Adjunct Professor in　School of Public Health and Primary Care, The Chinese University of Hong Kong

Weihong Chen is Professor and Chiefof Department of Occupational Health and Environmental Health in School of Public Health in Tongji Medical College in University of Science & Technology. She is also Adjunct Professor in the Chinese University of Hong Kong.She obtained her bachelor and master degree inTongji Medical University and Doctor Degree in Essen University of Germany in 2001.Her major research interests include (1) Epidemiology study on adverse health effects and preventive strategy of particulate matter including industrial dusts. (2) The pathogenic mechanism of ambient particle matters to cause cardiopulmonary diseases. (3) Evaluation on protective effects of personal respiratory protection equipment. Dr. Chenis a member of Chinese National Occupational Standards Committee and fellow of many national and international professional colleges and institutions in occupational health medicine and public heath. Dr. Chen obtained Alice Hamilton Award of US NIOSH in 2006, one first class prizes of Hubei Scientific and Technology Progress Award in 2007 and one second class prizes of Chinese State Scientific and Technological Progress Award in 2014.There are more than 160 papers were published by Dr. Chen and her group.

Education

1985/09-1990/07   Bachelor’s Degree of Medicine

The Faculty of Preventive Medicine
Tongji Medical University

1990/09-1993/07    Master’s Degree of Medicine

Dept. of Labor Health and Occupational Diseases
Tongji Medical University

1999/03-2001/09    Doctoral Degree of Medicine

Institute of Hygiene and Occupational Medicine
Medical School, University of Essen, Germany

Languages

Chinese, English, German

Work Experience

1993/07-1996/12    lecturer

Department of Labor Health and Occupational Diseases
School of Public Health, TongjiMedical University

1997/01-1997/07    Visiting scientist

Exposure Assessment Branch
National Institute for Occupational Safety and Health (NIOSH)
Centers for Diseases Control and Prevention (CDC)
Morgantown, WV, USA.

1997/07-1999/02     Assistant Professor

Department of Labor Health and Occupational Diseases
School of Public Health, Tongji Medical University
1999/03-2003/12 Research Assistant, then senior researcher (from Sep,2002)
Institute of Hygiene and Occupational Medicine
Medical School, University of Essen, Essen, Germany.

2010/08-2010/09    Visiting professor

Department of Occupational and Environmental Health
School of Public Health
Emory University, USA

2010/09-2010/11   Visiting scientist

Surveillance Branch
Division of Respiratory Disease Studies,
NIOSHin Centers for Diseases Control and Prevention (CDC), Morgantown, WV, USA.

2004/01-present  Professor and chief in Department of Occupational and Environmental Healthand Ministry of Education Key Lab for Environment andHealth, School of Public Health

Tongji Medical College
Huazhong University of Science and Technology.

2012/07-present   Adjunct Professor

School of Public Health and Primary Care,
The Chinese University of Hong Kong

Research interests

1. Health effects (on human) of particulate matter exposure, especially respiratory diseases.

2. The pathogenic mechanism of particle matter to cause cardiopulmonary diseases.

3. Evaluation of personal respiratory protection equipment.

Previous Funding

1. Study of silicosis and lung cancer for dust exposed workers. Cooperation with US National Instituteof Cancer and National Institute for Occupational Health and Safety. From 1986/01 to 2003/12

2. Epidemiologicalevidence quartz, silicosis and lung cancer: Chinese cohort study, re-analysis. Support by Institute for Occupational Health and Safety in HVBG, Germany. From 2004/01 to 2012/12. (PI， Euro 220，000)

3. The role of neurogenic inflammation on earlier damage induced by crystalline silica. Support by National Natural Science Foundation in China (NNSFC)(30571553) From 2006/01 to 2008/12.(250,000 RMB). (PI)

4. Head-and-Face Anthropometric Survey of Chinese Workers. Support by US NIOSH, 2006/01 to 2008/12.($37,600)(PI)

5. Adverse health effects of industrial dust and prevent strage. Support by Ministry of Education (NCET-05-0646). 2005/01-2008/12.(PI)

6. Classification of occupation exposure to industrial dust. Support by Ministry of Health（2008-03-01）. From 2008/09 to 2010/08. (PI)

7. Laboratory study to assess causative factors affecting temporal changes in filtering-facepiecerespirator fitSupport by US NIOSH, 2006/01 to 2008/12.($32,900)(PI)

8. The role and mechanism of Nalp3 in the fibrosis induced by crystalline silica. Support by NNSFC(30972451)From 2010/01 to 2012/12.(360,000 RMB). (PI)

9. Evaluation of the test performance and cost-effectiveness of medical surveillance programs for workers exposed to silica dusts. Supported by PneumoconiosisCompensationFundBoard(PCFB) in HongKong. From 2009/09 to 2012/08. (Co-PI, cooperated with Prof. Tse Lap in The Chinese University of Hong Kong.)

