教授, 博士生导师
一、主持科研项目（课题）情况（按时间倒序排序）:
1. 国家自然科学基金面上项目，82473626，槲皮素靶向SOD1调控氧化应激驱动的肾小管上皮细胞衰老改善糖尿病肾病的研究，2025/01-2028/12，49万，在研，主持
2. 2024年国家重点研发计划，2024YFF1106204，功能蛋对不同营养特需人群的干预作用及蛋品健康功效数据库构建（子课题），2024/12-2027/12，70万，在研，主持。
3. 湖北省自然科学基金创新发展联合基金重点项目，肠道菌群在酵母β-葡聚糖改善衰老相关认知障碍中的作用及机制研究，2024/03-2027/02，20万，在研，主持。
4. 武汉市科技局专项，2020020601012246，衰老细胞启动细胞竞争诱导凋亡在糖尿病肾病中的作用及榭皮素干预，2020/08-2022/12，50万，结题，主持。
5. 国家自然科学基金面上项目，81872619，Rab7介导的线粒体自噬和外泌体在酒精性肝铁过载的协同机制及槲皮素干预研究，2019/01-2022/12，57万，结题，主持。
6. 2018年国家重点研发计划，2018YFC1604003，食品安全大数据关键技术研究课题“食品安全大数据智能应用技术研究”，2018/12-2021/12，30万，结题，子课题负责人。
7. 安琪营养基金科研项目资助，20191685，布拉氏酵母对儿童急性腹泻的随机双盲安慰剂对照临床研究，2019/7-2021/7，40万，在研，主持。
8. 湖北省自然科学基金面上项目，2018CFB480，应用蛋白质组学分析Frataxin缺失对酒精性肝线粒体自噬的作用及其机制，2018/01-2019/12，结题，主持。
9. 国家自然科学基金委员会，青年基金，81402673，FOXO3-Frataxin介导的肝脏线粒体酒精性损伤及槲皮素干预机制，2015/01-2017/12，结题，主持。
10. 中国博士后科学基金，第56批中国博士后基金面上项目，130324，ALD中Parkin和受体介导的线粒体自噬失衡及槲皮素干预，2014/01-2015/12，结题,主持。
二、以第一作者或通讯作者身份发表的代表性论著
(1) Li Chen, Bangfu Wu, Li Mo, Huimin Chen, Xingzhu Yin, Ying Zhao, ZhaoYu Cui, Feipeng Cui, Liangkai Chen, Qianchun Deng, Chao Gao, Ping Yao, Yanyan Li, and Yuhan Tang*. High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan. Nature Communications. 2025.
(2) Huimin Chen, Chao Gao, Li Mo, Xingzhu Yin, Li Chen, Bangfu Wu, Ying Zhao, Xueer Cheng, Chanhua Liang, Bichao Xu , Dongyan Li, Yanyan Li, Ping Yao, Yuhan Tang*. Interleukin 33 promotes liver sinusoidal endothelial cell dysfunction and hepatic fibrosis in diabetic mice. Diabetes & Metabolism Journal. 2025.
(3) Li Chen, Chao Gao, Xingzhu Yin, Li Mo, Xueer Cheng, Huimin Chen, Chunjie Jiang, Bangfu Wu, Ying Zhao, Hongxia Li, Yanyan Li, Jiansha Li, Liangkai Chen, Qianchun Deng, Ping Yao, Yuhan Tang*. Partial reduction of interleukin-33 signaling improves senescence and renal injury in diabetic nephropathy. MedComm (2020). 2024 Oct 24;5(11):e742.(IF=10.7)
(4) Li Chen, Bangfu Wu, Li Mo, Huimin Chen, Ying Zhao, Tianqi Tan, Liangkai Chen, Yanyan Li, Ping Yao, Yuhan Tang*. Associations between biological ageing and the risk of, genetic susceptibility to, and life expectancy associated with rheumatoid arthritis: a secondary analysis of two observational studies. Lancet Healthy Longev. 2023 8:S2666-7568(23)00220-9. (IF=13.4)
(5) Li Chen, Ying Zhao, Fangqu Liu, Huimin Chen, Tianqi Tan, Ping Yao, Yuhan Tang*. Biological aging mediates the associations between urinary metals and osteoarthritis among U.S. adults. BMC Med. 2022, 20(1): 207.( IF=11.81)
(6) Zhuangyu Zhang, Fangqu Liu, Xingzhu Yin, Bangfu Wu, Hongxia Li, Fei Peng, Maowei Cheng, Jingjing Li, Jingjing Xiang, Ping Yao, Shuang Liu, Yuhan Tang*. Chinese Healthy Eating Index (CHEI) and risk of diabetes in Chinese adults: a prospective cohort study. Eur J Nutr. 2024, 63(3): 939-949. (IF=5.0)
(7) Jingjing Liu, Huimin Chen, Hongkun Lin, Shufen Peng, Li Chen, Xueer Cheng, Ping Yao,Yuhan Tang* Iron-frataxin involved in the protective effect of quercetin against alcohol-induced liver mitochondrial dysfunction. J Nutr Biochem. 2023, 114: 109258. (IF=5.6)
(8) Xueer Cheng, Yanyan Li, Li Chen, Chunjie Jiang, Shufen Peng, Ping Yao, Yuhan Tang*. Excess iron accumulation mediated senescence in diabetic kidney injury. J Biochem Mol Toxicol. 2024, 38(4): e23683. (IF=3.6)
