Dr. Liping Hao is Professor of Nutrition and food hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology (HUST). She graduated with a major in Preventive Medicine in 1994 and received her PhD in 2005 from Tongji Medical College. Dr. Hao’s research is mainly focused on: Alcohol intake and health—mechanism of alcohol consumption and the risk of type2 diabetes; The preventive effect of phytochemicals (resveratrol and lutein/zeaxanthin) in chronic metabolic diseases; And also the Iodine nutrition status during pregnancy and its influence on pregnancy outcomes based on the Tongji Maternal and Child Health Cohort Study supported by National Program on Basic Research Project of China. Se has published over 20 original papers (9 of them published in SCI-collected journals including J Nutr Biochem, Diabetes Metab Res Rev, Food Chem Toxicol, PloS One and Lipids).

Education

1989/09-1994/07        Bachelor’s Degree of Medicine

The Faculty of Preventive Medicine

Tongji Medical University

1994/09-1997/07        Master’s Degree of Medicine

Dept. of Environmental Epidemiology

Tongji Medical University

2001/09-2005/07        Doctoral Degree of Medicine

Dept. of Nutrition and Food Hygiene

Tongji Medical College

Languages

Chinese, English, A little German

Work Experience

1997/07-2000/07        Teaching Assistant

Department of Nutrition and Food Hygiene

School of Public Health

Tongji Medical University

2000/07-2005/10        Lector

Department of nutrition and food hygiene,

School of Public Health

Tongji Medical College

Huazhong University of Sciene and Technology

2005/11-2015/10        Associate professor

Department of nutrition and food hygiene,

School of Public Health

Tongji Medical College

Huazhong University of Sciene and Technology

2006/11-2007/11        Post-doctoral fellowship

Clinic for General, Visceral and Transplantation Surgery Charité, Campus Virchow Klinikum

Universitätsmedizin Berlin

Berlin, Germany

2015/11- Present        Professor in Department of nutrition and food hygiene School of Public Health

Tongji Medical College

Huazhong University of Science& Technology

Studies and Previous Research Funding

1. Damage of ethanol on pancreatic islet and the related mechanism reasearch. Supported by the National natural science foundation of China (NNSFC). From 2002/01to 2004/12 (Co-PI)

2. The effect of ethanol on insulin sensitivity and the relationship of ethanol and type 2 diabetes mellitus. Supported by NNSFC. From 2004/01 to 2006/12. (180,000 RMB). (PI)

3. Studies of the main phytochemicals contents in food, population food intakes and the biological health effects. Supported by National Key Technology R&D Program in the 11^th Five year Plan of china. From 2008/12 to 2010/12.

(Co-PI for the sub-topic project, 50,000 RMB)

1. Mechanism of alcohol induced angiogenesis and resveratrol intervention. Sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry. From 2010/01 to 2011/12. (30,000 RMB). (PI)

2. Functional food upgrade to improve the cardiovascular function and osteoporosis. Supported by The National High Technology Research and Development Program of China. Form 2010/01 to 2012/12. (Co-PI for the sub-topic project, 40,000 RMB)

3. Role of SIRT1 in alcohol-induced hepatocyte insulin resistance and resveratrol prevention. supported by ‘the Fundamental Research Funds for the Central Universities’, HUST. From 2011/06 to 2012/12. (120,000 RMB). (PI)

4. Role of SIRT1 in alcohol-induced diabetes mellitus and resveratrol prevention. Supported by NNSFC. From 2012/01 to 2015/12. (600,000 RMB). (PI)

Present Active Research Programs

1. Investigation of Maternal and child health and physical constants. Supported by National Program on Basic Research Project of China. From 2013/06 to 2016/06.  (PI for the sub-topic project, 1,000,000 RMB).

2. Ameliorative effect of lutein on fatty-deposits via lipid mechanism regulation based on SIRT1-associated signaling pathways. Supported by NNSFC. From 2016/01 to 2017/12. (250,000 RMB). (PI)

Career goals

1. Related mechanisms research about the preventive effect of phytochemicals (resveratrol and lutein/zeaxanthin) in chronic metabolic diseases with the techniques of molecular and cellular biology, toxicology, epidemiology and others.