10. Fit Test Panels for Self-inhalation Air-purifying Respiratory Protective Equipment. Support by Ministry of Health (2009-03-08). From 2009/11 to 2011/10. (PI)

11. The limitation and determining method for PCDD/Fs. Support by Ministry of Health (2009-03-10). From 2009/11 to 2011/10. (PI)

12. Thestudy on early respiratory injury of PM and its mechanisms. (sub project of Basic studies on health hazards caused by ambient particulate matter). Supported byresearch funds from the National Key Basic Research and Development Program(2011CB503804). From 2011/01 to 2015/08. (4,420,000 RMB) (PI).

13. Research on human exposure assessment technology for typical environmental PCDD/Fsexposure. Supported by Environmental protection public welfare industry research special. From 2013/01 to 2015/12. (5,930,000RMB)(PI)

Present Active Research Programs

1. The role and mechanisof TAM/Gas6 in the inflammation response and fibrosis induced by crystalline silica.Supported by NSFC(81372967). From 2014/01 to 2017/12. (800,000RMB）(PI)

2. The role and mechanism of Nalp3 inflammasome in work-related knee osteoarthritis. Supported by NSFC(81573121). From 2016/01 to 2019/12. (840,000RMB）(PI)

3. Molecular epidemiological study of decline in lung function and chronic obstructive pulmonary disase caused by airborne fine particulate matter. Supported by NSFC(91543207). From 2016/01 to 2019/12. (2,800,000RMB）(PI)

Publicahtion in peer-reviewed journals (in English) (*correspond author)

1. Yun Zhou, Huizhen Sun H, Xie J, Song Y, Liu Y, Huang X, Zhou T, Rong Y, Wu T, Yuan J*, Chen W*. Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Altered Lung Function in Wuhan, China. Am J RespirCrit Care Med. 2015 Dec 4. [Epub ahead of print]

2. Rong Y, Luo X, Zhang Z, Cui X, Liu Y, Chen W*. Occupational exposure to asbestos and cardiovascular related diseases:A meta-analysis. Preventive Medicine Reports. 2015, 2:920-826

3. Rong Y, Yan S, Zhang Z, Cui X, Xiao L, Liu Y, Luo X, Chen W*. Blocking TGF-rmbeta expression inhibits silica particle-induced epithelialmesenchymaltransition in human lung epithelial cells. Environ ToxicolPharmacol. 2015, 40(3):861-869

4. Weng S, Wang L, Rong Y, Liu Y, Wang X, Guan H, Chen W*. Effects of the interactions between dust exposure and genetic polymorphisms in Nalp3, caspase-1, and IL-1β on the risk of silicosis: A case-control study. PLoS One. 2015,10(10):e0140952

5. Tse LA*, Dai J, Chen M, Liu Y, Zhang H, Wong TW, Leung CC, Kromhout H, Meijer E, Liu S, Wang F, Yu IT, Shen H, Chen W*. Prediction models and risk assessment for silicosis using a retrospective cohort study among workers exposed to silica in China.Sci Rep. 2015 Jun 19;5:11059. doi: 10.1038/srep11059

6. Chen W, Cui X, Xing J, Wu T.Response to: Hsp27 and Hsp70 in chronic obstructive pulmonary disease.Cell Stress Chaperones. 2015 Sep;20(5):725-6.

7. Liu Y, Wang H, Weng S, Su W, Wang X, Guo Y, Yu D, Du L, Zhou T, Chen W*, Shi T*. Occupational Hearing Loss among Chinese Municipal Solid Waste Landfill Workers: A Cross-Sectional Study.PLoS One. 2015 Jun 4;10(6):e0128719.

8. Guo Y, Shan Z, Ren H, Chen W*. Dairy Consumption and Gastric Cancer Risk: A Meta-Analysis of Epidemiological Studies. Nutrition and Cancer, 2015, 67:4, 555-568.

9. Guo Y, Rong Y, Huang X, Lai H, Luo X, Zhang Z, Liu Y, He M, Wu T, Chen W*. Shift work and the relationship with metabolic syndrome in Chinese aged workers.PLoS One. 2015, 10(3):e0120632.

10. Cui X, Xing J, Liu Y, Zhou Y, Luo X, Zhang Z, Han W, Wu T, Chen W*.COPD and levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes among coal workers: a case-control study.Cell Stress Chaperones. 2015,May;20(3):473-81

11. Zhou T, Cui X, Zhou Y, Guo J, Rong Y, Chen W*.Switch regulation of interleukin-1 beta in downstream of inflammatory cytokines induced by two micro-sized silica particles on differentiated THP-1 macrophages.Environ ToxicolPharmacol. 2015, 39(1):457-66.

