Dr. Tangchun Wu is tenured Professor of Occupational and Environmental Health, the Dean of School of Public Health, vice-dean of Tongji Medical College, Huazhong University of Science & Technology (HUST), and National Outstanding Young Investigator, the Yangzi Scholarship and Principal Investigator (PI) of a 973 Program (the National Key Basic Research and Development Program). He graduated with a major in Preventive Medicine in 1988 and received his PhD in 1993 from Tongji Medical College. Dr. Wu’s research is mainly focused on effects of air pollution and interaction between environment and genes on cytokines, immune responses, genetic, epigenetic and environment-related diseases (especially coronary heart disease and lung cancer) and the corresponding mechanisms. Currently he is leading a 973 Project to investigate health hazards caused by ambient particulate matter and serves as PI of the Dongfeng-Tongji Cohort Study (DFTJ cohort) in Dongfeng Motor Corporation (DMC). He has published over 400 original papers (180 of them published in SCI-collected journals including J Clin Oncol, Circulation, Environ Health Perspect, PloS Med, GUT and Nature Genetics). Dr. Wu has served as Chair, co-Chair for many times, or keynote speaker at International Conferences on Occupational and Environmental Health, and Cell Stress. Dr. Wu is the recipient of the National Second Awards of both Natural Science and Scientific Advancement.

Education

1983/09-1988/07 Bachelor’s Degree of Medicine The Faculty of Preventive Medicine Tongji Medical University

1988/09-1990/07 Master’s Degree of Medicine Dept. of Labor Health and Occupational Diseases Tongji Medical University (one year ahead for excellent achievement)

1990/09-1993/07 Doctoral Degree of Medicine Dept. of Labor Health and Occupational Diseases Tongji Medical University Languages: Chinese, English, A little German

Work Experience

1993/07-1993/12 Assistant professor Institute of Occupational Medicine School of Public Health Tongji Medical University

1994/01-1994/08 Visiting scientist Lab. of Molecular Genetics (National Key Lab) Huazhong Agriculture University (Wuhan)

1994/09-1995/11 Associate professor Institute of Occupational Medicine Tongji Medical University

1995/12 Exchange scientist supported by Medical Research Council of Canada and National Natural Scientific Foundation of China Lab. of Molecular and Development Genetics (Prof R.M. Tanguay) Research Center in Health and Life Sciences (RSVS Pavillon Marchand, Laval University Ste-Foy, Qc, Canada

1996/01-1996/12 Post-doctoral fellowship Lab. of Molecular and Development Genetics (Prof R.M. Tanguay) Research Center in Health and Life Sciences (RSVS) Pavillon Marchand, Laval University Ste-Foy, Qc, Canada

1997/01-1997/12 Associate professor Institute of Occupational Medicine School of Public Health Tongji Medical University

1998/01-1998/05 Visiting Professor Lab. of Molecular and Development Genetics (Prof R. M. Tanguay) Dep. Medicine, Pavillon Marchand, Laval University Ste-Foy, Qc, Canada

1999/01- 1999/03 Visiting Professor Lab. of Molecular and Development Genetics (Prof R. M. Tanguay) Dep. Medicine, Pavillon Marchand, Laval University Ste-Foy, Qc, Canada

1999/03-1999/12 Associate professor Institute of Occupational Medicine School of Public Health Tongji Medical University

2001/05- 2006/05 Professor and Director Institute of Occupational Medicine; School of Public Health Tongji Medical College Huazhong University of Science & Technology

2006/05- present Professor in Department of Environmental and Occupational, Health and Ministry of Education Key Lab for Environment and Health Dean, School of Public Health Tongji Medical College Huazhong University of Science & Technology

Studies and Previous Research Funding

1. Studies on body damage mechanisms to workers working in the extremely hot environment and on preventive measures. Supported by funds from Ministry of Health, China.

2. Study on the relationship between blood lipids and coronary heart diseases. Cooperation research program between Germany and China (400,000 DM).

3. Study on the relationship between heat shock proteins and the health of workers working in extremely hot environment. Supported by funds from the Ministry of Health, China.

4. The effects of city heat island on the health of residents. Supported by funds from the Ministry of Health, China.

5. The regulation of heat shock genes and thermal-resistant microorganisms used in the industry. Supported by the Scientific Conference of Wuhan.

6. Study on the relationship between silicosis and lung cancer. Cooperation research program between National Cancer Institute of USA and Institute of Occupational Medicine, Tongji Medical University, China (500,000$).

7. Study on the relationship between oncogenes and leukaemia induced by benzene. Supported by the National Natural Scientific Foundation of China (NNSFC) and the exchange and cooperation program supported by both Medical Research Council of Canada (MRC) and NNSFC.

8. The roles of heat shock proteins and acute phase response proteins play in heat injury. Supported by NNSFC.

9. The biological monitoring of 7-methyl-guanine in workers. Supported by NNSFC.

10. The early monitoring and screening biomarkers of occupational lung cancer. Supported by NNSFC.

11. The relationship between heat shock proteins and heat shock response. Supported by NNSFC and the MRC of Canada (exchange program).

12. The study on the relationship between heat stress proteins and DNA damage caused by different carcinogens. Exchange and cooperation program supported by Medical Research Council of Canada (MRC) and NNSFC. (PI)

13. The relationship among main heat stress proteins, gene damage and cell apoptosis caused by alkylogens. Supported by NNSFC and a cooperation program of the Medical Research Council of Canada (MRC) and NNSFC. From 1998/01 to 2000/12 (PI)

14. The biological significance of HSP60, 71 and 90 and their antibodies in workers and patients. Supported by both National Educational Commission and Ministry of Health of China. From 1998/01 to 2000/12(PI)
15. The carcinogenesis and early screening biomarkers in occupational lung cancer. Supported by The Scientific and Technique Committee of Hubei Province. From 1997/01 to 2000/12 (Co-PI)

16. The biomedical significance of heat stress proteins in health and diseases. Supported by Ministry of Health of China. From 1999/011 to 2001/12 (PI)

17. The detection of Hsp71 and its antibodies in the blood and their possible importance. Supported by The Scientific and Technique Committee of Wuhan. From 1999/12 to 2002/12. (PI)

18. The polymorphism of heat stress protein 70kD genes and expression, and its correction with thermotolerance. Supported by Fox He Foundation. From 2000/012002/12. (14,000 US $)(PI)

19. The polymorphism of heat stress protein 70kD genes and expression, and its significance in heat injury. Supported by NNSFC and a cooperation program of the Canadian Institute Health Research (CIHR) and NNSFC. From 2001/01 to 2003/12. (150,000 RMB). (PI)

20. Study on interaction of environmental factors, nutrients and genetic factors and its significance in coronary heart diseases. Supported by NNSFC. From 2002/01 to 2004/12. (400,000 RMB). (Co-PI with Frank B Hu, Harvard School Of Public Health)

21. The gene regulation of heat shock protein 71 under benzo alpha pyrene and its significance. Supported by Ministry of Education. From 2001/01-2005/12. (500,000 RMB).(PI)

22. Epitope of autoantibody against Hsp70 and its possible biomedical significance in workers exposed to different types of occupational harmful factors. Supported by NNSFC. From 2003/01 to 2005/12. (200,000RMB). (Co-PI).

23. A case control study of cytokine gene variation and myocardial infarction in a Chinese population. Supported by Interleukin Genetics, Inc. of Waltham, Massachusetts, From 2006/01-2007/12, (165,000USD). (PI)

24. Study on Grading method of heat in deep wells. Supported by Ministry of Science and Technology, China. From 2006/12-2008/12, (1,200,000 RMB). ( PI)

25. Study on the roles of response proteins in damage and defense of living things caused by environmental chemical pollutants (BaP, CO, Pb). Supported by research funds from the National Key Basic Research and Development Program (2002CB512905). From 2002/12-2007/12. ( 2,040,000 RMB) (PI).

26. Roles of Hsp27 and Hsp70 in environment-related lung cancer and chronic obstructive pulmonary diseases. Supported by NSFC (Chinese Outstanding Young Scientist Fund). From 2006/01-2009/12 (1,600,000 RMB). (PI).

27. Association of genetic variations in Hsp70 genes and antibodies to Hsps with coronary heart disease. Supported by NSFC (China) and CIHR (Canada), From 2008/01-2010/12 ( 450,000RMB +90,000 Can $). (PI)

28. The role and possible mechanism of interaction between Hsp70 and CK-II in DNA damage and repair caused by benzo a pyrene. Supported by NSFC, From 2009/012011/12 (360,000 RMB). (PI).

29. Genome-wide association studies of lung cancer. Supported by Ministry of Science & Technology, From 2009/01-2010/12 (18,840,000 RMB). (Co-PI).

30. Genetic biomarkers for the exposure to formaldehyde. Supported by Ministry of Health. From 2008/01-2011/12 (300,000 RMB). (PI).

31. The criteria of check-up for workers exposed to coking oven emissions. Supported by Ministry of Science & Technology. From 2010/01-2012/12 (690,000 RMB). (PI).

32. Basic studies on health hazards caused by ambient particulate matter. Supported by research funds from the National Key Basic Research and Development Program (2011CB503800). From 2011/1-2015/08. (27, 900, 000 RMB) (PI).

33. Air Pollution, Lifestyle, and Public Health in China: The Dongfeng-Tongji Cohort Study. Supported by Chinese Medical Board, From 2013/01-2015/12 (300,000 US $). (PI).

Present Active Research Programs

1. The role and possible mechanism of environment (life style), genes and their interactions in the development of coronary heart diseases. Supported by NSFC, From 2013/01-2017/12 (2,700,000 RMB). (PI).

2. Risk prediction of coronary heart disease and ischemic stroke based on a prospective Chinese mega-cohort study. Supported by NSFC, From 2014/012018/12 (3,900,000 RMB). (PI). Career goals 1. Biological significance of heat shock proteins and their related proteins in the stresses or diseases with the techniques of molecular and cellular biology, toxicology, epidemiology and others. 2. Carcinogenesis and biomarkers of occupational and environmental related lung cancer and coronary heart diseases

3. Occupational, environmental exposures and coronary heart diseases in cohort.

4. Environments, genes and their interaction on the cardiopulmonary injury and diseases.

i- Publications in peer-reviewed journals (in English)

1. Wu T*, He Hanzhen, Tanguay Robert M.,Wu Yang, Xu Daigen, Currie R.W., Qu Shen, Fend Jiade, Zhang Guogao. The combined effects of high temperature and carbon monoxide on heat stress response. J. Tongji Med. Univ, 14(3):178 – 183, 1995.

2. Wu T*, Tanguay, R.M.,Wu Yang, He Hanzhen, Xu Daigen, Feng Jiade, Shi Wuxiang and Zhang Guo gao. : Presence of antibodies to heat shock proteins and its possible significance in workers exposed to high temperature and carbon monoxide. Biomed and Environ Sci 9:370-379, 1996.

3. Xiong Yili, Wu T*, Yongxing Zhang, Tanguay R.M., Nicole L., Yuan Ye and Zhang GuoGao. : Preliminary studies on the relationship between autoantibodies to heat stress proteins and heat injury of pilots during acute heat stress. J. Tongji Med. Univ. 17(2):83-85, 1997.

4. Wu T*, Wu Yang, Yuan Ye and He Hanzhen. : Analysis of amino acid composition of purified HSP70 and free amino acid in plasma of workers exposed high temperature, carbon monoxide and both. J Tongji Med Univ 18(4):204-207, 1998.

5. Wu T*., He, H., Wu, Y., Xu, D., Feng, J., Shi, W., Yuan, Y., Zhang, G. and Tanguay, R M.: Antibodies to heat stress proteins (hsps) in workers exposed to high temperatures, carbon monoxide and benzene. Annals N.Y. Acad Sci 851: 511-515, 1998.

6. Wu T*, Yuan Ye, Wu Yang, He Hanzhen, Zhang Guogao and Tanguay R. M.: Presence of antibodies to heat stress proteins in workers exposed to benzene and in patients with benzene-poisoning. Cell Stress and Chaperones 3:161-167, 1998.

