Dr. Yuan’ research is focused on the following academic fields: environmental health, environmental epidemiology and environmental molecular toxicity.The environmental pollutants including particular matters, BaP, PBDE, DEHP, MEHP, Tris(2-chloroethyl)phosohate (TCEP) and have been investigated in Prof. Yuan’s group. For instance, the modulations of p53-mediated signaling pathway in cell death and/or proliferation induced by POPs using cellular and molecular methods as well as assessment of risk factors for the exposed populations . In the past five years, Dr. Yuan and her team members mainly investigated the regulation mechanisms of p53 and its target effectors in toxicities of multiple air pollutants (BaP, PBDE, DEHP, MEHP) in several cell lines (L02, HepG2, Hep3B, Chang liver cell, Beas-2B, A549, H1299 and MRC-5). The results revealed p53-dependent signaling pathway was dispensable for apoptosis and necrosis induced by these studied pollutants. Additionally, they investigated health effects of major environmental pollutants (such as PAHs, particular matter, heavy metals, …) in urban residentials and populations from a typical E-waste dismantling region and a waste plastic recycling site. They found that the exposure to PBDEs at the e-waste site may have an effect on the levels of TSH and genetoxic damage among the workers who dismantled electronic waste; exposure to background PAHs was related to diabetes among individuals with lower lung function, and urinary levels of OH-PAHs and reduced lung function had an additive effect on diabetes, moreover, several factor (such as urinary OH-PAHs level, passive smoking, self-cooking, ) were found to be associated with subclinical system or organ alterations in the populations. Additionally, Dr.Yuan did her best to make energetic contributions for launching launching urban adult cohort of air pollution and health in Wuhan and Zhuhai cities (the Wuhan-Zhuhai Cohort ), China.

Education

1978-1983　 Bachelor’s Degree of Medicine, School of Public Health,Tongji Medical University, Wuhan, P.R.China

1998-2001　 Master’s Degree of Medicine, School of Public Health,Tongji Medical College of Huazhong University of Science and Technology, Wuhan, P.R.China

2002-2003 　Doctoral Degree of Medicine, Ulm University, Germany

Languages

Chinese, English

Working experience

1983-1987 　Teaching assistant, Department of Statistics, School of Public Health, Sun Yat-Sen University, Guangzhou, P.R.Chian

1987-1992 　Lecturer, Department of Environmental Health, School of Public Health,Tongji Medical University, Wuhan, P.R.China

1992-1994 　Visiting Scholar, Center for Advanced Biotechnology and Medicine, UMDNJ-Robert Wood Johnson Medical School, NJ, USA

1995-1999　 Associate professor, Department of Environmental Health, School of Public Health, Tongji Medical College, HUST, Wuhan, P.R.China

1999.05-1999.09 Visiting Scholar, Charité Campus Virchow-Klinikum, Universitätsmedizin Berlin, Humbold University of D-Berlin, Berlin,Germany

2000-2001 　Associate professor, Department of Environmental Health, School of Public Health, Tongji Medical College, HUST, Wuhan, P.R.China

2002-2003　 Student Scholar, Charité Campus Virchow-Klinikum,Universitätsmedizin Berlin, Humbold University of D-Berlin, Berlin,Germany

2004-2005　Associate professor, Department of Environmental Health, School of Public Health, Tongji Medical College, HUST, Wuhan, P.R.China

2005-present　Professor, Department of Occupatinal and Environmental Health,School of Public Health, Tongji Medical College, HUST, Wuhan, P.R.China

Present Active Research Programs

1. National Natural Science Foundation of China” Roles of Sirtuins in the mitochondrial regulations of TCEP-induced cell damage” (Grant No.81273023).

2. National Natural Science Foundation of China “”Mechanisms of SEC14L3 initiated PI3K/Akt signaling pathways in cellular injury by DEHP and Bap co-exposure”(Grant No. 81472947)

3. The Commonweal Program of National Environmental Protection of the People’s　Republic of China “Pollution characteristics of ambient fine particulate matter in tyical regions and early-warning index system for population health risk”(No. 201409081)

Research interests

• Exposure levels of major environmental pollutants (specially particular matter, PAHs, plasticizer) and their adverse effects on human health

• Toxicological effects of persistent organic pollutants (including BaPs, DEHP, MEHP, TCEP)

Recent publications

1. Zhang W, Zhang Y, Xu T, Wang Z, Wang J, Xiong W, Lu WH, Zheng H, Yuan J*. Involvements of ROS-mediated mitochondrial dysfunction and SIRT3 down-regulation in tris(2-chloroethyl)phosphate-induced cell cycle arrest. Toxicol Res. 2016, 5, 461-470

2. Zhou Y†, Sun H†, Xie J, Song Y, Liu Y, Huang X, Zhou T, Rong Y, Wu T, Yuan J*, Chen W*. Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Altered Lung Function in Wuhan, China. Am J Respir Crit Care Med. 2015 Dec 4. [Epub ahead of print]

3. Hou J†, Sun H†, Xiao L, Zhou Y, Yin WJ, Xu T, Cheng J, Chen W*, Yuan J*. Combined effect of urinary monohydroxylated polycyclic aromatic hydrocarbons and impaired lung function increased risk of diabetes. Envrion Res (Accepted)

4. Hou F†, Huang X†, Liu C†, Sun H, Zhou T, Song Y, Rong Y, Zhu B, Chen W, Wang J, Wang J, He M, Miao X, Hoffmann B, Wu T, Chen W*, Yuan J*. Housing characteristics in relation to exhaled nitric oxide in China. Am J Health Behav. 2015, 39(1):88-98

5. Hou J†, Liu C†, Yao P†, Chen W, He M, Wang Y, Liang Y, Miao X, Wei S, Xu T, Fang W, Zhu J, Li X, Hu FB, Wu T, Yang H*, Yuan J*. Association of Adiposity Indices with Platelet Distribution Width and Mean Platelet Volume in Chinese Adults. PloS One. 2015;10(6):e0129677. doi: 10.1371/journal.pone.0129677.

