工作及教育经历

2015.5-至今  华中科技大学同济医学院公共卫生学院营养与食品卫生学系 讲师 副教授

2013.7-2015.7 华中科技大学同济医学院公共卫生学院营养与食品卫生学师资博士后

2010.9-2013.7 华中科技大学同济医学院公共卫生学院营养与食品卫生学专业硕博连读

2008.9-2010.7  华中科技大学同济医学院公共卫生学院营养与食品卫生学专业攻读硕士学位

2003.9-2008.7  大理医学院公共卫生学院预防医学专业攻读学士学位

主要研究方向和兴趣

主要研究方向为膳食、营养与慢性病。近五年以第一作者或通讯作者发表SCI文章10余篇。 主要研究内容及成果如下：1.白藜芦醇的生物学效应及其抗衰老效应，研究结果发现白藜芦醇能有效延缓血管衰老的发生，研究结果发表在JNB，被引近50次；2. 研究酒精对肝脏的氧化损伤机制，重点探讨植物黄酮尤其是槲皮素对酒精性肝病(ALD)的干预，以及潜在分子信号通路。新近以铁稳态调控分子hepcidin为中心，探讨酒精致铁代谢紊乱的分子机制。此外，获湖北省自然科学技术奖二等奖（3/5）1项“植物黄酮诱导HO-1拮抗酒精性肝病的机制”。中国营养学会社区营养与健康管理分会委员，湖北省营养学会理事，武汉营养学会秘书长。

主要负责的科研项目

1.食品安全大数据智能应用技术研究 （子课题负责人）（2018年国家重点研发计划，项目编号：2018YFC1604003）

2.Rab7介导的线粒体自噬和外泌体在酒精性肝铁过载的协同机制及槲皮素干预研究（国家自然科学基金面上项目，项目编号：81872619）

3.应用蛋白质组学分析Frataxin缺失对酒精性肝线粒体自噬的作用及其机制（湖北省自然科学基金面上项目，项目编号：2018CFB480）

4.FOXO3-Frataxin介导的肝脏线粒体酒精性损伤及槲皮素干预机制 （国家自然青年科学基金，项目编号：81402673）；

5.ALD中Parkin和受体介导的线粒体自噬失衡及槲皮素干预 （第56批中国博士后基金：130324）。

论文发表情况

1.Lin Xiao, Gang Luo, Yuhan Tang*, Ping Yao*, Quercetin and iron metabolism: What we know and what we need to know, Food and chemical toxicology, 2018, 114: 190~203.

2.Xinhong Zhu, Ting Xiong, Peiyi Liu, Xiaoping Guo, Lin Xiao, Feng Zhou,  Yuhan Tang*, Ping Yao*, Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway, Food and chemical toxicology, 2018.2.10, 114: 52~60.

3.Liu P,Lin H, Xu Y,Zhou F,Wang J, Liu J, Zhu X,Guo X,Tang Y*,YaoP* Frataxin-Mediated PINK1-Parkin-Dependent Mitophagy in Hepatic Steatosis: The Protective Effects of Quercetin. Molecular Nutrition &Food Research, 2018, 2018, 62(16):e1800164.

4.Xiao L, Liu L, Guo X, Zhang S, Wang J, Zhou F, Liu L, Tang Y*, Yao P*. Quercetin attenuates high fat diet-induced atherosclerosis in apolipoprotein E knockout mice: A critical role of NADPH oxidase.Food Chem Toxicol. 2017 Jul;105:22-33. doi: 10.1016/j.fct.2017.03.048.

5.Tang Y#, Li J, Gao C, Xu Y, Li Y, Yu X, Wang J, Liu L, Yao P*.Hepatoprotective Effect of Quercetin on Endoplasmic Reticulum Stress and Inflammation after Intense Exercise in Mice through Phosphoinositide 3-Kinase and Nuclear Factor-Kappa B. Oxid Med Cell Longev. 2016;2016:8696587. doi: 10.1155/2016/8696587.