7. Wu T*, Yuan Ye, Yongyi Bi, He Hanzhen and Zhang Guogao. : Plasma free amino acids of workers working under different stress conditions. J Occup Health. 40:203-206, 1998.

8. Wu T*, Yili Xiong, Sheng Chen, Leng Shuntang, Hai Tao and Robert M. Tanguay. : Biochemical changes in plasma of paratroops after parachuting: a preliminary investigation. Space Med & Medical Engineering 12(4):235-239, 1999.

9. Wu T*, Sheng Chen, Chengfeng Xiao, Changlai Wang, Qin Pan, Zizheng Wang, Meiyun Xie, Zhicheng Mao, Yang Wu, and Robert M. Tanguay. Presence of antibody against the inducible Hsp71 in patients with acute heat-induced illness. Cell Stress & Chaperones, 6(2): 113–120, 2001.

10. Wu T*, Jinxiang Ma, Sheng Chen, Yehuan Sun, Chengfeng Xiao, Yajuan Gao, Ruibo Wang, Jacques Poudrier, Michele Dargis, R. William Currie, and Robert M. Tanguay. Association of plasma antibodies against the inducible Hsp70 with hypertension and harsh working conditions. Cell Stress & Chaperones 6(4): 394–401, 2001(Cover Page)

11. Wang ZZ, Wang CL, Wu T, Pan HN, Wang SK and Jiang JD. Autoantibody response to heat shock protein 70 in patients with heatstroke. Am J Med 111: 654-657, 2001.

12. Xiao C, Chen S, Li J, Hai T, Lu Q, Sun E, Wang R, Tanguay RM, Wu T*. Association of HSP70 and genotoxic damage in lymphocytes of workers exposed to coke-oven emission. Cell Stress & Chaperones 7: 396-402, 2002. (Cover Page)

13. Zhang BY, Chen S, Ye FL, Zhu CC, Zhang HX, Wang RB, Xiao CF, Wu T, Zhang GG. Effect of manganese on heat stress protein synthesis of new-born rats. World J Gastroenterol. 2002 8(1): 114-8

14. Xiao C, Wu T*, Ren A, Pan Q, Chen S, Wu F, Li X, Wang W, Hightower LE, Tanguay RM. Basal and inducible levels of Hsp70 in patients with acute heatinduced illness induced during training. Cell Stress & Chaperones 8: 86-92, 2003.

15. GaoY, Xiao C, Chen S, Wang R, He H, Tanguay RM, Wu T*. In vitro study on the role of Hsp70 expression in DNA damage in human embryonic lung cells exposed to benzo(a)pyrene. Biomed Environ Sci 7(2): 36-44, 2004

16. Jin X, Wang R, Xiao C, Cheng L, Wang FR, Yang L, Feng T, Chen M, Chen S, Fu X, Deng J, Wang R, Tang F, Wei Q, Tanguay RM, Wu T*. Serum and lymphocyte levels of Hsp7l in aging: a study in the normal Chinese population. Cell Stress & Chaperones,2004: 9(1):69-75

17. Jin X, Xiao C, Tanguay RM, Yang L, Wang F, Chen M, Fu X, Wang R, Deng J, Deng J, Zheng Y, Wei Q, Wu T*. Correlation of lymphocyte Hsp70 levels with neurological deficits in elder patients with cerebral infarction. Am J Med. 2004,117:406-411

18. Yang M, Zheng J, Tan H, Yang Q, Wang F, Yao H, Chen Y, Jiang C, He M, Chen S, Wei Q, Tanguay RM, Wu T*. Frequency-Specific association of antibodies against heat shock protein 60 and 70 with noise-induced hearing loss in workers. Cell Stress and Chaperones.2004, 9(2): 206-213

19. Xiao C, Chen S, Yuan Y, Ding F, Yang D, Wang, Li J, Tanguay RM, Wu T*. Expression of Hsp60 and Hsp70 and presence of antibodies against Hsp70 in child patients with immune thrombocytopenic purpura. BMC Blood Disorders, 2004:4:1(March 02)

20. Currie RW, Wu T, Tanguay RT. Stress under the dam: Meeting report of the Fourth International Workshop on the Molecular Biology of Stress Responses. Cell Stress and Chaperones. 2004, 9(3): 221-228

21. Xu YF, Zhang YJ, Zhang AH, Zhang Q, Wu T, Wang JZ. Attenuation of okadaic acid-induced hyperphosphorylation of cytoskeletal proteins by heat preconditioning and its possible underlying mechanisms. Cell Stress Chaperones. 2004，9(3):304-312.
22. Yang M, Wu T*, Cheng L, Wang F, Chen S, Wei Q, Tanguay RM. Plasma antibody against inducible heat shock protein 70 associated with risk and severity of asthma. Resp Res 2005,6(1): 18

23. Yuan J, Yang M, Yao H, Zheng J, Yang Q, Chen S, Wei Q, Tanguay RM, Wu T*. Association of plasma antibodies against Hsp60 and Hsp70 with increased risk of electrocardiograph abnormality in Chinese automobile workers. Cell Stress and Chaperones, 2005, 10(2): 126-135

24. Zhou F, Li F, Jiang C, Sun S, Zhang S, Liao R, Jia S, Zeng H, Wei Q, Tanguay RM, Wu T*. Association of polymorphisms of the heat shock protein 70 family genes with risk of acute high-altitude illness in a Chinese young population. Cell Stress and Chaperones, 2005,10(4): 349-356

25. Niu P, Niu Q, Zhang Q, Wang L, He S, Wu T, Conti P, Gioacchno M, Boscolo. Aluminum impairs rat neural cell mitochondria in vitro. Inter J Immunopathol Pharmacol, 2005,18(4):683-689

26. Wu T*, Tanguay RM. Presence of antibodies against heat shock proteins in environmental stresses and diseases: friend or foe? Cell Stress and Chaperones, 2006, 11(1):1-12

27. Niu P, Liu L, Gong Z, Tan H, Wang F, Yuan J, Feng Y, Wei Q, Tanguay RM, Wu T*. Over-expressed heat shock protein 70 protects cells against DNA damage caused by ultraviolet C in a dose-dependent manner. Cell Stress Chaperones, 2006, 11(2): 162-169

28. Hu Z, Shao M, Yuan J, Xu L, Wang F, Wang Y, Yuan W, Qian J, Ma H, Wang Y, Liu H, Chen W, Yang L, Jing G, Huo X, Chen F, Jin L, Wei Q, Huang W, Lu D, Wu T*, Shen H. Polymorphisms in DNA damage binding protein 2 (DDB2) and susceptibility of primary lung cancer in the Chinese: a case-control study. Carcinogenesis, 2006 27(7): 1475-1480

29. Liu AL, Lu WQ, Wang ZZ, Chen WH, Lu WH, Yuan J, Nan PH, Sun JY, Zou YL, Zhou LH, Zhang C and Wu T. Elevated levels of urinary 8-hydroxy-22- deoxyguanosine, lymphocytes micronucleus and serum glutathione S-transferase in workers exposed to coke oven emissions. Environ Health Perspect, 2006, 114(5): 673-677

30. Yang M, Tan H, Yuan J, Yang Q, Wang F, Yao H, Wei Q, Tanguay RM, Wu T*. Association of HSP70 gene polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers. Cell Stress Chaperones, 2006, 10(3): 233239

31. Chen Y, Bai Y, Yuan J, Chen W, Sun J, Wang H, Liang H, Gua L, Yang X, Tan H, Su Y, Wei Q, Wu T*. Association of polymorphisms in AhR, CYP1A1, GSTM1 and GSTT1 genes with levels of DNA damage in peripheral blood lymphocytes among coke-oven workers. Cancer Epidemiol Biomarkers Prev, 2006, 15(9):1703-1707

32. Gong Z, Yang J, Yang M, Wang F, Wei Q, Tanguay RM, Wu T*. Benzo(a)pyrene inhibits expression of inducible heat shock protein 70 in vascular endothelial cells. Toxicology Letter, 2006，166：229-236
33. Hu Z, Xu L, Shao M, Yuan J, Wang Y, Wang F, Yuan W, Qian J, Wang Y, Liu H, Chen W, Yang L, Jing G, Huo X, Chen F, Jin L, Wei Q, Wu T, Lu D, Huang W, Shen H. Polymorphisms in two helicases ERCC2/XPD and ERCC3/XPB of the transcription factor IIH complex and risk of lung cancer: a case-control analysis in Chinese population. Cancer Epidemiol Biomarkers Prev, 2006, 15(7): 1336-1340.

34. Ma H, Xu L, Yuan J, Shao M, Hu Z, Wang F, Wang Y, Yuan W, Qian J, Wang Y, Xun P, Liu H, Chen W, Yang L, Jin G, Huo X, Chen F, Yao Y, Jin L, Wei Q, Wu T, Shen H, Huang W, Lu D. Tagging single-nucleotide polymorphisms in excursion repair cross-complementing group1( ERCC1) and risk of primary lung cancer in a Chinese population. Phamacogenetics and Genetics, 2007 17(6): 417-423

35. He M, Cheng L, Jiang C, Zeng H, Wang J, Chen Y, Yang M, Zheng H, Hu FB, Wu T*. Associations of polymorphism of P22phox C242T, plasma levels of vitamin E, and smoking with coronary heart disease in China. Am J Heart. 2007, 163:640-646

36. Yang X, Yuan J, Sun J, Wang H, Liang H, Bai Y, Guo L, Tan H, Yang M, Wang J, Su Y, Chen W, Tanguay RM, Wu T. Association between heat-shock protein 70 gene polymorphisms and DNA damage in peripheral blood lymphocytes among coke-oven workers. Mut Res, 649: 221-229

37. Wang H, Chen W, Zhen H, Guo L, Liang H, Yang X, Bai Y, Tan H, Chen Y, Yuan J, Bi Y, Wei Q, Wu T*. Association between plasma BPDE-Alb adduct concentrations and DNA damage of peripheral blood lymphocytes among coke oven workers. Occup Environ Med, 2007, 64:753-758

38. Wang H, Liu A, Zheng H, Guo L, Liang H, Yang X, Bai Y, Chen, Wu T*. Relationship between plasma BPDE-albumin adducts and urinary 1hydroxypyrene among coke oven workers. Biomed Environ Sci，2007， 20:179-183

39. Bai Y, Xu L, Yuan J, Hu Z, Yang X, Wang F, Shao M, Wang Y, Yuan W, Qian J, Ma H, Wang Y, Liu H, Chen W, Yang L, Jing G, Huo X, Chen F, Liu Y, Jin L, Wei Q, Huang W, Shen H, Lu D, Wu T*. Single nucleotide polymorphisms of DNA repair gene XPC and risk of lung cancer in a Chinese population. BMC Cancer, 2007,7:81

40. Tan H, Xu Y, Xu J, Wang F, Nie S, Yang M, Yuan J, Tanguay RM, Wu T*. Association of increased heat shock protein 70 levels in the lymphocyte of early pregnant women with high risk of adverse pregnancy outcomes: a nested casecontrol study. Cell Stress Chaperones, 2007:12(3): 230-236

41. Yang M, Tan H, Cheng L, He M, Wei Q, Tanguay RM, Wu T*. Expression of heat shock proteins in myocardium of patients with atrial fibrillation. Cell Stress Chaperones, 2007,12:142-150

42. Yang X, Zheng J, Bai Y, Tian F, Yuan J, Sun J, Liang H, Guo L, Tan H, Chen W, Tanguay RM, Wu T*. Using lymphocytes and plasma Hsp70 as biomarkers for assessing coke oven exposure among steel workers. Environ Health Perspect 2007, 115:1573-77

43. Yang J, Liu X, Niu P, Zou Y, Gong Z, Yuan J, Wu T*. Dynamic changes of XPA, XPC, XPF, XPG and ERCC1 protein expression and their correlations with levels of DNA damage in human bronchial epithelia cells exposed to benzo[a]pyrene. Toxicology Letter, 2007, 174:10-17