2. Iodine or other micronutrients nutrition status during pregnancy and its influence on pregnancy outcomes in cohort.

3. Nutrients, phytochemicals, genes and their interaction on the prevention the risk of chronic diseases such as diabetes, hypertension or other cardiovascular diseases.

i- Publications in peer-reviewed journals (in English)

1. Peng XL, Xu J, Sun XF, Ying CJ, Hao LP*. Analysis of trans-resveratrol and trans-piceid in vegetable foods using high performance liquid chromatography. Int J Food Sci Nutr. 2015, 66 (7): 729-735.

2. Qiu X, Gao DH, Xiang X, Xiong YF, Zhu TS, Liu LG, Sun XF, Hao LP*.  Ameliorative effects of lutein on non-alcoholic fatty liver disease in rats. World J Gastroenterol. 2015, 21 (26): 8061-8072.

3. Han H, Cui W, Wang L, Xiong Y, Liu L, Sun X, Hao L *. Lutein prevents high fat diet-induced atherosclerosis in apoE-deficient mice by inhibiting NADPH oxidase and increasing PPAR expression. Lipids. 2015, 50 (3): 261-273.

4. Peng XL, Qu W, Wang LZ, Huang BQ, Ying CJ, Sun XF, Hao LP*. Resveratrol Ameliorates High Glucose and High-Fat/Sucrose Diet-Induced Vascular Hyperpermeability Involving Cav-1/eNOS Regulation. PloS One. 2014, 9(11): e113716.

5. Xin P, Han H, Gao D, Cui W, Yang X, Ying C, Sun X, Hao L^*. Alleviative effect of resveratrol on nonalcoholic fatty liver disease are associated with up regulation of hepatic low density lipoprotein receptor and scavenger receptor class B type I gene expression in rats. Food Chem Toxicol. 2013, 52: 12-18.

6. Han H, Xin P, Zhao L, Xu J, Xia Y, Yang X, Sun X, Hao L^*. Excess iodine and high fat diet combination modulates lipid profile, thyroid hormone and hepatic LDLr expression values in mice. Biol Trace Elem Res. 2012, 147(1-3): 233-239.

7. Tang Y, Xu J, Qu W, Peng X, Xin P, Yang X, Ying C, Sun X, Hao L^*. Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase -dependent mechanisms. J Nutr Biochem. 2012, 23(11): 1410-1416.

8. Qu W, Zhao L, Pen X, Yang X, Ying C, Hao L*, Sun X. Biphasic effects of chronic ethanol exposure on insulin-stimulated glucose uptake in primary cultured rat skeletal muscle cells: role of Akt pathway and GLUT4. Diabetes Metab Res Rev. 2011, 27(1): 47-53.

9. Yao P*, Hao L*, Nüssler N, Lehmann A, Song F, Zhao J, Neuhaus P, Liu L, Nussler AK. The protective role of HO-1 and its generated products (CO, Bilirubin and Fe) in ethanol-induced human hepatocyte damage. Am J Physiol Gastrointest Liver Physiol. 2009, 296(6): G1318-1323.  Co-first authors

ii- Abstracts and Presentations( in English)

1. Tang Y, Peng X, Tian C, Zhang C, Ying C, Sun X, Hao L^*. Resveratrol reduces vascular cells senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms. 23rd Scientific Meeting of the International Society of Hypertension (ISH 2010), Vancouver Canada, Sep 26~ 30, 2010. (poster oral presentation)

2. Han H, Cui W, Gao D, Huang B, Liu L, Sun X, Hao L.* Oxygenated carotenoid lutein supplementation against early atherosclerosis in apoE-deficient mice through attenuation of oxidative stress and decrease serum lipid. The 3^rd Cross-Strait Nutrition Conference. Hongkong, Sep. 28-30, 2012.