12. Liu Y, Xi P, Joseph M, Zhuang Z, Shu C, Jiang L, Bergman M, Chen W*.Variations in Head-and-Face Shape of Chinese Civilian Workers.Ann OccupHyg. 2015, 59(7)：932-44.

13. Gu NL, Shi TM, Zhang ZH, Shao SW, Jing T, Chen WH*.Spectrophotometric determination of silicon tetrahydride in the air of workplace.J HuazhongUnivSciTechnolog Med Sci. 2015 Apr;35(2):188-91.

14. Sun C, Chu M, Chen W, Jin G, Gong J, Zhu M, Yuan J, Dai J, Wang M, Pan Y, Song Y, Ding X, Du M, Dong J, Zhang Z, Hu Z, Wu T, Shen H. Genetic variants of H2AX gene were associated with PM2.5-modulated DNA damage levels in Chinese Han populations.Mutat Res. 2015 May 21;778:41-45.

15. Chu M, Sun C, Chen W, Jin G, Gong J, Zhu M, Yuan J, Dai J, Wang M, Pan Y, Song Y, Ding X, Guo X, Du M, Xia Y, Kan H, Zhang Z, Hu Z, Wu T, Shen H. Personal exposure to PM2.5, genetic variants and DNA damage: A multi-center population-based study in Chinese. ToxicolLett. 2015 Jun 15;235(3):172-8. 45.

16. Feng W, He X, Chen M, Deng S, Qiu G, Li X, Liu C, Li J, Deng Q, Huang S, Wang T, Dai X, Yang B, Yuan J, He M, Zhang X, Chen W, Kan H, Wu T.Urinary metals and heart rate variability: a cross-sectional study of urban adults in wuhan, china.Environ Health Perspect. 2015 Mar;123(3):217-22.

17. Hou F, Huang X, Liu C, Sun H, Zhou T, Song Y, Rong Y, Zhu B, Chen W, Wang J, Wang J, He M, Miao X, Hoffmann B, Wu T, Chen W*, Yuan J*.Housing characteristics in relation to exhaled nitric oxide in China.Am J Health Behav. 2015 Jan;39(1):88-98.

18. Feng Y, Huang X, Sun H, Liu C, Zhang B, Zhang Z, Sharma Tengur V, Chen W, Wu T, Yuan J, Zhang X. Framingham risk score modifies the effect of PM10 on heart rate variability.Sci Total Environ. 2015 Aug 1;523:146-51.

19. Feng W, Cui X, Liu B, Liu C, Xiao Y, Lu W, Guo H, He M, Zhang X, Yuan J, Chen W, Wu T. Association of urinary metal profiles with altered glucose levels and diabetes risk: a population-based study in China.PLoS One. 2015 Apr 13;10(4):e0123742

20. Feng W, Huang X, Zhang C, Liu C, Cui X, Zhou Y, Sun H, Qiu G, Guo H, He M, Zhang X, Yuan J, Chen W, Wu T. The dose-response association of urinary metals with altered pulmonary function and risks of restrictive and obstructive lung diseases: a population-based study in China.BMJ Open. 2015 May 21;5(5):e007643.

21. Hou J, Liu C, Yao P, Chen W, He M, Wang Y, Liang Y, Miao X, Wei S, Xu T, Fang W, Zhu J, Li X, Hu FB, Wu T, Yang H, Yuan J. Association of Adiposity Indices with Platelet Distribution Width and Mean Platelet Volume in Chinese Adults.PLoS One. 2015 Jun 9;10(6):e0129677.

22. Guo J, Shi T, Cu X, Rong Y, Zhou T, Zhang Z, Liu Y, Shen Y, Chen W*. Effects of silica exposure on the cardiac and renal inflammatory and fibrotic response and the antagonistic role of interleukin-1 beta in C57BL/6 mice. Arch Toxicol. 2014, DOI 10.1007/s00204-014-1405-5.

23. Yang L, Zhou Y, Sun H, Lai H, Liu C, Yang K, Yuan J, Wu T, Chen W*, Zhang X*. Dose-response relationship between polycyclic aromatic hydrocarbon metabolites and risk of diabetes in the general Chinese population. EnvrionPollut. 2014,195:24-30.