44. Yang X, Yuan J, Sun J, Wang H, Liang H, Bai Y, Guo L, Tan H, Yang M, Wang J, Su Y, Chen W, Tanguay RM, Wu T*. Association between heat-shock protein 70 gene polymorphisms and DNA damage in peripheral blood lymphocytes among coke-oven workers. Mut Res Genet Toxicol Environ Mutag, 2008, 649:221-9

45. Shao M, Ma H, Wang Y, Xu L, Yuan J, Wang Y, Hu Z, Yang L, Wang F, Liu H, Qian J, Xun P, Chen W, Yuan W, Jing G, Chen F, Jin L, Wei Q, Wu T, Shen H, Huang W, Lu D. Polymorphisms in excision repair cross-complementing group 4 (ERCC4) and susceptibility to primary lung cancer in a Chinese Han population. Lung Cancer. 2008, 60:332-9

46. Zhang X, He M, Cheng L, Zhou L, Zeng H, Wang J, Wang F, Chen Y, Zhang L, Hu FB, Wu T*. Joint effects of antibody to heat shock protein 60 and hypertension, diabetes and risk of coronary heart disease in Chinese. Clin Chem ， 2008, 54:1046-1052

47. He M, Zhang X, Wang J, Cheng L, Zhou L, Zeng H, Wang F, Chen Y, Xu Z, Wei Q, Hu FB, Wu T*. Genetic variation in heat shock protein 60 gene and coronary heart disease in China: tagging-SNP haplotype analysis in a casecontrol study. Cell Stress Chaperones, 2008, 13(2): 231-238

48. Zou Y, Niu P, Yang J, Yuan J, Wu T, Chen X. The JNK signaling pathway is involved in sodium-selenite-induced apoptosis mediated by reactive oxygen in HepG2 cells. Cancer Biol Ther. 2008;7(5):689-696.

49. Zhang X, Wang H, Zhu X, Liu Y, Wang L, Dai Q, Cai N, Wu T, Chen W. Cohort mortality study in three ceramic factories in Jingdezhen in China. J Huazhong Univ Sci Technolog Med Sci. 2008; 28(4):386-390.

50. Yuan J, Chen L, Chen D, Guo H, Bi X, Ju Y, Jiang P, Shi J, Yu Z, Yang J, Li L, Jiang Q, Sheng G, Fu J, Wu T, Chen X. Elevated serum polybrominated diphenyl ethers and thyroid-stimulating hormone associated with lymphocytic micronuclei in Chinese workers from an E-waste dismantling site. Environ Sci Technol. 2008; 42(6):2195-2200.

51. Zhang X, He M, Cheng L, Chen Y, Zhou L, Zeng H, Pockley GA, Hu FB, Wu T*. Elevated heat shock protein 60 levels are associated with higher risk of coronary heart disease in Chinese. Circulation.2008, 118(25): 2687-2693.

52. Zhou L, Zhang X, He M, Cheng L, Chen Y, Hu FB, Wu T*. The Associations between single nucleotide polymorphisms on chromosome 9p21 and risk of coronary heart disease in Chinese Han population. Arterioscler Thromb Vasc Biol, 2008, 28(11): 2085-2089.

53. Wang F, Feng M, Xu P, Niu P, Yang X, Bai Y, Peng Y, Yao P, Tan H, Tanguay RM, Wu T. Hsp27 level in lymphocytes is negatively associated with a higher risk of lung cancer. Cell Stress Chaperones, 2009 14(3):245-251

54. He M, Guo H, Zhang X, Yang X, Zhou L, Cheng L, Zeng H, Hu FB, Tanguay RM, Wu T*. Genetic variants in hsp70-1 gene and risk of coronary heart disease. PLoS One 2009, e4851. http://dx.plos.org/10.1371/journal.pone.

55. Wu C, Hu Z, Yu D, Huang L, Jin G, Liang J, Guo H, Tan W, Zhang M, Qian J, Lu D, Wu T, Lin D, Shen H. Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations. Cancer Res. 2009;69(12):5065-72.

56. Ke Y, Zhang Z, Jiang Y, Zhuang Z, Li Y, Wu T*. Association of hOGG1 genotype with life style and oxidative DNA damage among Chinese ethnic populations. Arch Toxicol, 2009, DOI 10.1007/s00204-009-042-3.

57. Yang M, Guo H, He Y, Zhou L, Yu D, Tan W, Wang G, Wu C, Shen B, Yuan J, Wu T*, Lin D. Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk. Hum Mut, 2009 30:1-9

58. Shi XQ, Yang XB, Wang ZX, Qiu L, Wu T*, Wang ZZ. A novel use of neural network model to determine the effects of multi-biomarker on early health damage among Chinese steel workers. Environ Toxicol. 2011, 26: 1-9.

59. Wang F, He Y, Guo H, Li J, Yang Y, Wu Z, Zheng H, Wu T*. Genetic variants of nucleotide excision repair genes are associated with DNA damage in coke oven workers. Cancer Epidemiol Biomarkers Prev, 2010, 19(1): 211-218.

60. Zhang X, Xu Z, Chen Y, He M, Cheng L, Zhou L, Zeng H, Hu FB, Tanguay RM, Wu T*. Plasma levels of Hsp70 and anti-Hsp70 antibody predict risk of coronary heart disease. Cell Stress Chaperones, 2010, 15(5):675-86

61. Guo H, Bai Y, Xu P, Hu Z, Liu L, Wang F, Jin G, Wang F, Deng Q, Tu Y, Feng M, Lu D, Shen H, Wu T*. Functional promoter -1271G>C variant of HSPB1 predicts lung cancer risk and survival. J Clin Oncol. 2010; 28(11): 1928-1935

62. Hsiung CA, Lan Q, Hong YC, Chen CJ, Hosgood HD, Chang IS, Chatterjee N, Brennan P, Wu C, Zheng W, Chang GC, Wu T, Park JY, Hsiao CF, Kim YH, Shen H, Seow A, Yeager M, Tsai YH, Kim YT, Chow WH, Guo H, Wang WC, Sung SW, Hu Z, Chen KY, Kim JH, Chen Y, Huang L, Lee KM, Lo YL, Gao YT, Kim JH, Liu L, Huang MS, Jung TH, Jin G, Caporaso N, Yu D, Kim CH, Su WC, Shu XO, Xu P, Kim IS, Chen YM, Ma H, Shen M, Cha SI, Tan W, Chang CH, Sung JS, Zhang M, Yang TY, Park KH, Yuenger J, Wang CL, Ryu JS, Xiang Y, Deng Q, Hutchinson A, Kim JS, Cai Q, Landi MT, Yu CJ, Park JY, Tucker M, Hung JY, Lin CC, Perng RP, Boffetta P, Chen CY, Chen KC, Yang SY, Hu CY, Chang CK, Fraumeni JF Jr, Chanock S, Yang PC, Rothman N, Lin D. The 5p15.33 locus is associated with risk of lung adenocarcinoma in neversmoking females in Asia. Plos Genet, 2010,6(8): e1001051

63. He M, Guo H, Yang X, Zhou L, Zhang X, Cheng L, Zeng H, Hu F, Tanguay RM, Wu T*. Genetic variations in HSPA8 gene associated with coronary heart disease risk in a Chinese population. PLoS One, 2010, E-9654

64. Wu C, Xu B, Yuan P, Miao X, Liu Y, Guan Y, Yu D, Xu J, Zhang T, Shen H, Wu T*, Lin D. Genome-wide interrogation identifies YAP1 variants associated with survival of small-cell lung cancer patients. Cancer Res. 2010; 70(23):97219729

65. Wu C, Hu Z, He Z, Jia W, Wang F, Zhou Y, Liu Z, Zhan Q, Liu Y, Yu D, Zhai K, Chang J, Qiao Y, Jin G, Liu Z, Shen Y, Guo C, Fu J, Miao X, Tan W, Shen H, Ke Y, Zeng Y, Wu T, Lin D. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nat Genet. 2011;43(7):679-84.

66. Liu L, Wu C, Wang Y, Zhong R, Wang F, Zhang X, Duan S, Lou J, Yu D, Tan W, Yuan J, Wu T, Nie S, Miao X, Lin D. Association of candidate genetic variations with gastric cardia adenocarcinoma in Chinese population: a multiple interaction analysis. Carcinogenesis. 2011; 32(3):336-432.

67. Liu L, Yuan P, Wu C, Zhang X, Wang F, Guo H, Zhong R, Xu Y, Wu J, Yu D, Wu T, Zhang X, Nie S, Miao X, Lin D. Assessment of XPD Lys751Gln and XRCC1 T-77C polymorphisms in advanced non-small-cell lung cancer patients treated with platinum-based chemotherapy. Lung Cancer. 2011; 73(1):110-115.

68. Xu Z, Ren T, Xiao C, Li H, Wu T. Nickel promotes the invasive potential of human lung cancer cells via TLR4/MyD88 signaling.Toxicology. 2011 11; 285(1-2):25-30.

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161. Feng W, Huang X, Zhang C, Liu C, Cui X, Zhou Y, Sun H, Qiu G, Guo H, He M, Zhang X, Yuan J, Chen W, Wu T*. The dose-response association of urinary metals with altered pulmonary function and risks of restrictive and obstructive lung diseases: a population-based study in China. BMJ Open. 2015 May 21;5(5):e007643. doi: 10.1136/bmjopen-2015-007643.

162. Feng W, Cui X, Liu B, Liu C, Xiao Y, Lu W, Guo H, He M, Zhang X, Yuan J, Chen W, Wu T*. Association of urinary metal profiles with altered glucose levels and diabetes risk: a population-based study in China. PLoS One. 2015 Apr 13;10(4):e0123742. doi: 10.1371/journal.pone.0123742. eCollection 2015.

163. Machiela MJ, Zhou W, Sampson JN, Dean MC, Jacobs KB, Black A, Brinton LA, Chang IS, Chen C, Chen C, Chen K, Cook LS, Crous Bou M, De Vivo I, Doherty J, Friedenreich CM, Gaudet MM, Haiman CA, Hankinson SE, Hartge P, Henderson BE, Hong YC, Hosgood HD 3rd, Hsiung CA, Hu W, Hunter DJ, Jessop L, Kim HN, Kim YH, Kim YT, Klein R, Kraft P, Lan Q, Lin D, Liu J, Le Marchand L, Liang X, Lissowska J, Lu L, Magliocco AM, Matsuo K, Olson SH, Orlow I, Park JY, Pooler L, Prescott J, Rastogi R, Risch HA, Schumacher F, Seow A, Setiawan VW, Shen H, Sheng X, Shin MH, Shu XO, VanDen Berg D, Wang JC, Wentzensen N, Wong MP, Wu C, Wu T, Wu YL, Xia L, Yang HP, Yang PC, Zheng W, Zhou B, Abnet CC, Albanes D, Aldrich MC, Amos C, Amundadottir LT, Berndt SI, Blot WJ, Bock CH, Bracci PM, Burdett L, Buring JE, Butler MA, Carreón T, Chatterjee N, Chung CC, Cook MB, Cullen M, Davis FG, Ding T, Duell EJ, Epstein CG, Fan JH, Figueroa JD, Fraumeni JF Jr, Freedman ND, Fuchs CS, Gao YT, Gapstur SM, Patiño-Garcia A, Garcia-Closas M, Gaziano JM, Giles GG, Gillanders EM, Giovannucci EL, Goldin L, Goldstein AM, Greene MH, Hallmans G, Harris CC, Henriksson R, Holly EA, Hoover RN, Hu N, Hutchinson A, Jenab M, Johansen C, Khaw KT, Koh WP, Kolonel LN, Kooperberg C, Krogh V, Kurtz RC, LaCroix A, Landgren A, Landi MT, Li D, Liao LM, Malats N, McGlynn KA, McNeill LH, McWilliams RR, Melin BS, Mirabello L, Peplonska B, Peters U, Petersen GM, Prokunina-Olsson L, Purdue M, Qiao YL, Rabe KG, Rajaraman P, Real FX, Riboli E, Rodríguez-Santiago B, Rothman N, Ruder AM, Savage SA, Schwartz AG, Schwartz KL, Sesso HD, Severi G, Silverman DT, Spitz MR, Stevens VL, Stolzenberg-Solomon R, Stram D, Tang ZZ, Taylor PR, Teras LR, Tobias GS, Viswanathan K, Wacholder S, Wang Z, Weinstein SJ, Wheeler W, White E, Wiencke JK, Wolpin BM, Wu X, Wunder JS, Yu K, Zanetti KA, Zeleniuch-Jacquotte A, Ziegler RG, de Andrade M, Barnes KC, Beaty TH, Bierut LJ, Desch KC, Doheny KF, Feenstra B, Ginsburg D, Heit JA, Kang JH, Laurie CA, Li JZ, Lowe WL, Marazita ML, Melbye M, Mirel DB, Murray JC, Nelson SC, Pasquale LR, Rice K, Wiggs JL, Wise A, Tucker M, Pérez-Jurado LA, Laurie CC, Caporaso NE, Yeager M, Chanock SJ. Characterization of large structural genetic mosaicism in human autosomes. Am J Hum Genet. 2015;96(3):487-97.