3. Huang B, Xin P, Han H, Peng X, Sun X, Hao L*. Resveratrol alleviates nonalcoholic fatty liver disease via up regulation of hepatic low density lipoprotein receptor and scavenger receptor class B type I gene expressions in rats. The 3^rd Cross-Strait Nutrition Conference. Hongkong, Sep. 28-30, 2012.

iii- Publications in refereed journals (in Chinese)

1. Hao Liping, Hu Xuefeng, Qu Weng, Zhao Yaowu, Yang Nianhong, Sun Xiufa. A simple method for isolating and purifying the pancreatic islets in rats．Acta Med Univ Sci Technol Huazhong, 2005, 34 (1): 69-71．

2. Hao Liping, Pang Hong, Sun Xiufa, Ying Chenjiang, Yang Nianhong, Mao Limei. Effect of ethanol on insulin secretion  and COXⅡmRNA expression in NIT-1 insulinoma cells．Acta Nutrimenta Sinica, 2005, 27 (4): 317-321.

3. Hao Liping, Hu Xuefeng, Sun Xiufa, Ying Chenjiang, Liu Liegang, Mao Limei. Oxidative damage and apoptosis in NIT-1 cells induced by ethanol. Journal of hygiene research, 2005, 34 (3): 306-308.

4. HAO Li-ping, GUO Jun-qi, ZHOU Shao-liang, CHEN Yi-ying, YING Chen-jiang, SUN Xiu-fa. Effect of chronic ethanol intake on insulin mRNA expression in Rats. ACTA Nutrimenta Sinica, 2006 (10): 394-397.

5. Hao Li-ping, Fan Bolin, Yang Xuefeng, Yao Ping, Yang Nianhong, Mao Limei, Sun Xiufa. Effects of caloric restriction on cognition and behavior in rats, Journal of hygiene research，Journal of hygiene research, 2006 (5): 642-643.

6. Hao Liping, Hu Xuefeng, Qu Wei, Chen Yiying, Zhou Shaoliang, Mao Limei, Sun Xiufa. Effect of ethanol on insulin mRNA expression and function of pancreatic islet β-cells. Chin J Public Health, 2006, 22 (7): 773-775.

7. HAO Li-ping, HU Xue-feng, PANG Hong, QU Wei, YING Chen-jiang, SUN Xiu-fa. The study on apoptosis and its molecular mechanism in mouse insulinoma cells induced by ethanol．J Toxicol, 2006, 20 (3): 138-140.

8. Hao Liping, He Yan, Jiang Zechun, Hu Fengxian, Zhu Qinghua. Effect of cooking on vitamin B group in pasta. Central China Medical Journal, 2000, 24 (3): 119-120.

9. Hao Liping, Zhou Yunzhen, Li Jing, Yang Xuefeng. Bovine colostrum ameliorates infectious diseases in infants and toddlers. Chinese Journal of Social Medicine, 2012, 20 (1): 68-70.

10. Liu Zhao, Tian Liyue, He Qingyi, Yao Ping, Yang Xuefeng, Ying Chenjiang, Hao Liping*, Sun Xiufa. Analysis of medical students nutrients intake and the related influence factors. Chin J Public Health, 2008, 24 (suppl.): 5-7.

11. Tian Liyue, Zhao Lina, Qu Wei, Hao Liping*, Ying Chenjiang, Sun Xiufa. Influence of chronic alcohol intake with high fat diet on the key Molecules of insulin signal transduction in liver of rats. ACTA Nutrimenta Sinica, 2010, 32 (2): 109-112.

12. Tang Yuhan, Xin Peng, Hao Liping*, Yao Ping, Liu Liegang, Sun Xiufa. Protection of resveratrol on up-regulated Ho-1 against ethanol-induced hepatotoxicity. ACTA Nutrimenta Sinica, 2011, 33 (1): 49-51, 55.

13. Xu Shan, Wang Changyi, Zhang Chunhui, Liu Shengyuan, Peng Xiaolin, Chen Zhongwei, Hao Liping*. Comparison of high uric acid hematic disease prevalence among ordinary high blood pressure patients, hypertension patients with high homocysteine levels, and healthy people. South China J Prev Med, 2014, 40 (6): 563-565.

14. Huang Bingqing, Qiu Xiang, Wang Linzhi, Zhu Tengshi, Guo Yanfang, Hao Liping*. Resveratrol protects against chronic alcoholic liver by regulating hepatic ALDH2 expression in rats. Acta Med Univ Sci Technol Huazhong, 2015, 44 (1): 37-41.