24. Song Y, Hou J, Huang X, Zhang X, Tan A, Rong Y, Sun H, Zhou Y, Cui X, Yang Y, Guo Y, Zhang Z, Luo X, Zhang B, Hou F, He X, Xie J, Wu T, Chen W* and Yuan J*. The Wuhan-Zhuhai (WHZH) cohort study of environmental air particulate matter and the pathogenesis of cardiopulmonary diseases: study design, methods and baseline characteristics of the cohort. BMC Public Health.2014, 14:994

25. Chu M, J X, Chen W, Zhang R, Sun C, Wang T, Luo C, Gong J, Zhu M, Fan J, Hou Z, Dai J, Jin G, Wu T, Chen F, Hu Z, Ni C, Shen H. A genome-wide association study identifies susceptibility loci of silica-related pneumoconiosis in Han Chinese.Hum Mol Genet. 2014,23(23):6385-94.

26. Liu Y, Rong Y, Steenland K, Christiani DC, Huang X, Wu T, Chen W*.Long-term Exposure to Crystalline Silica and Risk of Heart Disease Mortality.Epidemiology. 2014 ,25(5):689-96.

27. Xing J, Huang X, Yang L, Liu Y, Zhang H, Chen W*. Comparison of High-resolution Computerized Tomography with Film-screen Radiography for the Evaluation of Opacity and the Recognition of Coal Workers’ Pneumoconiosis.J Occup Health. 2014, 56:301-308.

28. Zhou Y, Wang H, Xing J, Liu Y, Cui X, Guo J, Chen W*.Expression levels of surfactant-associated proteins and inflammation cytokines in serum and bronchoalveolar lavage fluid among coal miners: a case-control study. J Occup Environ Med. 2014, 56(5): 484-8.

29. Cheng W, Rong Y, Shi T, Zhou T, Liu Y, Chen W*. Size-dependent biological effects on vascular endothelial cells induced by different particulate matters. Journal of Huazhong University of Science and Technology [Medical Sciences]. 2014, 34(3): 314-321.

30. Yu Y, Jiang L, Zhuang Z, Liu Y, Wang X, Liu J, Yang M,Chen W*. Fitting Characteristics of N95 Filtering-Facepiece Respirators Used Widely in China. PLoS One. 2014,9(1):e85299.

31. He M, Wu C, Xu J, Guo H, Yang H, Zhang X, Sun J, Yu D, Zhou L, Peng T, He Y, Gao Y, Yuan J, Deng Q, Dai X, Tan A, Feng Y, Zhang H, Min X, Yang X, Zhu J, Zhai K, Chang J, Qin X, Tan W, Hu Y, Lang M, Tao S, Li Y, Li Y, Feng J, Li D, Kim ST, Zhang S, Zhang H, Zheng SL, Gui L, Wang Y, Wei S, Wang F, Fang W, Liang Y, Zhai Y, Chen W, Miao X, Zhou G, Hu FB, Lin D, Mo Z, Wu T.A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.Gut. 2014, 63(1):143-51.

32. Tian Y, Shen L, Wu J, Chen W, Yuan J, Yang H, Wang Y, Liang Y, Wu T.Parity and the risk of diabetes mellitus among Chinese women: a cross-sectional evidence from the Tongji-Dongfeng cohort study.PLoS One. 2014 Aug 8;9(8):e104810.

33. Cao Z, Shen L, Wu J, Yang H, Fang W, Chen W, Yuan J, Wang Y, Liang Y, Wu T.The effects of midday nap duration on the risk of hypertension in a middle-aged and older Chinese population: a preliminary evidence from the Tongji-Dongfeng Cohort Study, China.J Hypertens. 2014 Oct;32(10):1993-8

34. Gong J, Zhu M, Chu M, Sun C, Chen W, Jin G, Yuan J, Dai J, Wang M, Pan Y, Song Y, Ding X, Du M, Zhang Z, Hu Z, Wu T, Shen H.Genetic variants in SMARC genes are associated with DNA damage levels in Chinese population.ToxicolLett. 2014 Sep 2;229(2):327-32.

35. Ding X, Wang M, Chu H, Chu M, Na T, Wen Y, Wu D, Han B, Bai Z, Chen W, Yuan J, Wu T, Hu Z, Zhang Z, Shen H.Global gene expression profiling of human bronchial epithelial cells exposed to airborne fine particulate matter collected from Wuhan, China.ToxicolLett. 2014 Jul 3;228(1):25-33

36. Liu C, Yang Y, He M, Yao P, Chen W, Liang Y, Wang Y, Fang W, Zhu J, Li X, Yang H, Yuan J, Hu FB, Wu T.Passive smoke exposure was related to mean platelet volume in never-smokers.Am J Health Behav. 2014 Jul;38(4):519-28.

37. Feng Y, Sun H, Song Y, Bao J, Huang X, Ye J, Yuan J, Chen W, Christiani DC, Wu T, Zhang X.A community study of the effect of polycyclic aromatic hydrocarbon metabolites on heart rate variability based on the Framingham risk score.Occup Environ Med. 2014 May;71(5):338-45.