164. Huang S, Lv Z, Deng Q, Li L, Yang B, Feng J, Wu T, Zhang X, Cheng J. A genetic variant in pre-miR-146a (rs2910164 C>G) is associated with the decreased risk of acute coronary syndrome in a Chinese population. Tohoku J Exp Med. 2015;237(3):227-33. doi: 10.1620/tjem.237.227.

165. Sampson JN, Wheeler WA, Yeager M, Panagiotou O, Wang Z, Berndt SI, Lan Q, Abnet CC, Amundadottir LT, Figueroa JD, Landi MT, Mirabello L, Savage SA, Taylor PR, Vivo ID, McGlynn KA, Purdue MP, Rajaraman P, Adami HO, Ahlbom A, Albanes D, Amary MF, An SJ, Andersson U, Andriole G Jr, Andrulis IL, Angelucci E, Ansell SM, Arici C, Armstrong BK, Arslan AA, Austin MA, Baris D, Barkauskas DA, Bassig BA, Becker N, Benavente Y, Benhamou S, Berg C, Van Den Berg D, Bernstein L, Bertrand KA, Birmann BM, Black A, Boeing H, Boffetta P, Boutron-Ruault MC, Bracci PM, Brinton L, Brooks-Wilson AR, Bueno-de-Mesquita HB, Burdett L, Buring J, Butler MA, Cai Q, Cancel-Tassin G, Canzian F, Carrato A, Carreon T, Carta A, Chan JK, Chang ET, Chang GC, Chang IS, Chang J, Chang-Claude J, Chen CJ, Chen CY, Chen C, Chen CH, Chen C, Chen H, Chen K, Chen KY, Chen KC, Chen Y, Chen YH, Chen YS, Chen YM, Chien LH, Chirlaque MD, Choi JE, Choi YY, Chow WH, Chung CC, Clavel J, ClavelChapelon F, Cocco P, Colt JS, Comperat E, Conde L, Connors JM, Conti D, Cortessis VK, Cotterchio M, Cozen W, Crouch S, Crous-Bou M, Cussenot O, Davis FG, Ding T, Diver WR, Dorronsoro M, Dossus L, Duell EJ, Ennas MG, Erickson RL, Feychting M, Flanagan AM, Foretova L, Fraumeni JF Jr, Freedman ND, Beane Freeman LE, Fuchs C, Gago-Dominguez M, Gallinger S, Gao YT, Gapstur SM, Garcia-Closas M, GarcíaClosas R, Gascoyne RD, Gastier-Foster J, Gaudet MM, Gaziano JM, Giffen C, Giles GG, Giovannucci E, Glimelius B, Goggins M, Gokgoz N, Goldstein AM, Gorlick R, Gross M, Grubb R 3rd, Gu J, Guan P, Gunter M, Guo H, Habermann TM, Haiman CA, Halai D, Hallmans G, Hassan M, Hattinger C, He Q, He X, Helzlsouer K, Henderson B, Henriksson R, Hjalgrim H, Hoffman-Bolton J, Hohensee C, Holford TR, Holly EA, Hong YC, Hoover RN, Horn-Ross PL, Hosain GM, Hosgood HD 3rd, Hsiao CF, Hu N, Hu W, Hu Z, Huang MS, Huerta JM, Hung JY, Hutchinson A, Inskip PD, Jackson RD, Jacobs EJ, Jenab M, Jeon HS, Ji BT, Jin G, Jin L, Johansen C, Johnson A, Jung YJ, Kaaks R, Kamineni A, Kane E, Kang CH, Karagas MR, Kelly RS, Khaw KT, Kim C, Kim HN, Kim JH, Kim JS, Kim YH, Kim YT, Kim YC, Kitahara CM, Klein AP, Klein RJ, Kogevinas M, Kohno T, Kolonel LN, Kooperberg C, Kricker A, Krogh V, Kunitoh H, Kurtz RC, Kweon SS, LaCroix A, Lawrence C, Lecanda F, Lee VH, Li D, Li H, Li J, Li YJ, Li Y, Liao LM, Liebow M, Lightfoot T, Lim WY, Lin CC, Lin D, Lindstrom S, Linet MS, Link BK, Liu C, Liu J, Liu L, Ljungberg B, Lloreta J, Lollo SD, Lu D, Lund E, Malats N, Mannisto S, Marchand LL, Marina N, Masala G, Mastrangelo G, Matsuo K, Maynadie M, McKay J, McKean-Cowdin R, Melbye M, Melin BS, Michaud DS, Mitsudomi T, Monnereau A, Montalvan R, Moore LE, Mortensen LM, Nieters A, North KE, Novak AJ, Oberg AL, Offit K, Oh IJ, Olson SH, Palli D, Pao W, Park IK, Park JY, Park KH, Patiño-Garcia A, Pavanello S, Peeters PH, Perng RP, Peters U, Petersen GM, Picci P, Pike MC, Porru S, Prescott J, Prokunina-Olsson L, Qian B, Qiao YL, Rais M, Riboli E, Riby J, Risch HA, Rizzato C, Rodabough R, Roman E, Roupret M, Ruder AM, Sanjose Sd, Scelo G, Schned A, Schumacher F, Schwartz K, Schwenn M, Scotlandi K, Seow A, Serra C, Serra M, Sesso HD, Setiawan VW, Severi G, Severson RK, Shanafelt TD, Shen H, Shen W, Shin MH, Shiraishi K, Shu XO, Siddiq A, Sierrasesúmaga L, Sihoe AD, Skibola CF, Smith A, Smith MT, Southey MC, Spinelli JJ, Staines A, Stampfer M, Stern MC, Stevens VL, Stolzenberg-Solomon RS, Su J, Su WC, Sund M, Sung JS, Sung SW, Tan W, Tang W, Tardón A, Thomas D, Thompson CA, Tinker LF, Tirabosco R, Tjønneland A, Travis RC, Trichopoulos D, Tsai FY, Tsai YH, Tucker M, Turner J, Vajdic CM, Vermeulen RC, Villano DJ, Vineis P, Virtamo J, Visvanathan K, Wactawski-Wende J, Wang C, Wang CL, Wang JC, Wang J, Wei F, Weiderpass E, Weiner GJ, Weinstein S, Wentzensen N, White E, Witzig TE, Wolpin BM, Wong MP, Wu C, Wu G, Wu J, Wu T, Wu W, Wu X, Wu YL, Wunder JS, Xiang YB, Xu J, Xu P, Yang PC, Yang TY, Ye Y, Yin Z, Yokota J, Yoon HI, Yu CJ, Yu H, Yu K, Yuan JM, Zelenetz A, Zeleniuch-Jacquotte A, Zhang XC, Zhang Y, Zhao X, Zhao Z, Zheng H, Zheng T, Zheng W, Zhou B, Zhu M, Zucca M, Boca SM, Cerhan JR, Ferri GM, Hartge P, Hsiung CA, Magnani C, Miligi L, Morton LM, Smedby KE, Teras LR, Vijai J, Wang SS, Brennan P, Caporaso NE, Hunter DJ, Kraft P, Rothman N, Silverman DT, Slager SL, Chanock SJ, Chatterjee N. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types. J Natl Cancer Inst. 2015;107(12):djv279. doi: 10.1093/jnci/djv279.

166. Wen Q, Wu F, Yang J, Wu J, Zhang X, He M, Wu T, Cheng L. A single-nucleotide polymorphism in the interleukin-1 receptor-associated protein gene is associated with impaired glucose regulation and type 2 diabetes in a case-controlled study. Biomed Rep. 2015;3(4):549-553.

167. Bai Y, Feng W, Wang S, Zhang X, Zhang W, He M, Zhang X, Wu T, Guo H. Essential Metals Zinc, Selenium, and Strontium Protect against Chromosome Damage Caused by Polycyclic Aromatic Hydrocarbons Exposure. Environ Sci Technol. 2016 Jan 19;50(2):951-60. doi: 10.1021/acs.est.5b03945. Epub 2016 Jan 5.

168. Lv Z, Cheng J, Huang S, Zhang Y, Wu S, Qiu Y, Geng Y, Zhang Q, Huang G, Ma Q, Xie X, Zhou S, Wu T, Ke Y. DEHP induces obesity and hypothyroidism through both central and peripheral pathways in C3H/He mice. Obesity (Silver Spring). 2015 Dec 10. doi: 10.1002/oby.21359. [Epub ahead of print]

169. Zhou Y, Sun H, Xie J, Song Y, Liu Y, Huang X, Zhou T, Rong Y, Wu T, Yuan J, Chen W. Urinary polycyclic aromatic hydrocarbon metabolites and altered lung function in Wuhan, China. Am J Respir Crit Care Med. 2015 Dec 4. [Epub ahead of print]

170. Yang L, Yang H, He M, Pan A, Li X, Min X, Zhang C, Xu C, Zhu X, Yuan J, Wei S, Miao X, Hu FB, Wu T, Zhang X. Longer sleep duration and midday napping are associated with a higher risk of CHD incidence in middle-aged and older Chinese: the Dongfeng-Tongji cohort study. Sleep. 2015 Nov 6. pii: sp-00311-15.

171. Liu J, Zhu M, Chen W, Xie K, Shen W, Yuan J, Cheng Y, Geng L, Wang Y, Jin G, Dai J, Ma H, Du J, Wang M, Zhang Z, Hu Z, Wu T, Shen H. Genetic variants in multisynthetase complex genes are associated with DNA damage levels in Chinese populations.Mutat Res. 2016 Jan 25;786:8-13. doi: 10.1016/j.mrfmmm.2016.01.006. [Epub ahead of print]

172. Li L, Chen J, Chen X, Tang J, Guo H, Wang X, Qian J, Luo G, He F, Lu X, Ding Y, Yang Y, Huang W, Hou G, Lin X, Ouyang Q, Li H, Wang R, Jiang F, Pu R, Lu J, Jin M, Tan Y, Gonzalez FJ, Cao G, Wu M, Wen H, Wu T, Jin L, Chen L, Wang H. Serum miRNAs as predictive and preventive biomarker for pre-clinical hepatocellular carcinoma.Cancer Lett. 2016 Feb 2. pii: S0304-3835(16)00040-9. doi: 10.1016/j.canlet.2016.01.028. [Epub ahead of print]

173. Qian L, Tanguay RM, Wu T, Hightower LE. Stress and health Huangshan-style. Cell Stress Chaperones. 2016 Feb 4. [Epub ahead of print]

174. Wen W, Kato N, Hwang JY, Guo X, Tabara Y, Li H, Dorajoo R, Yang X, Tsai FJ, Li S, Wu Y, Wu T, Kim S, Guo X, Liang J, Shungin D, Adair LS, Akiyama K, Allison M, Cai Q, Chang LC, Chen CH, Chen YT, Cho YS, Choi BY, Gao Y, Go MJ, Gu D, Han BG, He M, Hixson JE, Hu Y, Huang T, Isono M, Jung KJ, Kang D, Kim YJ, Kita Y, Lee J, Lee NR, Lee J, Wang Y, Liu JJ, Long J, Moon S, Nakamura Y, Nakatochi M, Ohnaka K, Rao D, Shi J, Sull JW, Tan A, Ueshima H, Wu C, Xiang YB, Yamamoto K, Yao J, Ye X, Yokota M, Zhang X, Zheng Y, Qi L, Rotter JI, Jee SH, Lin D, Mohlke KL, He J, Mo Z, Wu JY, Tai ES, Lin X, Miki T, Kim BJ, Takeuchi F, Zheng W, Shu XO. Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. Sci Rep. 2016 Jan 20;6:17958. doi: 10.1038/srep17958.