6. Zhang W, Zhang Y, Wang Z, Xu T, Huang C, Yin W, Wang J, Xiong W, Lu W, Zheng H, Yuan J*. Tris-(2-chloroethyl)-phosphate induced cell growth arrest via attenuation of SIRT1-independent PI3K/Akt/mTOR pathway. J Appl Toxicol. 2015, doi: 10.1002/jat.3223

7. Yang G, Zhang W, Qin Q, Wang J, Zheng H, Xiong W, Yuan J*. Mono(2-ethylhexyl) phthalate induces apoptosis in p53-silenced L02 cells via activation of both mitochondrial and death receptor pathways. Environ Toxicol. 2015, 30(10):1178-91. doi: 10.1002/tox.21990

8. Fang Ye, Xiaoyi Li, Lili Li, Ling Lv, Jing Yuan*, Jun Chen*. The role of Nrf2 in protection against Pb-induced oxidative stress and apoptosis in SH-SY5Y cells. Food Chem Toxicol, 2015, 86:191-201. doi: 10.1016/j.fct.2015.10.009.

9. Feng Y†, Huang X, Sun H, Liu C , Zhang B, Zhang Z, Sharma Tengur V, Chen W, Wu T, Yuan J*, Zhang X*. Framingham risk score modifies the effect of PM10 on heart rate variability. Sci Total Environ. 2015, 523:146-51. doi: 10.1016/j.scitotenv.2015.04.009.

10. Yang G†, Zhang W†, Qin Q, Wang J, Zheng H, Xiong W, Yuan J*. MEHP induced apoptosis in p53-silenced L02 cells via activations of mitochondrial pathway and death receptor pathways. Environ Toxicol. 2015, 30(10):1178-91. doi: 10.1002/tox.21990.

11. Liu C, Yang Y, He M, Yao P, Chen W, Liang Y, Wang Y, Fang W, Zhu J, Li X, Yang H, Yuan J*, Hu FB, Wu T. Passive smoke exposure was related to mean platelet volume in Never-smokers. Am J Health Behav 2014, 38(4):519-528

12. Song Y, Hou J, Huang X, Zhang X, Tan A, Rong Y, Sun H, Zhou Y, Cui X, Yang Y, Guo Y, Zhang Z, Luo X, Zhang B, Hou F, He X, Xie J, Wu T, Chen W*, Yuan J. The Wuhan-Zhuhai (WHZH) cohort study of environmental air particulate matter and the pathogenesis of cardiopulmonary diseases: study design, methods and baseline characteristics of the cohort. BMC Public Health. 2014, 14:994. doi: 10.1186/1471-2458-14-994.

13. Jiang Y†, Chen X†, Yang G, Wang Q, Wang J, Xiong W, Yuan J*. BaP-induced DNA damage initiated p53-independent necroptosis via the mitochondrial pathway involving Bax and Bcl-2. Hum Exp Toxicol. 2013, 32(12):1245-57. doi: 10.1177/0960327113488613

14. Chen X†, Qin Q†, Zhang W, Zhang Y, Zheng H, Liu C, Yang Y, Xiong W, Yuan J*. Activation of the PI3K-AKT-mTOR signaling pathway promotes DEHP-induced Hep3B cell proliferation. Food Chem Toxicol. 2013, 59:325-33. doi: 10.1016/j.fct.2013.06.016.

15. Chen X, Wang J, Qin Q, Jiang Y, Yang G, Rao K, Wang Q, Xiong W, Yuan J*. Mono-2-ethylhexyl phthalate induced loss of mitochondrial membrane potential and activation of Caspase3 in HepG2 cells. Environ Toxicol Pharmacol. 2012, 33(3):421-30. doi: 10.1016/j.etap.2012.02.001.

16. Yang G, Zhou X, Wang J, Zhang W, Zheng H, Lu W, Yuan J*. MEHP-induced oxidative DNA damage and apoptosis in HepG2 cells correlates with p53-mediated mitochondria-dependent signaling pathway. Food Chem Toxicol. 2012, 50(7):2424-31. doi: 10.1016/j.fct.2012.04.023.

Book Editors

1. Preventive Medicine (Editor, Textbook of the national medical colleges and universities in China, for 8-year and 7-year programe medical students). Edition by People Health Publishing House, Beijing, 2015.

2. Molecular Toxicity (Editor-in-Chief, Textbook of the national medical colleges and universities in China, for Master and Ph.D students). Edition by People Health Publishing House, Beijing, 2016 (in press).

3. Preventive Medicine (Associate Editor, Textbook of the national medical colleges and universities in China, for undergraduate nursing students, 4th edition). Edition by People Health Publishing House, Beijing, 2016 (in press).

4. Preventive Medicine (Associate Editor, Textbook of the national medical colleges and universities in China, for undergraduate nursing students, 3rd edition). Edition by People Health Publishing House, Beijing, 2012.