38. Wang F, Zhu J, Yao P, Li X, He M, Liu Y, Yuan J, Chen W, Zhou L, Min X, Fang W, Liang Y, Wang Y, Wei S, Liu J, Miao X, Lang M, Jiang X, Zhang P, Li D, Lu C, Wang X, Shi W, Zheng J, Guo H, Zhang X, Yang H, Hu FB, Wu T.Cohort Profile: the Dongfeng-Tongji cohort study of retired workers.Int J Epidemiol. 2013, 42(3):731-40.

39. Zhou L, He M, Mo Z, Wu C, Yang H, Yu D, Yang X, Zhang X, Wang Y, Sun J, Gao Y, Tan A, He Y, Zhang H, Qin X, Zhu J, Li H, Lin X, Zhu J, Min X, Lang M, Li D, Zhai K, Chang J, Tan W, Yuan J, Chen W, Wang Y, Wei S, Miao X, Wang F, Fang W, Liang Y, Deng Q, Dai X, Lin D, Huang S, Guo H, Lilly Zheng S, Xu J, Lin D, Hu FB, Wu T.A genome wide association study identifies common variants associated with lipid levels in the Chinese population.PLoS One. 2013 Dec 30;8(12):e82420.

40. Dai X, Yuan J, Yao P, Yang B, Gui L, Zhang X, Guo H, Wang Y, Chen W, Wei S, Miao X, Li X, Min X, Yang H, Fang W, Liang Y, Hu FB, Wu T, He M.Association between serum uric acid and the metabolic syndrome among a middle- and old-age Chinese population.Eur J Epidemiol. 2013 Aug;28(8):669-76.

41. Shen F, Yuan J, Sun Z, Hua Z, Qin T, Yao S, Fan X, Chen W, Liu H, Chen J.Risk identification and prediction of coal workers’ pneumoconiosis in Kailuan Colliery Group in China: a historical cohort study.PLoS One. 2013 Dec 23;8(12):e82181.

42. Chen M, He M, Min X, Pan A, Zhang X, Yao P, Li X, Liu Y, Yuan J, Chen W, Zhou L, Fang W, Liang Y, Wang Y, Miao X, Lang M, Zhang P, Li D, Guo H, Yang H, Hu FB, Wu T.Different physical activity subtypes and risk of metabolic syndrome in middle-aged and older Chinese people.PLoS One. 2013;8(1):e53258.

43. Liu Y, Steenland K, Rong Y, Hnizdo E, Huang X, Zhang H, Shi T, Sun Y, Wu T, Chen W*. Exposure-Response Analysis and Risk Assessment for Lung Cancer in Relation to Silica Exposure: A 44-year Cohort Study of 34,018 Workers. Am J Epidemiol. 2013, 178(9):1424-33.

44. Guo J, Gu N, Chen J, Shi T, Zhou Y, Rong Y, Zhou T, Yang W, Cui X, Chen W*. Neutralization of interleukin‑1 beta attenuates silica‑induced lunginflammation and fibrosis in C57BL/6 mice. Arch Toxicol. 2013, 87:1963–1973. DOI 10.1007/S00204-013-1063-z.

45. Guo Y, Liu Y, Huang X, Rong Y, He M, Wang Y, Yuan J, Wu T, Chen W*.The Effects of Shift Work on Sleeping Quality,Hypertension and Diabetes in Retired Workers. PLoS One. 2013, 8(8):e71107.

46. Rong Y, Zhou T, Cheng W, Guo J, Cui X, Liu Y, Chen W*.Particle-size-dependent cytokine responses andcell damage induced by silica particles andmacrophages-derived mediators in endothelialcell. Environ Toxicol Phar. 2013,36:921-928.

47. Wang L, Weng S, Wen S, Shi T, Sun G, Zneg Y, Qi C, Chen W*. Polychlorinated dibenzo-p-dioxins and dibenzofurans and their association withcancer mortality among workers in one automobile foundry factory. Sci Total Environ. 2013, 443:104-111.

48. Chen W*, Liu Y, Wang H, Hnizdo E, Sun Y, Su L, Zhang X, Weng S, Bochmann F, Hearl F, Chen J, Wu T*. Long-Term Exposure to Silica Dust and Risk of Total and Cause-Specific Mortality in Chinese Workers: A Cohort Study. PLoS Med2012,9(4),e1001206

49. Leung CC*, Yu ITS, Chen W. Silicosis. Lancet. 2012,379:2008-18

50. Yang L, Chen W, Wang Z, Sun J, Wang L, Yi G, Yang J, Li J, Mao G, Mattenklott M, Koob M, Sun Y, Bochmann F, Dahmann D.A comparative field study on dust measurements by different sampling methods with emphasis on estimating factors for recalculation from chinese ‘total dust’ measurements to respirable dust concentrations.Ann OccupHyg. 2012 May;56(4):401-12.