175. Wen W, Lu L, He Y, Cheng H, He F, Cao S, Li L, Xiong L, Wu T*. LincRNAs and base modifications of p53 induced by arsenic methylation in workers. Chem Biol Interact. 2016 Feb 25;246:1-10. doi: 10.1016/j.cbi.2016.01.003. Epub 2016 Jan 6.

176. Yang B, Deng Q, Zhang W, Feng Y, Dai X, Feng W, He X, Huang S, Zhang X, Li X, Lin D, He M, Guo H, Sun H, Yuan J, Lu J, Hu FB, Zhang X, Wu T*. Exposure to Polycyclic aromatic hydrocarbons, plasma cytokines, and heart rate variability. Sci Rep. 2016 Jan 13;6:19272. doi: 10.1038/srep19272.

177. Zhu X, Li J, Deng S, Yu K, Liu X, Deng Q, Sun H, Zhang X, He M, Guo H, Chen W, Yuan J, Zhang B, Kuang D, He X, Bai Y, Han X, Liu B, Li X, Yang L, Jiang H, Zhang Y, Hu J, Cheng L, Luo X, Mei W, Zhou Z, Sun S, Zhang L, Liu C, Guo Y, Zhang Z, Hu FB, Liang L, Wu T*. Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in Chinese. Environ Health Perspect. 2016 Jan 12. [Epub ahead of print]

178. Wang Z, Seow WJ, Shiraishi K, Hsiung CA, Matsuo K, Liu J, Chen K, Yamji T, Yang Y, Chang IS, Wu C, Hong YC, Burdett L, Wyatt K, Chung CC, Li SA, Yeager M, Hutchinson A, Hu W, Caporaso N, Landi MT, Chatterjee N, Song M, Fraumeni JF Jr, Kohno T, Yokota J, Kunitoh H, Ashikawa K, Momozawa Y, Daigo Y, Mitsudomi T, Yatabe Y, Hida T, Hu Z, Dai J, Ma H, Jin G, Song B, Wang Z, Cheng S, Yin Z, Li X, Ren Y, Guan P, Chang J, Tan W, Chen CJ, Chang GC, Tsai YH, Su WC, Chen KY, Huang MS, Chen YM, Zheng H, Li H, Cui P, Guo H, Xu P, Liu L, Iwasaki M, Shimazu T, Tsugane S, Zhu J, Jiang G, Fei K, Park JY, Kim YH, Sung JS, Park KH, Kim YT, Jung YJ, Kang CH, Park IK, Kim HN, Jeon HS, Choi JE, Choi YY, Kim JH, Oh IJ, Kim YC, Sung SW, Kim JS, Yoon HI, Kweon SS, Shin MH, Seow A, Chen Y, Lim WY, Liu J, Wong MP, Lee VH, Bassig BA, Tucker M, Berndt SI, Chow WH, Ji BT, Wang J, Xu J, Sihoe AD, Ho JC, Chan JK, Wang JC, Lu D, Zhao X, Zhao Z, Wu J, Chen H, Jin L, Wei F, Wu G, An SJ, Zhang XC, Su J, Wu YL, Gao YT, Xiang YB, He X, Li J, Zheng W, Shu XO, Cai Q, Klein R, Pao W, Lawrence C, Hosgood HD 3rd, Hsiao CF, Chien LH, Chen YH, Chen CH, Wang WC, Chen CY, Wang CL, Yu CJ, Chen HL, Su YC, Tsai FY, Chen YS, Li YJ, Yang TY, Lin CC, Yang PC, Wu T, Lin D, Zhou B, Yu J, Shen H, Kubo M, Chanock SJ, Rothman N, Lan Q. Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. Hum Mol Genet. 2016 Jan 4. pii: ddv494. [Epub ahead of print]

179. Huang S, Deng Q, Feng J, Zhang X, Dai X, Li L, Yang B, Wu T, Cheng J. Polycyclic aromatic hydrocarbons-associated microRNAs and heart rate variability in coke oven workers. J Occup Environ Med. 2016 Jan;58(1):e24-31. doi: 10.1097/JOM.0000000000000564.

English Books

1. Tanguay RM and Wu T. Heat Shock Proteins in Environmental Stresses and Environment-related Diseases. In: Radons J, Muelthoff G (Eds), Heat Shock proteins in biology and medicine. 2006. pp 407-420, Research Signpost.

2. Guo H, Wu T. Small HSP variants and human diseases P383-397. in Tanguay RM and Hightower LE, The Big Book on Small Heat Shock Proteins. Spring, 2015

iii- Abstracts and Presentations( in English)

1. Wu T, Sheng Chen, Chengfeng Xiao, Yang Wu, Hanzhen He, Guogao Zhang, and Robert M.Tanguay. Heat shock proteins and their antibodies as biomarkers of abnormal xenobiotic-induced stress within the working environment. 2nd International Workshop on Molecular Biology of Stress Responses. October 15-18, 1999; Wuhan, China (Invited speaker and Chairman)

2. Sheng Chen, Wu T, Hai Tao, Pan Qiuping, Xiao Chengfeng, He Hanzhen. Was HSP70 involved in the protection of lymphocytes from genotoxic damage induced by occupational hazards? a survey in coke oven workers. 2nd International Workshop on Molecular Biology of Stress Responses. October 15-18, 1999; Wuhan, China

3. Xiao Chengfeng, Chen Sheng, Gao Yajuan, Wang Ruibo, He Hanzhen, Wu T. Role of HSP71 in apoptosis of human hepatocyte L-02 induced by etoposide. 2nd International Workshop on Molecular Biology of Stress Responses. October 15-18, 1999; Wuhan, China

4. Xu Yun, Sheng Chen. Xu Yong, Yang ChunXiu, Wu T. Study on the role of plasma heat stress proteins and its antibody in benzene toxin. 2nd International Workshop on Molecular Biology of Stress Responses. October 15-18, 1999; Wuhan, China

5. Fang Jun-ming, Wu T, Yu Li, Zhang Yun-xing, Fang Xue-yun, He Xiao-sheng, He Han-zheng . Study on the Levels of Heat Stress Proteins, p53 and ras Oncogene Protein in CSF from Children Patients with Leukemia as well as their Clinical Effect. 2nd International Workshop on Molecular Biology of Stress Responses. October 15-18, 1999; Wuhan, China

6. Liu Bing, Wu T, Wu ZhiHao, Sheng Chen, Xu Wen, Zhang XueLin. Plasma Heat Shock Protein 70 in Soldiers Marching for Different Time in Desert at Different Speed with or without Load in Desert. 2nd International Workshop on Molecular Biology of Stress Responses. October 15-18, 1999; Wuhan, China

7. Liu Bing, Sheng Chen, Xu Wen, Wu T, Wu ZhiHao, Zhang XueLing, Wu ZhiHao. Plasma Heat Shock Protein 27 in Soldiers Marching for Different Time at Different Speed with or without Load in Desert. 2nd International Workshop on Molecular Biology of Stress Responses. October 15-18, 1999; Wuhan, China

8. Sun Yehuan , Wu T , Ma Jinxiang. Antibodies to the 70-kD heat shock protein in normotensive and hypertensive humans. 2nd International Workshop on Molecular Biology of Stress Responses. October 15-18, 1999; Wuhan, China

9. Ma Jinxiang , Wu T , Sun Yehuan, Cao Duozhi . Presence of antibodies to the 70kD heat shock protein in integrated iron and steel workers exposed to abnormal stress in working environment. 2nd International Workshop on Molecular Biology of Stress Responses. October 15-18, 1999; Wuhan, China

10. Wang Zizheng, Wang changlai, Sheng Chen, Wu T, Mao Zhicheng . The study of relationship between the Heat Stress Protein 70 (HSP70) and cytokines in patients with heat apoplexy. 2nd International Workshop on Molecular Biology of Stress Responses. October 15-18, 1999; Wuhan, China

11. Wang Xiuling, Wu T, Sheng Chen, Zhou Tong, Jin Xipeng. The Measurement of Antibodies to HSP70 and HSP70 in Plasma of Workers Exposed to Xylene and Toluene. 2nd International Workshop on Molecular Biology of Stress Responses. October 15-18, 1999; Wuhan, China

12. Yajuan Gao, Wu T, Sheng Chen, Chengfeng Xiao, Hanzhen He. Correlation of Hsp70 and p53 expression, DNA damage in HEL cells induced by benzo(a)pyrene and high temperature. II International Conference on Heat Shock proteins in Immune Response. Farmington, Connecticut, USA, 2000,Oct 8-12: Cell Stress & Chaperones, 2000, 5(4): 386(Invited speaker)

13. Wu T, Sheng Chen, Chengfeng Xiao, Changlai Wang, Qin Pan, Zizheng Wang, Meiyun Xie, Zhicheng Mao, Yang Wu and Robert Tanguay. Presence of antibody against the inducible heat shock protein Hsp71 in patients with acute heat induced illness. II International Conference on Heat Shock proteins in Immune Response. Farmington, Connecticut, USA, 2000, Oct 8-12: Cell Stress & Chaperones,2000, 5(4): 397

14. Wu T, Sheng Chen, Chengfeng Xiao, Yajuan Gao, Ruibo Wang, Robert M. Tanguay. Association of inducible Hsp71 and its antibodies with environmental stresses and disease. 3rd International Workshop on Molecular Biology of Stress Responses. October 10-13, 2001, Mendoza, Argentina. (Invited speaker)

15. Wu T, S. Chen, C. Xiao, C. Wang, Q. Pan, Z. Wang, M. Xie, Z. Mao, Y. Wu and R. M. Tanguay. Presence of antibody against the inducible heat shock protein hsp71 in patients with acute heat induced illness. International Thermal Physiology Symposium, Wollongong, Australia, September 2nd-6th.

16. Wu T, S. Chen, C.Xiao, Y. Wu, H. He, G. Zhang, R M.Tanguay. Study on the possibility of antibodies against Hsps as biomarkers to assess abnormal stress. International Thermal Physiology Symposium (official IUPS satellite meeting). Wollongong, Australia, September 2nd-6th. (Invited speaker)

17. C. Xiao, Wu T , S. Chen, Q. Pan, Z. Wang, M. Xie, Z. Mao. Basal and inducible level of hsp71 in peripheral lymphocytes in soldier with heat induced illness. International Thermal Physiology Symposium (official IUPS satellite meeting), Wollongong, Australia, September 2nd-6th, 2001.