6.Yu X, Xu Y, Zhang S, Sun J, Liu P, Xiao L, Tang Y*, Liu L, Yao P*. Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damage through Enhanced Mitophagy. Nutrients. 2016 Jan 5;8(1). pii: E27. doi: 10.3390/nu8010027.

7.Li Y, Chen M, Xu Y, Yu X, Xiong T, Du M, Sun J, Liu L, Tang Y*, Yao P*. Iron-mediated Lysosomal Membrane Permeabilization in Ethanol Induced Hepatic Oxidative Damage and Apoptosis: Protective Effects of Quercetin. Oxidative Medicine and Cellular Longevity, 2016, doi.org/10.1155/2016/4147610.

8.Tang YH#, Li YY, Yu HY, Gao C, Liu L, Chen SD, Xing MY, Liu LG, Yao P*. Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway, J Nutr Biochem. 2014, 25(6):675-82.

9.Tang YH#, Li YY, Yu HY, Gao C, Liu L, Xing MY, Liu LG, Yao P*. Quercetin attenuates chronic ethanol hepatotoxicity: implication of “free” iron uptake and release. Food Chem Toxicol. 2014, 67:131-8.

10.Tang YH#, Gao C, Shi YR, Zhu LP, Hu XM, Wang D, Yang L, Yang XF, Liu LG, Yao P*. Quercetin attenuates ethanol-derived microsomal oxidative stress: Implication of haem oxygenase-1 induction, Food Chemistry, 132(4): 1769-1774, 2012.

11.Tang YH#, Xu J, Qu W, Peng XL, Xin P, Yang XF, Ying CJ, Sun XF, Hao LP*. Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase -dependent mechanisms, J Nutr Biochem, 23(11): 1410-1416, 2012.

12.Tang YH#, Gao C#, Xing MY, Li YY, Zhu LP, Wang D, Yang XF, Liu LG, Yao P*. Quercetin prevents ethanol-induced dyslipidemia and mitochondrial oxidative stress, Food Chemical Toxicology, 50(5): 1194-1200, 2012.

13.Tang YH#, Tian H#, Shi YR, Gao C, Xing MY, Yang W, Bao W, Wang D, Liu LG, Yao P*. Quercetin suppressed CYP2E1-dependent ethanol hepatotoxicity via depleting heme pool and releasing CO, Phytomedicine, 20(8): 699-704, 2013.

14.Gao C, Chen X, Li J, Li Y, Tang Y, Liu L, Chen S, Yu H, Liu L, Yao P.Myocardial mitochondrial oxidative stress and dysfunction in intense exercise: regulatory effects of quercetin.Eur J Appl Physiol. 2014 Apr;114(4):695-705.

15.Li Y, Gao C, Shi Y, Tang Y, Liu L, Xiong T, Du M, Xing M, Liu L, Yao P. Carbon monoxide alleviates ethanol-induced oxidative damage and inflammatory stress through activating p38 MAPK pathway. Toxicol Appl Pharmacol. 2013 Nov 15;273(1):53-8.

16.Jie Q, Tang Y, Deng Y, Li Y, Shi Y, Gao C, Xing M, Wang D, Liu L, Yao P.Bilirubin participates in protecting of heme oxygenase-1 induction by quercetin against ethanol hepatotoxicity in cultured rat hepatocytes. Alcohol. 2013 Mar;47(2):141-8.

17.Liu L, Tang Y, Gao C, Li Y, Chen S, Xiong T, Li J, Du M, Gong Z, Chen H, Liu L, Yao P.Characterization and biodistribution in vivo of quercetin-loaded cationic nanostructured lipid carriers. Colloids Surf B Biointerfaces. 2014 Mar 1;115:125-31.

18.唐玉涵#等. 白藜芦醇诱导HO-1对酒精性肝细胞的保护作用. 营养学报，2011，3（1）： 49-53.