initiation and development of colorectal cancer

2. Carcinogenesis and biomarkers of colorectal cancer

2 Genetic susceptibility of Colorectal Cancer

Publications in peer-reviewed journals (in English)

1. Liu L, Huang J, Wang K, Li L, Li Y, Yuan J, Wei S. Identification of hallmarks of lung adenocarcinoma prognosis using whole genome sequencing. Oncotarget. 2015 Nov 10;6(35):38016-28. doi: 10.18632/oncotarget.5697.

2. Li T, Wei S, Shi Y, Pang S, Qin Q, Yin J, Deng Y, Chen Q, Wei S, Nie S, Liu L. The dose-response effect of physical activity on cancer mortality: findings from 71 prospective cohort studies. Br J Sports Med. 2015 Sep 18. pii: bjsports-2015-094927.

3. Liu L, Shi Y, Li T, Qin Q, Yin J, Pang S, Nie S, Wei S. Leisure time physical activity and cancer risk: evaluation of the WHO’s recommendation based on 126 high-quality epidemiological studies. Br J Sports Med. 2015 Oct 23. pii: bjsports-2015-094728. doi: 10.1136/bjsports-2015-094728.

4. Shi Y, Li T, Wang Y, Zhou L, Qin Q, Yin J, Wei S, Liu L, Nie S. Household physical activity and cancer risk: a systematic review and dose-response meta-analysis of epidemiological studies. Sci Rep. 2015 Oct 7;5:14901. doi: 10.1038/srep14901. (co-corresponding author)

5. Liu L, Zhong R, Wei S, Xiang H, Chen J, Xie D, Yin J, Zou L, Sun J, Chen W, Miao X, Nie S. The leptin gene family and colorectal cancer: interaction with smoking behavior and family history of cancer. PLoS One. 2013 Apr 8;8(4):e60777. doi: 10.1371/journal.pone.0060777.

6. Liu L, Zhong R, Wei S, Yin J, Xiang H, Zou L, Chen W, Chen J, Zheng X, Huang L, Zhu B, Chen Q, Duan S, Rui R, Yang B, Sun J, Xie D, Xu Y, Miao X, Nie S. Interactions between Genetic Variants in the Adiponectin, Adiponectin Receptor 1 and Environmental Factors on the Risk of Colorectal Cancer. PLoS One 2011;6(11):e27301. doi: 10.1371/journal.pone.0027301.

7. Liu L, Wu J, Wu C, Zhong R, Zhang X, Tan W, Nie S, Miao X, Lin D. A functional polymorphism (-1607 1G→2G) in the matrix metalloproteinase-1 promoter is associated with development and progression of lung cancer. Cancer 2011 Nov 15;117(22):5172-81. doi: 10.1002/cncr.26154.

8. Liu L, Yuan P, Liu L, Wu C, Zhang X, Guo H, Zhong R, Xu Y, Wu J, Duan S, Rui R, Wu T, Nie S, Miao X, Lin D. A functional -77T>C polymorphism in XRCC1 is associated with risk of breast cancer. Breast Cancer Res Treat 2011 Jan;125(2):479-87. doi: 10.1007/s10549-010-0959-z.

9. Liu L, Wu J, Zhong R, Wu C, Zou L, Yang B, Chen W, Zhu B, Duan S, Yu D, Tan W, Nie S, Lin D, Miao X. Multi-loci analysis reveals the importance of genetic variations in sensitivity of platinum-based chemotherapy in non-small-cell lung cancer. Mol Carcinog. 2013 Dec;52(12):923-31. doi: 10.1002/mc.21942.

10. Qin Q, Liu L, Zhong R, Zou L, Yin J, Zhu B, Cao B, Chen W, Chen J, Li X, Li T, Lu X, Lou J, Ke J, Wei S, Miao X, Nie S. The genetic variant on chromosome 10p14 is associated with risk of colorectal cancer: results from a case-control study and a meta-analysis. PLoS One. 2013 May 22;8(5):e64310. doi: 10.1371/journal.pone.0064310. (co-first author)

11. Li T, Shi Y, Yin J, Qin Q, Wei S, Nie S, Liu L. The association between lipid metabolism gene polymorphisms and nephropathy in type 2 diabetes: a meta-analysis. Int Urol Nephrol. 2015 Jan;47(1):117-30. doi: 10.1007/s11255-014-0843-6. (co-corresponding author)