18. Gao Y, Chen S, Xiao C, Wang R, He H, Tanguay RM, Wu T. In vitro study on the role of Hsp70 expression in DNA damage in human embryonic lung cells exposed to benzo(a)pyrene. 11th North American ISSX Meeting, Miami, USA, Oct 27-31, 2002. No: 51(Oral Presentation). Drug Metab Rev, 2002,34 (supple 1):26

19. Xiao C, Chen S,Gao Y, He H and Wu T. Role of Hsp70 in protection of human hepatocyte L-02 against DNA damage & apoptosis caused by etoposide. 11th North American ISSX Meeting, Miami, USA, Oct 27-31, 2002. No: 198. Drug Metab Rev, 2002,34(supple 1):99
20. Xiao C, Chen S, Li J, Hai T, Tanguay RM, Wu T. Association of HSP70 and genotoxic damage in lymphocytes of workers exposed to coke-oven emission.11th North American ISSX Meeting, Miami, USA, Oct 27-31, 2002. No: 199. Drug Metab Rev, 2002,34(supple 1):100

21. Wu T, Tanguay RM. The difference in presence of autoantibodies against Hsps and their significance in environmental stresses and diseases. 1st International Congress on Stress Response in Biology and Medicine. Quebec, Canada, Sep1014th, 2003. P71. (Invited speaker and Chairman)

22. Xie J, Xu Y, Yang M, Zhang Z, Wang F, Chen S, Tanguay RM, Wu T. Presence of plasma antibodies against Hsp60 and Hsp70 in Patients with asthma. 1st International Congress on Stress Response in Biology and Medicine. Quebec, Canada, Sep10-14th, 2003. P135 (Poster)

23. Jin X, Xiao C, Tanguay RM, Yang L, Wang F, Chen M, Fu X, Wang R, Deng J, Deng J, Zheng Y, Wei Q, Wu T. Dynamic changes of antibody against Hsp70 in elder patients with cerebral infarction. 1st International Congress on Stress Response in Biology and Medicine. Quebec, Canada, Sep10-14th,2003. P134 (Poster)

24. Li F, Zhou F, Xiao C, Sun S, Wang F, Zhang S, Liao R, Jia S, Zhen H, Tanguay RM, Wu T. Association of Hsp70 polymorphism with susceptibility of stress response to low oxygen in human. 1st International Congress on Stress Response in Biology and Medicine. Quebec, Canada, Sep10-14th, 2003. P135 (Poster).

25. Yang M, Tan H, Jiang C, Cheng L, Dai Y, Wang X, He M, Wang F, Chen Y, Tanguay RM, Wei Q, Wu T*. The expression of heat shock protein 72 and 73 in myocardium of patients with atrial fibrillation. 4th International Workshop on the Molecular Biology of Stress Responses, 2004, May13-16, Wuhan and Yichang. (Invited speaker and Chairman)

26. Jin X, Xiao C, Yang L, Wang F, Chen M, Fu X, Wang R, Deng J, Deng Z, Chen S, Tanguay RM, Wu T*. Dynamic changes of antibody against Hsp70 in the elder patients with cerebral infarction. 4th International Workshop on the Molecular Biology of Stress Responses, 2004, May13-16, Wuhan and Yichang. (Poster)

27. Yang J, Yang M, Tan H, Wang F, Chen Y, Jiang C, He M, Wei Q, Tanguay RM, Hu FB and Wu T*. Possible mechanism of inhibited expression of inducible heat shock protein 70 by Benzo(a)pyrene in vascular endothelial cells. 4th International Workshop on the Molecular Biology of Stress Responses, 2004, May13-16, Wuhan and Yichang.

28. Ke L, Xiao C, Yang J, Yang M, Tan H, Wang F, Jiang C, He M, Duan Y, He H, Chen G, Wu T*. Different expressions of the Hsp70 family of A549 cells treated with the combination of heat and benzo(a)pyrene. 4th International Workshop on the Molecular Biology of Stress Responses, 2004, May13-16, Wuhan and Yichang. (Oral)

29. Yang M, Zheng J, Tan H, Yang Q, Wang F, Yao H, Chen Y, Jiang C, He M, Chen S, Wei Q, Tanguay RM and Wu T*. Polymorphism of heat-shock protein gene HSP70-hom in workers with noise-induced hearing loss. 4th International Workshop on the Molecular Biology of Stress Responses, 2004, May13-16, Wuhan and Yichang. (Oral)

30. Yuan J, Yang M, Yao H, Zheng J, Yang Q, Chen S, Wei Q, Tanguay RM, Wu T*. Association of plasma antibodies against Hsps 60 and 70 with cumulative noise exposure and cardiac function abnormity in Chinese automobile workers. 4th International Workshop on the Molecular Biology of Stress Responses, 2004, May13-16, Wuhan and Yichang. (Poster)

31. Xu Z, Yang J, Xu Q, Bai Y, Hu B, Wu T*. Vitamin E and C reduce the inhibition of Hsp70 expression in endothelial cells exposed to BaP. 7th International ISSX Meeting, Vancouver, Canada, Aug 29- Sep 2, 2004. No: 442. Drug Metab Rev, 2004, 36(Supple 1): 220 (SCI, IF=5.4) (Poster)

32. Yang J, Wei Q, Tanguay RM, Hu B, Wu T*. Benzo(a)pyrene inhibits expression of inducible heat shock protein 70 through inhibition of heat shock factor1 and its binding to heat shock element in vascular endothelial cells. 7th International ISSX Meeting, Vancouver, Canada, Aug 29- Sep 2, 2004. No: 276. Drug Metab Rev, 2004, 36(Supple 1): 138 (SCI, IF=5.4) (Poster)

33. Liu G, Shi N,Wu T. Effects of deltamethrin on tyrosine hydroxylase in the nigrostriatum of male rats. 7th International ISSX Meeting, Vancouver, Canada, Aug 29- Sep 2, 2004. No: 538. Drug Metab Rev, 2004, 36(Supple 1): 269 (SCI, IF=5.4) (Poster)

34. Yang J, He Q, Xu Q, Wang F, Ke L, Hu B, Wu T*. Role of protein kinase C and mitogen activated protein kinase in Hsp70 expression caused by Benzo(a)pyrene. 7th International ISSX Meeting, Vancouver, Canada, Aug 29- Sep 2, 2004. No: 277. Drug Metab Rev, 2004, 36(Supple 1): 138 (SCI, IF=5.4) (Poster)

35. He M, Jiang C, Zeng H, Cheng L, Wang F, Yang M, Tan H, Yang X, Bai Y, Long Z, Zheng H, Hu FB, Wu T*. Associations of polymorphism of P22phox C242T and plasma levels of vitamin E with coronary heart disease in China. 7th International ISSX Meeting, Vancouver, Canada, Aug 29- Sep 2, 2004. No: 221. Drug Metab Rev, 2004, 36(Supple 1): 110(SCI, IF=5.4) (Poster)

36. Wu T. The presence and significance of heat shock proteins and their antibodies in occupational stresses and diseases, 16th China-Korea-Japan Joint Conference on Occupational Health, June 2-4, 2005, Dalian, China ( Keynote Speech)

37. Wu T. Role of Hsps in DNA damage and possible significance in diseases. The international Conference on Environmental and genetical Damage, and 12th Congress of the Chinese Environmental Mutagen Society. Nov 3-6, Zhongqing, China. P29-36. (Invited speaker )

38. Yang X, Gong Z, Wang F, Yuan J, Tanguay RM, Wu T*. Possible significance of heat shock proteins in lung cancer and chronic obstructive pulmonary diseases. 2nd International Congress on Stress Response in Biology and Medicine. Tomar, Portugal, Sep24-28th, 2005. P42. (Invited speaker and Chairman)

39. Yuan J, Xiao C, Xu Z, Wei Q, Wu T. Possible role of over-expressed Hsp70 in etoposide-induced DNA damage and apoptosis of L-02 cells. 13th NA ISSX/20th JSSX Meeting, Maui, Hawaii, USA, Oct 23-27. No: 267. Drug Metab Rev, 2005, 37(Supple 2): 153 (SCI, IF=5.4) (Poster)

40. Yang X, Bai Y, Wang H, Yuan J, Chen W, Wu T. Association of HSP70 gene polymorphisms with DNA damage in lymphocytes among coke oven workers. 13th NA ISSX/20th JSSX Meeting, Maui, Hawaii, USA, Oct 23-27 No: 649. Drug Metab Rev, 2005, 37(Supple 2): 351 (SCI, IF=5.4) (Poster)

41. Chen Y, Bai Y, Yang X, Yuan J, Chen W, Wu T. Association of AhR and CYP1A1 genotypes with peripheral blood lymphocyte DNA damage in coke oven workers. 13th NA ISSX/20th JSSX Meeting, Maui, Hawaii, USA, Oct 23-27, 2005. No: 650. Drug Metab Rev, 2005, 37(Supple 2): 351 (SCI, IF=5.4) (Poster)

42. Xu Z, Yuan J, Chen W, Gao J, Wu T. Co-localization of HSP70 and P53 in human embryonic lung cells induced by benzo a pyrene. 13th NA ISSX/20th JSSX Meeting, Maui, Hawaii, USA, Oct 23-27 Drug Metab Rev, 2005, 37(Supple 2): 352 (SCI, IF=5.4) (Poster)

43. Duan Y, Yuan J, Long Z, Chen W, Niu P, Wu T. Characteristics ofHSP27 and HSP70expressions in A549 cells caused by BPDE. 13th NA ISSX/20th JSSX Meeting, Maui, Hawaii, USA, Oct 23-27 No: 652. Drug Metab Rev, 2005, 37(Supple 2): 352 (SCI, IF=5.4) (Poster)

44. Zhang X, He M, Guo H, Wu T. Genetic Variations of HSPs in Environmental Stresses and Diseases, 6th International Workshop on the Molecular Biology of Stress Responses, 2008, March25-29, Bangkok, Thailand ( Invited speaker and Chairman).

45. Wu T*. Using Hsp70 as biomarkers for assessing coke oven exposure and susceptibility among steel workers. The 7th international Symposium on Biological Monitoring in Occupational & Environmental Health, Sep10-12, 2006，Beijing, China.

46. Wu T. Heat shock proteins in the environmental stresses and diseases: protection or danger markers? 5th International Workshop on the Molecular Biology of Stress Responses, 2006, March21-25, University of Concepcion, Concepcion, Chile (Invited speaker)

47. Wu T. Heat-Shock Proteins, Stress, and Environmental Diseases. （ First International Conference on Frontiers in Biomedical and Environmental Health Sciences: from Molecular and Systems Biology to Human Diseases）”， Jun 2630, 2006,Wuhan, China (Chairman).

48. Zhang X, He M, Guo H, Wu T. Genetic Variations of HSPs in Environmental Stresses and Diseases, 6th International Workshop on the Molecular Biology of Stress Responses, 2008, March 25-29, Bangkok, Thailand (Invited speaker and Chairman).

49. Wu T. Biomarker for occupational exposure to coke oven emissions. Symposium on Occupational Health Standard by Chinese and German Scientists. June 16-20, 2008. Wuhan, China. ( Invited speaker).

50. Yang X, Wang H, Guo H, Wu T. Using Heat Shock Protein 70 as Biomarkers for Assessing Coke Oven Exposure and Susceptibility among Steel Workers. Research Center’ Conference in Korea University. May 1, 2008. Seoul, Korea. ( Invited speaker)

51. Wu T. Possible role of genetical variations of heat shock protein genes in the workers to exposed to polycyclic aromatic hydrocarbons and patients with lung cancer. Second International Conference on Frontiers in Biomedical and Environmental Health Sciences: DNA Repair and Cancer Biology, April 16 – 20, 2008, Linquan Villa, Hangzhou, China. ( Invited speaker).

52. Wu T. Circulating Hsp60, 70 and their antibodies predict risk of coronary heart diseases. 4th International Congress on Stress Response in Biology and Medicine. Sapporo, Japan. Oct 6-9, 2009. (Invited speaker).

53. Zhang X. Higher levels of antibody to heat shock protein 70 are associated with lower risk of coronary heart diseases. 4th International Congress on Stress Response in Biology and Medicine. Sapporo, Japan. Oct 6-9, 2009.

54. Guo H, Bai Y, Xu P, Liu L, Wang F, Wang F, Deng Q, Tu Y, Feng M, Lu D, Shen H, Wu T. A functional promoter -1271G>C variant of HSPB1 was assoated with lung cancer risk and survival. 4th International Congress on Stress Response in Biology and Medicine. Sapporo, Japan. Oct 6-9, 2009.