(9) Huimin Chen, Jingjing Liu, Shufen Peng, Guang Yang, Xueer Cheng, Li Chen, Han Zhang, Ying Zhao, Ping Yao, Yuhan Tang. Autophagy and exosomes coordinately mediate quercetin’s protective effects on alcoholic liver disease. J Nutr Biochem. J Nutr Biochem. 2023, doi: 10.1016/j.jnutbio.2023.109332. (IF=5.6)
(10) Huimin Chen, Yuhan Tang. Iron-loaded Extracellular Vesicles: Angel or Demon? Free Radical Res. 2023, doi: 10.1080/10715762.2023.2191813. (IF=3.3, )
(11) Li Chen, Xingzhu Yin, Ying Zhao, Huimin Chen, Tianqi Tan, Ping Yao, Yuhan Tang*. Biological ageing and the risks of all-cause and cause-specific mortality among people with diabetes: a prospective cohort study. J Epidemiol Community Health. 2022, doi: 10.1136/jech-2022-219142. (IF=6.3)
(12) Chen L, Sun Q, Peng S, Tan T, Mei G, Chen H, Zhao Y, Yao P, Tang Y*. Associations of blood and urinary heavy metals with rheumatoid arthritis risk among adults in NHANES, 1999-2018. Chemosphere. 2022, 289:133147. (IF=8.9)
(13) Shufen Peng, Huimin Chen, Li Chen, Guang Yang, Jingjing Liu, Xueer Cheng, Yuhan Tang*. Beyond Isocitrate Dehydrogenase Mutations: Emerging Mechanisms for the Accumulation of the Oncometabolite 2-Hydroxyglutarate. Chem Res Toxicol. 2022,35(2):115-124. (IF=4.1)
(14) Lin Xiao, Gang Luo, Hongxia Li, Ping Yao*, Yuhan Tang*. Dietary iron overload mitigates atherosclerosis in high-fat diet-fed apolipoprotein E knockout mice: Role of dysregulated hepatic fatty acid metabolism. BBA- Mol Cell Biol L. 2021,1866(10):159004. (IF=4.8)
(15) Li Chen, Jing Liu, Guibin Mei, Huimin Chen, S Peng, Ying Zhao, Ping Yao, Yuhan Tang*. Quercetin and non-alcoholic fatty liver disease: A review based on experimental data and bioinformatic analysis. Food Chem Toxicol. 2021, 154:112314. (IF=5.5)
(16) Hongxia Li, Lin Xiao, Hui He, Hongmei Zeng, Jingjing Liu, Chunjie Jiang, Guibin Mei, Jiasheng Yu, Hao Chen, Ping Yao*, Yuhan Tang*. Quercetin Attenuates Atherosclerotic Inflammation by Inhibiting Galectin-3-NLRP3 Signaling Pathway. Mol Nutr & Food Res. 2021, 65(15):e2000746. (IF=6.5)
(17) Li Chen, Guibin Mei, Chunjie Jiang, Xueer Cheng, Dan Li, Ying Zhao, Hunmin Chen, C Wan, Ping Yao, Chao Gao*, Yuhan Tang*. Carbon monoxide alleviates senescence in diabetic nephropathy by improving autophagy. Cell Prolif. 2021, 54(6):e13052. (IF=8.7)
(18) Jingjing Liu, Hui He, Jing Wang, Xiaoping Guo, Hongkun Lin, Huimin Chen, Chunjie Jiang, Li Chen, Ping Yao*, Yuhan Tang*, Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis, Toxicology, 2020, 445: 152584. (IF=4.2)
(19) Chao Gao, Yang Liu, Chunjie Jiang, Liang Liu, Juan Li, Dan Li, Xiaoping Guo, Zhu Wang, Yuexin Yang, Liegang Liu, Ping Yao, Yuhan Tang*. Intensive Running Enhances NF-κB Activity in the Mice Liver and the Intervention Effects of Quercetin, Nutrients, 2020, 12:2770. (IF=5.7)
(20) Xinhong Zhu, Ting Xiong, Peiyi Liu, Xiaoping Guo, Lin Xiao, Feng Zhou, YuhanTang*. Ping Yao*. Quercetin ameliorates HFD-induced NAFLD bypromotinghepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway, Food Chem Toxicol, 2018, 114: 52-60.