12. Zhou L, Yu L, Wang Y, Lu Z, Tian L, Tan L, Shi Y, Nie S, Liu L. A hybrid model for predicting the prevalence of schistosomiasis in humans of Qianjiang City, China. PLoS One 2014;9(8):e104875. doi: 10.1371/journal.pone.0104875. (co-corresponding author)

13. Fan Y, Yang M, Jiang H, Wang Y, Yang W, Zhang Z, Yan W, Diwan VK, Xu B, Dong H, Palm L, Liu L, Nie S. Estimating the effectiveness of early control measures through school absenteeism surveillance in observed outbreaks at rural schools in Hubei, China. PLoS One. 2014 Sep 24;9(9):e106856. doi: 10.1371/journal.pone.0106856. (co-corresponding author)

14. Jiang H, Xie N, Cao B, Tan L, Fan Y, Zhang F, Yao Z, Liu L, Nie S. Determinants of Progression to AIDS and Death Following HIV Diagnosis: A Retrospective Cohort Study in Wuhan, China. PLoS One 2013 Dec 23;8(12):e83078. doi: 10.1371/journal.pone.0083078. (co-corresponding author)

15. Zhao H, Yin JY, Yang WS, Qin Q, Li TT, Shi Y, Deng Q, Wei S, Liu L, Wang X, Nie SF. Sleep Duration and Cancer Risk: a Systematic Review and Meta-analysis of Prospective Studies. Asian Pac J Cancer Prev. 2013;14(12):7509-7515. (co-corresponding author)

16. Chen D, Liu L, Xiao Y, Peng Y, Yang C, Wang Z. Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians. Drug and Alcohol Dependence. doi:10.1016/j.drugalcdep.2011.10.012（Co-first author）

17. Zhong R, Liu L, Zou L, Sheng W, Zhu B, Xiang H, Chen W, Chen J, Rui R, Zheng X, Yin J, Duan S, Yang B, Sun J, Lou J, Liu L, Xie D, Xu Y, Nie S, Miao X. Genetic variations in the TGFβ signaling pathway, smoking and risk of colorectal cancer in a Chinese population. Carcinogenesis. 2013;34(4):936-942.

18. Xiang H, Liu L, Chu G, Wei S, Liu J, Xu Y, Chen J, Wang C, Wei Q, Nie S. Association between two functional polymorphisms of insulin-like growth factor binding protein 3 and colorectal cancer risk in a Chinese population. J Toxicol Environ Health A. 2009;72:706-711

19. Zhang Y, Liu L, Tang Y, Chen C, Wang Q, Xu J, Yang C, Miao X, Wei S, Chen J, Nie S. Polymorphisms in TP53 and MDM2 contribute to higher risk of colorectal cancer in Chinese population: a hospital-based, case-control study. Mol Biol Rep 2012;39(10):9661-9668.

20. Yin J, Li Y, Yin M, Sun J, Liu L, Qin Q, Li X, Long L, Nie S, Wei S. TERT-CLPTM1L polymorphism rs401681 contributes to cancers risk: evidence from a meta-analysis based on 29 publications. PLoS One. 2012;7(11):e50650.

21. Jiang H, Yin J, Fan Y, Liu J, Zhang Z, Liu L, Nie S. Gender difference in advanced HIV disease and late presentation according to European consensus definitions. Sci Rep. 2015;5:14543. doi: 10.1038/srep14543.

22.Cao B, Jiang H, Xiang H, Lin B, Qin Q, Zhang F, Kong W, Wei S, Liu L, Yan W, Nie S. Prevalence and influencing factors of depressive symptoms among women of reproductive age in the rural areas of Hubei, China. Public Health. 2015;129(5):465-474.

23. Jiang H, Xie N, Fan Y, Zhang Z, Liu J, Yu L, Yang W, Liu L, Yao Z, Wang X, Nie S. Risk Factors for Advanced HIV Disease and Late Entry to HIV Care: National 1994-2012 HIV Surveillance Data for Wuhan, China. AIDS Patient Care STDS. 2015;29(10):541-549.

Honor & Awards

2014 Hubei Provincial science and technological progression award

2014 Excellent scientific publication of Wuhan City
2011 The medical scholarship of Qiu Fazu
2008 Science and technology achievement award of Wuhan City
2007 Excellent bachelor’s thesis of Hubei Province