55. Wu T. A Functional Promoter -1271G>C Variant of HSPB1 Predicts Lung Cancer Risk and Survival. Institute for Frontier Med Sci, Kyoto Univ, Japan. Oct 5, 2009. (Invited speaker).

56. Guo H, Wang F, Wu T. Genetic variants of nucleotide excision repair and heat shock proteins genes are associated with DNA damage in coke oven workers and risk of lung cancer. International Conference on Biomedical and Environmental Science & Technology. Beijing, China, May 9-12,2010. (Invited speaker).

57. Tangchun Wu, Air pollution, Health outcomes and possible mechanism, 45th APEC of Public Health, Oct26-28, 2013, Wuhan, China (Co-chair, invited speaker)

58. Tangchun Wu, Air Pollution and Health in China, The second Environment Asia International Conference on Human Vulnerability and Global Environmental Change. May 15-17, 2014, Chonburi, Thailand (Co-chair, invited speaker)

59. Tangchun Wu, Air pollution, early damage and diseases. The Fourteenth International Conference on Combined Actions and Combined Effects of Environmental Factors, Oct 13-16, 2013, Wuhan, China (Chair, invited speaker)

i- Publications in refereed journals (in Chinese)

1. Wu Yang, Wu T, He Hanzhen and Zhang Guogao. The purification, identification and characterization of HSP70. J. Tongji Med. Univ., 19 (suppl): 5, 1990.

2. Xiong Yili and Wu T. The effects of high temperature on the synthesis of HSP70 in rats. Chinese J Aviation Med., 6(4): 6, 1995.

3. Wu T, Wu Yang, Feng Jiade, He Hanzhen ,R M Tangauay and Zhang Guogao. The level of antibodies to HSPs in the workers exposed to heat and carbon monoxide. J. Chinese Labor Health & Occupational Diseases, 13(1):1, 1995.

4. Zhang Guogao, He Hanzhen, Wu Yang and Wu T. Studies on heat stress proteins. Occupational Health. Basic Med. & Clin., 15(2):7, 1995.

5. Wu T, Zhen Wei,Yang Lei, He Hanzhen, Zhang Guogao. The combined effects of high temperature and carbon monoxide on the activities of SOD in red blood cells of workers. Industrial Health & Occupational Diseases, 21(1): 25, 1995.

6. Wu T, Yuan Ye, Xu Daigen, He Hanzhen and Zhang Guogao. Analysis of free amino acids in plasma of workers exposed to heat, carbon monoxide and both. Industrial Health & Occupational Diseases, 21(1): 28, 1995.

7. Wu T, Lai Siying, Zhang Wei, He Hanzhen and Zhang Guogao. The combined effects of high temperature and carbon monoxide on the level of growth hormone and cortisteroid. Industrial Health & Occupational Diseases, 21(1): 31, 1995.

8. Wu T, Wu Yang, He Hanzhen and Zhang Guogao. Analysis of amino acid composition of purified HSP70 from different origins. J. Chinese Labor Health & Occupational Diseases, 13(3): 147, 1995.

9. Wu Yang, Zhang Wei, Xu Daigen, Wu T, He Hanzhen and Zhang Guogao. Studies on induction, localization and redistribution of heat shock proteins. J. Tongji Med.Univ., 24(6):248, 1995.

10. Wu Yang, Wu T, Zhang Wei, He Hanzhen and Zhang Guogao. Immunohistochemical localization of HSP70 and fibronectin in rabbits during heat shock and heat tolerance. Occupational Medicine, 22(5):2, 1995.

11. Wu Yang, Wu T, He Hanzhen and Zhang Guogao. The effects of heat exposure and heat acclimatization on the immune system of rabbits. Labor Medicine, 12(1):1, 1995.
12. Wu T, Zhang Jiamin , Qu Chen, Yu Yongjian, He Hanzhen and Zhang Guogao. The combined effects of high temperature and carbon monoxide on rat HSP70 mRNA and its synthesis. China Industrial Medicine, 8(6):326, 1995.

13. Shi Wuxiang, Chen Sheng, Wu T, He Hanzhen and Zhang Guogao. The effects of various occupational hazards in Coal Gas Plant on the worker’ health and preventive Measures. Occupational Medicine, 22(3): 2, 1995.

14. Chen Sheng, Feng Jiade, Wu T, He hanzhen and Zhang Guogao. Studies on the DNA damage of lymphocytes in workers exposed to various kinds of chemicals. J. Chinese Labor Health & Occupational Diseases, 13(6): 376, 1995.

15. Wu T, and Xiong Yili. The effects of acute heat stress on DNA damage of lymphocytes in pilots. China Industrial Medicine, 9(3)-129, 1996.

16. Wu T, and Xiong Yili. Study on the effects of acute heat stress on the synthesis of HSP70 and its mRNA in lymphocytes of pilots. J. Chinese Labor Health & Occupational Diseases 14(3): 178, 1996.

17. Xiong Yili and Wu T. The dynamic changes of electrocardiograms of pilots during acute heat stress and flight stress. Occupational Medicine , 23(3):6, 1996.

18. Xiong Yili and Wu T. The changes of various kinds of hormones in serum of pilots during acute heat stress and flight stress. J. Chinese Labor Health & Occupational Diseases 14(4): 224, 1996.

19. Wu T, Xiong Yili and Zhang Guogao. Investigation and analysis of antibodies to HSPs in pilots. Occupational Medicine 23(4): 5, 1996.

20. Yuan Ye, Wu T, He Hanzhen and Zhang Guogao. Investigation of antibodies to HSPs in workers exposed to different concentration of benzene. Industrial Health & Occupational Diseases 22(2): 80, 1996.

21. Yuan Ye, Wu T, Chen Cheng and Zhang Guogao. The level of DNA damage in lymphocytes of workers exposed to different concentration of benzene. Industrial Health & Occupational Diseases 22(2): 83, 1996.

22. Yuan Ye, Chen Sheng and Wu T and Zhang Guogao. The detection of SOD in serum of workers exposed to different concentration of benzene. Industrial Health & Occupational Diseases 22(2): 86, 1996.

23. Xiong Yili,Wu T,He Raosheng Yuan Ye, Pan Qiuping and Tan Pingtao. Effects of acute heat stress and flight in the summer on the plasma levels of heat shock proteins in pilots. Chin J Aviat Med, 7(4):225, 1996.

24. Wu T, and Xiong Yili. The effects of acute heat stress on the visual, hearing and acting reaction time of pilots. Industrial Health & Injury. 12(1):

25, 1996. 25. Wu T,He Xiaosheng ,Yuan Ye, Pan Qiuping, Tan Pingtao and Xiong Yili. Study on the effects of simulated flight at low atomospheric pressure on the main HSPs of rats. Industrial Health & Occupational Diseases 23(2): 66, 1997.

26. Wu T, Yang Wu Zhang Wei, He Hanzhen and Zhang Guogao. The determination of HSP70 antigen and antibodies with western blot. J Tongji Med Univ.26(5): 351, 1997.

27. Wu T, Yuan Ye, Chen Sheng, He Hanzhen, RM Tanguay and Zhang Guogao. Study on the relationship between benzene poisoning and antibodies against heat stress proteins. J Occup Health and Injury. 13(1): 1, 1998.

28. Wu T, He Xioa Sheng, He Hanzhen, Zhang Guogao, Liu Timin and Chen Sheng. Experimental study on new type of drink for thermotolerance and health care. J Occup Health and Damage. 13(2): 65, 1998.

29. Wu T, Chen Sheng, Hai Tao, Xiao Chengfeng,Wang Ruibo. Determination of titer of antibodies against heat stress proteins in parachutists after parachuting. J Labor Med. 15(2): 73, 1998.

30. Xiong Yili, Wu T, Leng Shuntang, Chen Sheng, Xiao Chengfeng, Hai Tao. Study on the changes of plasma endolin and renin angiotensin-aldosterone system after parachuting in parachutists. Space Med & Med Engineering, 11(4): 294, 1998.

31. He Hanzhen, Wu T, Pan Qiuping, Wu Yang, Gong Xiaoliang, Lu Ruqian, Chen De Qian, Zhang Guogao. Study on the role of HSPs in heat acclimatization and thermotolerance. Chin J Ind Hyg Occup Dis, 16(2): 70, 1998.

32. Wu T, Zhang Yongxin, Chen Sheng, He Hanzhen, RM Tanguay, Zhang Guogao. The analysis on the property changes of HSP23 expressed by CV-1 cells after transfection with Drosophila HSP23 gene. Chin J Ind Hyg Occup Dis, 16(2): 74, 1998.

33. Zhang Yongxing, He Hanzhen, Wu T , Hai Tao, Lu Turong,Zhang Guogao. Study on the expession of HSP70, HSP27 and p53 in occupational cancer. Chin J Ind Hyg Occup Dis,16(2): 78, 1998.

34. He Xiaosheng, Wu T , Chen Sheng, Wang Ruibo, He Hanzhen and Zhang Guogao. A study of the effects of health care drink for thermotolerance on the induction of HSPs synthesis in vivo. Chin J Ind Hyg Occup Dis,16(2): 85, 1998.

35. Zhang Guogao, He Hanzhen and Wu T. A respective of heat stress proteins and their application in occupation health. Chin J Ind Hyg Occup Dis,16(2): 67, 1998.

36. Tan Pingtao, He Hanzhen, Wu T and Zhang Guogao. The combined effects of nicotine and high temperature on the expression and synthesis of HSP27 in rats. Health Research, 27(suppl): 36, 1998.

37. Wang Xiuling, Jin Xipeng, Zhou Tong, Chen Sheng and Wu T. The measurement of autoantibody to heat stress protein and heat stress protein in plasma of workers exposed to toluene and xylene. J Labour Med,15(2): 69, 1998.

38. Hai Tao, Chen Sheng, Wang Ruibo, Wu T, Ding Yanyan, Wu Furong, Wan Caizhen, Zhen Dan, Zhang Xioa Min, Sun Enlin. Study on the level of tumor necrosis factor and the dilution of antibody to heat stress protein in workers exposed to coke oven emission. Indus Health Occup Dis,24(6): 343, 1998.

39. Sun Enlin, Lu Qiaofa, Ding Yanyan, Pan Haizhu, Xie Tiaoyun, Jing Liya, Qiu Wenbo, Hai Tao, Chen Sheng, Wang Ruibo, Wu T. Effects of the activity of serum superoxide dimutase and lipid peroxides level in workers exposed to coke oven emission. Indus Health Occup Dis,24(6): 346, 1998.

40. Hai Tao,Liu Zhan, Chen Sheng, Wang Ruibo, Wu T, Liu Guozhu, Pan Haizhu, Xie Tanyun, Jing Liya, Ding Yanyan, Sun Enlin. Study on the damage of cell genotoxicity induced by coke oven emission in workers. Indus Health Occup Dis,24(6): 349, 1998.

41. Wu T, Chen Sheng, Hai Tao,Xiao Chengfeng, Wang Ruibo, Xiong Yili, Leng Suntang, Liyu Posheng. Analysis on the effects of parachuting stress on metabolic hormones. Occup Health & Injury,13(4): 212, 1998.

42. Wu T, Chen Sheng, Hai Tao, Xiao Chengfeng, Wang Ruibo, Xiong Zhaodong, Xiong Yili,Leng Suntang, Liu Pengsheng. The effects of parachuting stress on Hsp71 and TNF in plasma of parachutor. Chin J Ind Hyg Occup Dis,17(2): 99, 1999.

43. Chen Sheng, Wu T, Hai Tao, Wang Ruibo and He Hanzhen. The determination of titer of plasma anti-Hsp71. Chin J Ind Hyg Occup Dis,17(2): 100, 1999.

44. Wu T, Chen Sheng, Liu Bing,Wu Zihao,, Zhang Xueling, Xu Wen. Effects of marching with 15kg loading in dry heat desert on GSH and SOD in plasma of soldiers. Chin Occup Med,26(4): 15-17, 1999.