51. Zhou T, Rong Y, Liu Y, Zhou Y, Guo J, Cheng W, Wang H, Chen W*. Association BetweenProinflammatory Responses of Respirable Silica Dust and Adverse Health Effects Among Dust-Exposed Workers. J Occup Environ Med. 2012，54（4）：459-465 IF=1.845

52. Yu Y, Benson S, Cheng W, Hsiao J, Liu Y, Zhuang Z, Chen W*.Digital 3-D Headforms Representative of Chinese Workers. Ann OccupHyg.2012,56(1):113–122.

53. Liu Y, Chen W*. A SAS Macro for Testing Differences among Three or More Independent Groups Using Kruskal-Wallis and Nemenyi Tests. J HuazhongUnivSciTechnol [Med Sci],2012, 32(1):130-134.

54. Sun Y, Bochmann F, Morfeld P, Ulm K, Liu Y, Wang H, Yang L, Chen W*. Chang of exposure response over time and long-term risk of silicosis among a cohort of Chinese pottery workers. Int J Environ Res Public Health. 2011, 7, 2923-2936.

55. Wang H, Xing J, Wang F, Han W, Ren H, Wu T, Chen W*. Expression of Hsp27 and Hsp70 in lymphocytes and plasma in healthy workers and coal miners with lung cancer. J HuazhongUnivSciTechnol [Med Sci], 2010,30(4):415-420

56. Chen W*, Zhuang Z, Benson S, Du L, Yu D, Landsittel D, Wang L, Viscusi D, Shaffer R. New Respirator Fit Test Panels Representing the Current Chinese Civilian Workers. Ann OccupHyg. 2009,53（3）：297-305.

57. Du L, Zhuang Z, Guan Y, Xing J, Tang X, Wang L, Wang Z, Wang H, Liu Y, Su W, Benson S, Gallagher S, Viscusi D,Chen W*. Head-and-Face Anthropometric Survey of Chinese Workers. Ann OccupHyg. 2008, 52（8）：773-782.

58. Zhang X, Wang H, Zhu X, Liu Y, Wang L，Dai Q, Cai N, Wu T, Chen W*. Cohort Mortality Study in Three Ceramic Factories in Jingdezhen in China. J HuazhongUnivSciTechnol［Med Sci］,2008,28(4):386-390

59. Tang Z, Weng S, Peng S, Liu Y, Chen X, Yang J, Lu W, Chen W. Influence of exercise at high temperature on blood biochenical indexes and HSP72 expression in adult males. J HuazhongUnivSciTechnol［Med Sci］,2008,28(5):504-508

60. Chen W, Bochman F, Sun Y. Effects of work related confounders on the association betweensilica exposure and lung cancer: a nested case-control studyamong Chinese miners and pottery workers. Int Arch Occup Environ Health. 2007, 80(4):320-6.

61. Yang X, Zheng J, Bai Y, Tian F, Yuan J, Sun J, Liang H, Guo L, Tan H, Chen W, Tanguay RM, Wu T.Using lymphocyte and plasma Hsp70 as biomarkers for assessing coke oven exposure among steel workers.Environ Health Perspect. 2007 Nov;115(11):1573-7

62. Wang H, Liu A, Zheng H, Guo L, Liang H, Yang X, Bai Y, Chen W, Wu T*. Relationshipbetweenplasma BPDE-albumin adducts and urinary 1-hydroxypyrene among coke oven workers. Biomed Environ Sci，2007，20:179-183

63. Bai Y, Xu L, Yang X, Hu Z, Yuan J, Wang F, Shao M, Yuan W, Qian J, Ma H, Wang Y, Liu H, Chen W, Yang L, Jing G, Huo X, Chen F, Liu Y, Jin L, Wei Q, Huang W, Shen H, Lu D, Wu T.Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study.BMC Cancer. 2007 May 13;7:81.

64. Wang H, Chen W, Zheng H, Guo L, Liang H, Yang X, Bai Y, Sun J, Su Y, Chen Y, Yuan J, Bi Y, Wei Q, Wu TAssociation between plasma BPDE-Alb adduct concentrations and DNA damage of peripheral blood lymphocytes among coke oven workers.Occup Environ Med. 2007 Nov;64(11):753-8.

65. Chen W*, YangJ, Chen J, Bruch J. Exposures to silica mixed dust and cohort mortality study in tin mines:exposure-response analysis and risk assessment of lung cancer. Am J IndMed 2006,49:67-76. 6

66. XingJ, Chen W*, Han W, Guo M, Rehn S, Bruch J. Changes in tumor necrosis factor, surfactant protein A and phospholipids in BAL in miners to develop coal workers’ pneumoconiosis. Biological Medicine and Environmental Science. 2006, 19:124-129.

