09/2009-07/2014　Doctoral Degree of Philosophy

       State Key Laboratory of Molecular Oncology,
       Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union MedicalCollege,Beijing, China
       Advisor: Dr. Dongxin Lin

09/2005-07/2009　Bachelor’s Degree of Biological Science

       College of Life Science

       Nankai University, Tianjin, China

Languages

Chinese, English

Work experience

 07/2014-11/2017     Assistant Professor

School of Public Health

Tongji Medical College

Huazhong University of Science & Technology

 11/2017-present     Associate Professor

                        School of Public Health

                        Tongji Medical College

                        Huazhong University of Science & Technology

Present Active Research Programs

1. Functional analysis based fine-mapping of GWAS identified colorectal susceptible loci 10q22.3. Supported by NSFC, From 2016/01-2018/12 (180,000 RMB). (PI).

2. Study of association between genetic variants affecting protein phosphorylation level and susceptibility to esophageal squamous cell carcinoma. Supported by NSFC, From 2019/01-2022/12 (580,000 RMB). (PI).

Publications

1. Chang J^#, Zhong R^#, Tian J^#, Li J^#, et al. Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma. Nat Genet 50, 338-343 (2018).

2. Chang J^#, Tian J^#, Zhu Y^#, Zhong R^#, et al. Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations. Nat Commun 9, 3688 (2018)

3. Yang Y, et al, Chang J*, Miao X*. AWESOME: A database of SNPs that affect protein post-translational modifications. Nucleic Acids Research (2018). (*Corresponding author)

4. Chang J^#, Tian J^#, Yang Y^#, Zhong R^#, et al. A rare missense variant in TCF7L2 associates with colorectal cancer risk by interacting with a GWAS-identified regulatory variant in the MYC enhancer. Cancer Res 78(17), 5164-5172 (2018).

5. Chang J^#, Tan W^#, Ling Z^#, Xi R^#, Shao M^#, Chen M^#, et al. Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations. Nat Commun 8, 15290 (2017).

6. Li J, Wang Y, et al, Zhong R* & Chang J*. Breast cancer risk-associated variants at 6q25.1 influence risk of hepatocellular carcinoma in a Chinese population. Carcinogenesis 38, 447-454 (2017). (*Corresponding author)

7. Chang J^#, Wei L^#, et al. Two novel variants on 13q22.1 are associated with risk of esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 24, 1774-80 (2015).

8. Chang J, et al. Risk prediction of esophageal squamous-cell carcinoma with common genetic variants and lifestyle factors in Chinese population. Carcinogenesis 34, 1782-6 (2013).

9. Tan D E^#, Foo J N^#, Bei J X^#, Chang J^#, et al. Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population. Nat Genet 45, 804-7 (2013).

10. Wu C^#, Kraft P^#, Zhai K^#, Chang J^#, et al. Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Nat Genet 44, 1090-7 (2012).