45. Sheng Chen, Xun Yun, Xiao Chengfeng, Wu T, et al. Study on the levels of HSPs in workers exposed to benzene occupationally. Chin Indust. Med. 12(5): 256, 1999.

46. Pan qiuping, Sun Enlin, Sheng Chen, Wu T, hanzhen He, Guogao Zhang. The level of p21(ras) and HSPs in coke oven workers and occupational lung cancer patients. Chin Occup Med, 26(5): 4-7, 1999.

47. Wu T, Hanzhen He and Guogao Zhang. The advancement and perspective of heat stress proteins’ research. J Chin Prevent. Med. 34(1): 6, 2000.

48. Sheng Chen, Dong Meijie, Zhu Haiyan, Wu T, et al. Analysis of the titer of the antibody to HSP70 in serum of workers exposed to benzene. J Chin Prevent. Med. 34(1): 8, 2000.

49. Wang Zizheng,Wang Changlai, Mao Zhicheng, Wang Shuikuan,Pan Weilin,Dai Guoqian, Wu Jiangzhong, Chen Sheng, Wu T. A study on relationship between plasma heat stress protein 70 and cytokine in patients with heat apoplexy. J Chin Prevent. Med. 34(1): 11, 2000.

50. Ma Jinxiang, Sun Yehuan,Cao Duozhi,Chen Sheng,Xiao Chengfeng,Wu Jingun,Wu T. Preliminary study on relationship between antibody against heat stress protein 70 and hypertension. J Chin Prevent. Med. 34(1): 14, 2000.

51. Xiao Chengfeng, Sheng Chen, Gao Yajuan, Wang Ruibo, Wu T. Role of HSP71 in apoptosis of human hepatocyte L-02 induced by etoposide. J Chin labor Health. & Occup. Diseases 18: 78, 2000.

52. Xiao Chenfeng, Sheng Chen, Gao Yajuan, Wu T. Effect of quercetin on HSP71 synthesis in hepatocyte L-02. J Chin Prevent. Med. 34: 33, 2000

53. Wang C, Wang Z, Chen S, Mao Z, Xiao C, Wang S,Gao Y, Gai G, Wang R, Wu T. Analysis on the significance of plasma heat stress protein 70 and Hsp70 antibody in patients with heat illness. J Chin labor Health. & Occup. Diseases 18: 36, 2000.

54. Gao Y, Chen S, Xiao C, Wang R, He H, Wu T. Study on the relationship between HSP70 and DNA damage in human embryonic lung cells by benzo(a) pyrene metabolites. J Chin labor Health. & Occup. Diseases 18: 321-324, 2000.

55. Chen S, Hai T Wang R, Xiao C, Gao Y, Lu Q, Li J, Wu T. The relationship between HSP70 level and genotoxic damage in peripheral blood lymphocytes of workers exposed to coke oven emission. J Chin labor Health. & Occup. Diseases 18: 324-326, 2000.

56. Pan Q, Xiao C, Wu F, Xie M, Chen S, Wang F, Zhang L, Mao Z, Wu T. Study on the possibility of antibodies against main heat shock proteins as biomarkers of susceptibility to heat –stroke. J Chin labor Health. & Occup. Diseases 18: 330-332, 2000.

57. Wu T, He H, Zhang G. Research advancement and perspective of heat shock response. J Chin labor Health. & Occup. Diseases 18: 365-367, 2000.

58. Wang P, Wu Z, Xiao B, Wu T. The role of heat shock protein 70 and its autoantibody in experimental autoimmune inner ear disease. Chin J Otorhinolarygol, 35:10-13,2000.

59. Xiao C, Chen S, Pan Q, Ke L, Liu Z, Wang R, Gao Y, He H, Wu T. Detection of heat stress protein 70 in peripheral blood lymphocytes by flow cytometry. J Chin labor Health. & Occup. Diseases 19: 59-61, 2001.

60. Xiao C, Pan Q, Chen S, Wu F, Ren A, Gao Y, Yang J, He Q, He H, Wu T. Basal and inducible levels of heat stress protein 71 in peripheral blood lymphocytes in soldiers with heat illness. J Chin labor Health. & Occup. Diseases 19: 178-180, 2001

61. Ma J, Sun Y, Gao Y, Xiao C, Wang R, Zao D, Wu T. Seroepidemiological investigation on the presence of antibodies to heat shock protein 70 in integrated iron and steel workers exposed to abnormal stress in working environment. J Chin labor Health. & Occup. Diseases 19: 181-183, 2001

62. Mei T, Xiao C, Xie M, Wu T. Relationship between antibodies to main heat stress proteins and hypertension in railway policemen. J Chin labor Health. & Occup. Diseases 19:363-365,2001

63. Mei T, Xiao C, Xie M, Wu T. Relationship between the level of plasma nitrogen monoxide and lipid peroxidation and hypertension in railway policemen. Indust Health. & Occup. Diseases 127: 273-275, 2001

64. Zeng H, Xiao C, Jing X, Yang M, Ke L, Xu Q, Tang H, Li F, Wu T. Analysis of difference in the expression of Hsp71 in soldiers from different climatic area. J Chin labor Health. & Occup. Diseases 20: 282-284, 2002

65. Tu B, Chen S, Xiao C, Gao Y, He H, Wu T. Morphological changes of brain tissues in rats caused by benzo a pyrene. J Chin labor Health. & Occup. Diseases 20: 58-60, 2002

66. Tu B, Chen S, Xiao C, Gao Y, He H, Wu T. Morphological changes and apoptosis of nervous tissues in rats caused by benzo a pyrene. J Chin labor Health. & Occup. Diseases 20: 296-299, 2002

67. Yang M, Huang Q, Wang R, Tang H, Ke L, Xiao C, Wu T. Purification of Hsp70 peptide complex. J Huazhong Univ Sci Tech (Medicine).31（3）：245-247,2002.

68. Tu B, Chen S, Xiao C, Gao Y, Tang H, Ke L,He H, Wu T. Morphological and behaviour study of neurotoxicity of rats caused by benzo a pyrene. Indust Health. & Occup. Diseases 28: 94-98, 2002.

69. Jin X，Yang L, Chen M, Feng D Fu X, Deng J, Wu T. Levels of Hsp70 in lymphocytes of healthy elders. Chinese Aging Med. 2003，22（2）：92-94

70. Yang J, Xiao C, Yang X, Xu Q, Ke L, He H, Hu B, Wu T. The effects of benzo a pyrene on proliferation of endolieal cells and Hsp70 expression. Health Res, 2003，32（2）：92~94.

71. Lu Q, Bei M, Zhang H, Li J, Xiao C, Chen S, Wu T. The possible roles of detections of P21, P53 and Hsp70 in the diagnosis of BaP related lung cancer. J. Chinese Labor Health & Occupational Diseases, 2003，21（5）：359-361

72. Yang J, Jiang C, Ke L, Xu Q, Yang M, He H, Hu B, Wu T. The expression of Cyp 4501A1 in endothelial cells induced by BaP. J. Chinese Labor Health & Occupational Diseases, 2003,21(5):362-364

73. He Q, Yang J, Xiao C, Wu T. Development of double antibodies sandwich ELISA Method for Detecting HSP70 in Plasma and Its Primary Application. Environ and Labor Med, 2004, 21(1):27-32

74. Li F, Jiang C, Sun S, He M, Zhang S, Liao R, Jia S, Zeng H, Wu T. The effect of high altitude on lipid peroxide and anti-oxidation system. Environ and Labor Med, 2004,21(1):37-43

75. Yang J, Ke L, Jiang C, Xu Q, He H, Hu B, Wu T. Inhibited effects of vitamin E and vitamin C on HSP70 Change in endothelial cells by benzo(a)pryene. Environ and Labor Med, 2004,21(1):7-10

76. Yang J, Ke L, Jiang C, Xu Q, Wang F, He H, Hu B, Wu T. Role of Protein Kinase C in the Change of HSP70 Gene Expression Caused by Benzo(a)pyrene. Environ and Labor Med .2004,21(1):4-7

77. Yang J, Ke L, Jiang C, Xu Q, Bai Y, He H, Hu B, Wu T. Effects of Benzo(a)pyrene on Heat Shock Factor 1. Environ and Labor Med, 2004, 21(2): 107-110

78. Xu Z, Yang J, Yang M, He M,XuQ, BaiY,Xu Q,He H, Hu B, Wu T. Interferential Effects of Vitamin E and Vitamin C on HSP70 Expressions of Endothelial Cells caused by Benzo(a)pyrene. Environ and Labor Med, 2004,21(2): 111-113.

79. Ke L, Huangpu Y, Wang Z, Ren A, Wang S, Xiao C, Wu T. Difference of HSP70 Expressions in Lymphocytes Incubated at Low and High Temperature from Soldiers Lived in South and North China. Environ and Labor Med ,2004,21(2): 114-116
80. Yang M, Tan H, Chen Y, Wang F, He M, Jiang C, Chen S, Wu T. The Change of plasma antibodies against Hsp71 in coronary heart diseases. Environ and Labor Med ,2004,21(2): 139-140.

81.Yang J, Ke L, Jiang C, Xu Q, Xu Q, He H, He H, Hu B, Wu T. Effects of MAPK signal transduction pathways on HSP70 gene expression in endothelial cells exposed by benzo(a)pryene. J. Chinese Labor Health & Occupational Diseases 2004, 22(2):100-103

82. Xu Q, Yang J, Jiang C, Yang M, Ke L, He M, Wang F, Wu T. The role of heat shock protein 70 in DNA damage under benzo a pyrene. J. Chinese Labor Health & Occupational Diseases 2004, 22(2): 96 – 99

83. Jiang C, Li F, Sun S, He M, Zhang S, Miao R, Jia S, Zeng H, Wu T. The significance of balance of lipid peroxidation and anti-oxidation in acute high altitude. J. Chinese Labor Health & Occupational Diseases 2004, 22(2):100-103.

84. Zhang E, Yang J, Xiao C, Yang M, Chen S, He H, Wu T. Occupational hazard in different workers for road-caring and its relationship with lipid oxidation. Indust Health. & Occup. Diseases 2004,30(3): 152-153.

85. Zhang E, Yang J, Xiao C, Xu Q, Chen S,He H, Wu T. Plasma antibodies against Hsp70 in different workers for road-caring. Indust Health. & Occup. Diseases 2004,30(3): 149-151.

86. Wang H, Zhang E, Xiao C, Yang J, Ke L, Chen S, He H, Wu T. Retrospective analysis of life expectation and death cause in different workers for road-caring. Indust Health. & Occup. Diseases 2004,30(3): 154-157.

87. Zhou F, Li F, Jiang C, Sun S, He M, Zhang S, Liao R, Jia S, Zeng H, Wu T. The relationship between polymorphism of HSP70-hom and susceptibility of high altitude illness. Indust Health. & Occup. Diseases 2005,31(1)：29-31

88. He M, Zhang K,Fu Y,Li F,Chen H, Liu L, Jiang C,Wu T. Levels of lipid peroxidation and anti-oxidation in policemen from different climatic zones. Indust Health. & Occup. Diseases 2004,30(4)：207-209.

89. Yi J, Liu Z, Li G, Wang R, Wang X, Yu Q, Wu T. Experimental study on damage of endothelial cells caused by sulphide dioxide and interventioned effects of vitamin C. J. Chinese Labor Health & Occupational Diseases 2004, 22(3): 215-216.

References

Robert M. Tanguay. My supervisor in Canada, Professor of Medicine (Genetics) and Director of Research Centre in Life and Health Sciences, Parvillon Marchand, Laval University, Quebec, Canada G1K 7P4. Phone: 418-656-7079 Fax:418-656-7176 E-mail: Robert.Tanguay@rsvs.ulaval.ca

Zhang Guogao* and He Hanzhen. My M.D. and Master Degree of Medicine supervisor respectively, Professor and Director, Institute of Occupational Medicine, Tongji Medical University, Wuhan 430030, P.R. China. Fax: 86-27-83692560.