67. Liu AL, Lu WQ, Wang ZZ, Chen WH, Lu WH, Yuan J, Nan PH, Sun JY, Zou YL, Zhou LH, Zhang C, Wu TC.Elevated levels of urinary 8-hydroxy-2 -deoxyguanosine, lymphocytic micronuclei, and serum glutathione S-transferase in workers exposed to coke oven emissions.Environ Health Perspect. 2006 May;114(5):673-7

68. Chen Y, Bai Y, Yuan J, Chen W, Sun J, Wang H, Liang H, Guo L, Yang X, Tan H, Su Y, Wei Q, Wu T.Association of polymorphisms in AhR, CYP1A1, GSTM1, and GSTT1 genes with levels of DNA damage in peripheral blood lymphocytes among coke-oven workers.Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1703-7

69. Hu Z, Shao M, Yuan J, Xu L, Wang F, Wang Y, Yuan W, Qian J, Ma H, Wang Y, Liu H, Chen W, Yang L, Jin G, Huo X, Chen F, Jin L, Wei Q, Huang W, Lu D, Wu T, Shen H.Polymorphisms in DNA damage binding protein 2 (DDB2) and susceptibility of primary lung cancer in the Chinese: a case-control study.Carcinogenesis. 2006 Jul;27(7):1475-80.

70. Hu Z, Xu L, Shao M, Yuan J, Wang Y, Wang F, Yuan W, Qian J, Ma H, Wang Y, Liu H, Chen W, Yang L, Jing G, Huo X, Chen F, Jin L, Wei Q, Wu T, Lu D, Huang W, Shen H.Polymorphisms in the two helicases ERCC2/XPD and ERCC3/XPB of the transcription factor IIH complex and risk of lung cancer: a case-control analysis in a Chinese population.CancerEpidemiol Biomarkers Prev. 2006 Jul;15(7):1336-40

71. Chen W, Hnizdo E, Chen J-Q, Attfield MD, Gao P, Hearl F, Lu J, Wallace WE. Risk of silicosis in cohorts of Chinese tin and tungsten miners and pottery workers (I): an epidemiological study. Am J Ind Med 2005,48: 1-9.

72. Chen W*, Stempelmann K, Rehn S, Diederichs H, Rehn B, and Bruch J. Biological responses of workplace particles and their association with adverse health effects on miners. J Environ Monit 2004, 6：967-72.

73. Chen W* and Chen J. Nested case control study of lung cancer in four Chinese tin mines. Occup Environ Med 2002; 59:113-118.

74. Chen W*, Zhuang Z, Attfield MD, Chen BT, Gao P, Harrison JC, Fu C, Chen J, and Wallace WE. Exposure to silica and silicosis among tin miners in China: exposure-response analyses and risk assessment. Occup Environ Med 2001,58:31-37.

75. Yang X, Yuan J, Sun J, Wang H, Liang H, Bai Y, Guo L, Tan H, Yang M, Wang J, Su Y, Chen W, Tanguay RM, Wu T. Association between heat-shock protein 70 gene polymorphisms and DNA damage in peripheral blood lymphocytes among coke-oven workers. Mut Res Genet Toxicol Environ Mutag, 2008, 649:221-9

76. Harrison J, Chen J-Q, Miller W, Chen W, Hnizdo E, Lu J, Chisholm W, Keane M, Gao P, Wallace WE. Risk of silicosis in cohorts of Chinese tin and tungsten miners and pottery workers (II): Workplace-specific silica particle surface composition. Am J Ind Med 2005 48: 10-15.

77. Zhuang Z, Heal HJ, Chen W, Chen BT, Chen J, McCawley MA, Gao P, and Soderholm SC. Estimating historical respirable crystalline silica exposures for Chinese pottery workers and iron/copper, tin and tungsten miners. Ann OccupHyg 2001, 45(8):631-642.

78. Gao P, Chen BT, Hearl FJ, Schwerha DJ, Chen W, Chen J, and Soderholm SC. Comparison of three methods to convert Chinese mining dust exposure into respirable fraction. Ann OccupHyg 2000,44(4):251-57.

English Book

1． Chen W,Respiratory Diseases Among Dust Exposed Workers. In Respiratory Diseases (MostafaGhanei), ISBN 978-953-307-964-6. Croatia, InTech, 2012

Presentations (in English)

1． Chen W. Epithelial-Mesenchymal Transition Related Gene mRNAs Transcription and Proteins Expression Regulated by miRNAs in Pneumoconiosis，31st International Congress on Occupational Health. May31- June5, 2015, Seoul, Korea

2． Chen W. Distribution and influence factors for knee and hip injuries among retired workers ofautomotive manufacturing. American Industrial Hygiene Conference & Expo (AIHce) May 30-Jun.4，2015. US.

