常江，男，1986年8月生，教授，博士生导师，国家“万人计划”青年拔尖人才计划入选者，中国科协青年人才托举项目入选者。2009年毕业于南开大学生物科学专业，2014年获得中国医学科学院肿瘤学博士学位，师从著名肿瘤学专家林东昕院士。2014年7月在华中科技大学同济医学院公共卫生学院工作，先后任讲师、副教授，2019年破格晋升为教授。

主要研究领域

    肿瘤及其他慢性非传染性疾病的分子流行病学。通过大规模、多中心的人群研究和系统、全面的分子生物学研究，揭示了食管癌、胰腺癌和结直肠癌等恶性肿瘤易感基因和基因-环境交互作用，为肿瘤的防治提供了新的线索和依据。截至2018年，以第一作者或通讯作者在包括Nat Genet, Nat Commun, Cancer Res, Nucleic Acids Research、Carcinogenesis等国内外权威期刊发表论文10余篇。目前担任中国抗癌协会肿瘤病因学专业委员会委员、中国环境诱变剂学会理事会理事。目前主要的研究方向为结合人群大数据寻找可以应用于消化系统肿瘤个体化预防的分子标志物。

代表性论著

1. Chang J^#, Zhong R^#, Tian J^#, Li J^#, et al. Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma. Nat Genet 50, 338-343 (2018).

2. Chang J^#, Tian J^#, Zhu Y^#, Zhong R^#, et al. Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations. Nat Commun 9, 3688 (2018)

3. Yang Y, et al, Chang J*, Miao X*. AWESOME: A database of SNPs that affect protein post-translational modifications. Nucleic Acids Research (2018). (*Corresponding author)

4. Chang J^#, Tian J^#, Yang Y^#, Zhong R^#, et al. A rare missense variant in TCF7L2 associates with colorectal cancer risk by interacting with a GWAS-identified regulatory variant in the MYC enhancer. Cancer Res 78(17), 5164-5172 (2018).

5. Chang J^#, Tan W^#, Ling Z^#, Xi R^#, Shao M^#, Chen M^#, et al. Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations. Nat Commun 8, 15290 (2017).

6. Li J, Wang Y, et al, Zhong R* & Chang J*. Breast cancer risk-associated variants at 6q25.1 influence risk of hepatocellular carcinoma in a Chinese population. Carcinogenesis 38, 447-454 (2017). (*Corresponding author)

7. Chang J^#, Wei L^#, et al. Two novel variants on 13q22.1 are associated with risk of esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 24, 1774-80 (2015).

8. Chang J, et al. Risk prediction of esophageal squamous-cell carcinoma with common genetic variants and lifestyle factors in Chinese population. Carcinogenesis 34, 1782-6 (2013).

9. Tan D E^#, Foo J N^#, Bei J X^#, Chang J^#, et al. Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population. Nat Genet 45, 804-7 (2013).

10. Wu C^#, Kraft P^#, Zhai K^#, Chang J^#, et al. Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Nat Genet 44, 1090-7 (2012).