Education

MD ,1982,Tongji Medical University ,China

Ph D. ,1988,Tonji Medical University,Chian

Other Affiliations

Research

Dr Shi ‘s major research interesta include:
1. Effects of the Neuroendocrine systemon the neurotoxicity of Pyrethroids.

2. Chemoprotection against chemical toxicity &diseases.

Publications

1) Effects of pyrethroids on the concentrations of thyroid hormones in the rat serum and brain Chin J Hyg Occup Dis 2002, 20(3):173-176 (Wang Suqing)

2) Increased levels of nerve growth factor mRNA and protein expression in rat brain induced by pyrethroids Chinese J Pharmacl. & Toxicol 2002,16(4):306-311(Wang Suqing)

3) Effects of pyrethroids on monoamine levels in rat brain J Health Toxicology 2001,15(2):78-80 (Cai Hongmei)

4) Effect of deltamethrin on neurobehavioral development of offsprings of intoxicated rats Chin J Hyg Occup Dis 2001,19(4):268-270 (Li Tao)

5) Effect of deltamethrin on intracellular free Ca2+ concentration in rat neural cells J Health Toxicology 2001,15(4):216-219 (Niu yujie)

6) Effect of pyrethroids on the binding metabotropic glutamate receptor in rat brain Chin J Hyg Occp Dis 2000,18(4):220-222 (Yan hong)

7) Effects of pyrethroids on metabolizing enzymes in rat brain and liver Chin J Ind Hyg Occp Dis 2000,18(4):216-219 (Yi zongchun)

8) Liu gong-ping ,Nian Shi, The inhibitory effects of deltamethrin on dopamine biosynthesis in rat PC12 cells, Toxicology Letters,161,195-199(2006)

9) Huang-yuan Li, Si-ying Wu, Nian Shi, Transcription factor Nrf2 activation by deltamethrin in PC12 cells: Involvement of ROS, Toxicology Letters 2007,107:87-98

10) Dan Chen,Xiaowei Huang,Linlin liu and Shi Nian, Deltamethrin induces mitochondrial membrane permeability and altered expression of cytochrome C in rat brain, J of Applied Toxicology 2007,27；368－372

11) Huang-yuan Li ,Yu-fang Zhong, Si-ying Wu, Nian Shi,EF-E2 Related Factor 2 Activation and Heme Oxygenase -1 Induction by tert-Butylhydroquinone Protect against Deltamethrin-Mediated Oxidative Stress in PC12 Cells, Chem. Res. Toxicol, 2007,20 ,1242-1251

12) Yuan-feng Li,Tao Li ,Mei-zhu Zhuang,Kai-liang Wang ,Juan Zhang,Nian Shi, High-dose dibutyl phthalate improves performance of F1 generation male rats in spatial learning and increases hippocampal BDNF expression independent on p-CREB immunocontent, Environmental， Toxicology and Pharmacology , 2010,29:32-38

13) Li H, Wu S, Shi N, Lian S, Lin W，Nrf2/HO-1 pathway activation by manganese is associated with reactive oxygen species and ubiquitin-proteasome pathway, not MAPKs signaling J Appl Toxicol. 2011；31（7）：690－697

14) HY Li、SY Wu、Q Ma、and N Shi The pesticide deltamethrin increases free radical production and promotes nuclear translocation of the stress response transcription factor Nrf2 in rat brain ，Toxicology and industrial health ,2011，27（7）：579－590

15）Huangyuan Li, Siying Wu, and Nian Shi, Effect of Glutathione Depletion on NRF2/ARE Activation by Deltamethrin in PC12 Cells, Archives of Industrial Hygiene and Toxicology 2013;64（1）:87-97

16）Yan Qing ,Nian Shi,et al Apoptosis induced by Trimethyltin chloride in human neuroblastoma cells SY5Y is regulated by a balance and cross-talk between NF-κB and MAPKs signaling pathways , Archives of Toxicology: Volume 87, Issue 7 (2013), Page 1273-1285