3． Guo Y, Chen W. Shift work and the relationship with metabolic syndrome in Chinese aged workers. The XX World Congress on Safety andHealth at Work 2014: Global Forum for Prevention. Aug,24-27,2014. Frankfurt, Germany.

4． Chen W，Jiang L, Yu Y, Zhuang Z, Liu Y, Liu J, Yang M. Fitting Characteristics of N95 Filtering-Facepiece Respirators Used Widely in China. American Industrial Hygiene Conference & Expo (AIHce) May 18-23, 2013, Montreal，Canada.

5． Chen W. Long-Term Exposure to Occupational Dust and Major Causes of Death in Chinese Workers. American Industrial Hygiene Conference & Expo (AIHce) May 14-19, 2011, Portland, Oregon, US

6． Liu Y, Chen W. Cardiopulmonary Mortality and Long-Term Exposure to Occupational Dust: a Cohort Study. American Industrial Hygiene Conference & Expo (AIHce) May 14-19, 2011, Portland, Oregon, US

7． Chen W. Long-term exposure to industrial dust and major causes of death in Chinese workers. The 5th International academic conference on environmental and occupational medicine. Apr.7-10, 2010. Chengdu, China

8． Chen W. Head-and-Face Anthropometric Survey and New respirator fit test panels for Chinese Respirator Users. Symposium on Occupational Health Standard by Chinese and German Scientists. June 16-20, 2008. Wuhan, China.

9． Chen W. The study of the characteristics of silicosis in tungsten mines. The International Workshop on Dust Pathogenesis Mechanisms and Prevention Policy-making，Oct 17-19，Beijing，China

10． Chen W. The study of the characteristics and influencing factors of ceramic silicosis. Chinese Conference of Science and Techology, International Conference on Environmental Security and Human HealthSep.9-10,Wuhan,China，Sep.9-10,Wuhan,China

11． Chen W. Epidemiological research of silica dust-exposed workers in Chinese tungsten mines. American Industrial Hygiene Conference & Exposition. Philadelphia, US, Jun 2-7, 2007

12． Chen W, Du L, Zhuang Z. Head-and-Face Anthropometric Survey of Chinese Respirator Users. American Industrial Hygiene Conference & Exposition. Philadelphia, US, Jun 2-7, 2007

13． Chen W.Epidemiological study of dust exposed workers in Chinese metal mines and pottery factories. First International Conference on Frontiers in Biomedical and Environmental Health Sciences: from Molecular and Systems Biology to Human Diseases，Wuhan，China, June 26-30,2006

14． Chen W.Occupational hazards and lung cancer in Chinese workers of dust and PAH exposure. The 62nd eastern forum of science and technology: biomarkers and applications of genotyping technologies on cancer prevention research. Shanghai, China,Sep 8-9,2005.

15． Chen W, Stempelmann K, Rehn S, Diederichs H, Rehn B, and Bruch J. Biological responses of workplace particles and their association with adverse health effects on miners. The tenth international conference on occupational respiratory diseases, Beijing, China, April 19-22,2005.

16． Chen W. Epidemiological research of silica dust exposed workers in Chinese metal mines and pottery industry. International Symposium on Environmental Monitoring and Silica Dust Exposure Assessment. Wuhan, China, April. 14-17, 2005.

17． Chen W, Sun Yi, Bochmann F. Effects of work related confounders on the association between silica exposure and lung cancer – a nested case-control study among Chinese miners and pottery workers. The 2nd China International Forum on Work Safety. Beijing, China, Sep 1-4, 2004.

18． Chen W. Introduction of epidemiological research of Chinese miners and pottery workers. Epidemiological Perspectives on Silica and Health. New York, USA, Aug 5-6, 2004.

19． Chen W, Stempelmann K, Rehn S, Diederichs H, Rehn B, Bruch J. Low dose stimulation of ROS release in AM differentiate particular silica mixed dust from the standard silica: Investigation on workplace dust from Chinese tin mines associated with high mortality of pneumoconiosis and tumor. Oxygen Damage Conference, Morgantown, United States of America, June 6-13, 2002

20． Zhuang Z, Hearl FJ, Chen W, et al.: Estimating historical respirable crystalline silica exposure for Chinese pottery workers and iron/copper, tin and tungsten miners. American Industrial Hygiene Conference & Exposition, Toronto, Canada, June 5-11,1999.

21． Chen W, Zhuang Z, Attfield MA, et al.: Silica exposure and silicosis among tin miners in China: exposure-response analysis and risk assessment. American Industrial Hygiene Conference & Exposition, Atlanta, Georgia, United States of America, May 9-15, 1998.