(21) Lin Xiao, Gang Luo, Yuhan Tang*, Ping Yao*. Quercetin and ironmetabolism: What we know and what we need to know, Food Chem Toxicol, 2018, 114: 190-203.
(22) Peiyi Liu, Hongkun Lin, Yanyan Xu, Feng Zhou, Jing Wang, Jingjing Liu,Xinhong Zhu, Xiaoping Guo, YuhanTang*. Ping Yao*. Frataxin-Mediated PINK1-Parkin-Dependent Mitophagy in Hepatic Steatosis: The Protective Effects of Quercetin, Mol Nutr &Food Res, 2018,62(16):e1800164.
(23)Yanyan Li, Chen M, YanyanXu, Xiao Yu, Ting Xiong, Min Du, Jian Sun, LiegangLiu, YuhanTang*, Ping Yao*. Iron-mediated Lysosomal Membrane Permeabilization in Ethanol Induced Hepatic Oxidative Damage and Apoptosis: Protective Effects of Quercetin, Oxid Med Cell Longev, 2016, 2016: 4147610.
(24) Lin Xiao, Liang Liu, Xiaoping Guo, Shanshan Zhang, Jing Wang, Feng Zhou, LiegangLiu, YuhanTang*, Yao P*. Quercetin attenuates high fat diet-induced atherosclerosis inapolipoprotein Eknockout mice: A critical role of NADPH oxidase, Food Chem Toxicol, 2017, 105: 22-23.
(25) YuhanTang#, YanyanLi, Haiyan Yu, Chao Gao, Liang Liu, Shaodan Chen, Mingyou Xing, Liegang Liu, Ping Yao*. Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway, J Nutr Biochem,2014, 25(6):675-82.
(26) YuhanTang, Juan Li, Chao Gao, YanyanXu, YanyanLi, Xiao Yu, Jing Wang, LiegangLiu, Ping Yao*. Hepatoprotective Effect of Quercetin on Endoplasmic Reticulum Stress andInflammation after Intense Exercise in Mice through Phosphoinositide 3-Kinaseand Nuclear Factor-Kappa B, Oxid Med Cell Longev, 2016,2016:8696587.
(27) Xiao Yu, YanyanXu, Shanshan Zhang, Jian Sun, PeiyiLiu, Lin Xiao, YuhanTang*, LiegangLiu, Ping Yao*. Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damagethrough Enhanced Mitophagy,Nutrients, 2016, 8(1): 27.
(28) YuhanTang,YanyanLi, Haiyan Yu, Chao Gao, Liang Liu, MingyouXing, LiegangLiu, Ping Yao*. Quercetin attenuates chronic ethanol hepatotoxicity: implication of “free” iron uptake and release, Food Chem Toxicol, 2014, 67: 131-138.
(29) YuhanTang#, HongtaoTian#, YanruShi, Chao Gao, MingyouXing,Wei Yang, Wei Bao, Di Wang, LiegangLiu, Ping Yao*, Quercetin suppressed CYP2E1-dependent ethanol hepatotoxicity viadepleting heme pool and releasing CO,Phytomedicine, 2013, 20(8-9):699-704.
(30) YuhanTang#, Chao Gao#, MingyouXing, YanyanLi, LipingZhu, Di Wang, XuefengYang, LiegangLiu, Ping Yao*, Quercetin prevents ethanol-induced dyslipidemia and mitochondrialoxidative damage, Food Chem Toxicol, 2012, 50(5):1194-1200.
(31) YuhanTang, Chao Gao, YanruShi, LipingZhu, Hu XM, Di Wang, Liu Yang, XuefengYang, LiegangLiu, Ping Yao*, Quercetin attenuates ethanol-derived microsomal oxidative stress: Implication of haem oxygenase-1 induction,Food Chem, 2012,132(4):1769-1774.
(32) YuhanTang#, Jian Xu, Wei Qu, Xiaolin Peng, Peng Xin, Xuefeng Yang, Chenjiang Ying, XiufaSun, Liping Hao*, Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms, J Nutr Biochem, 2012, 23(11): 1410-1416.
三、参编教材或专著
1. 社区营养与健康管理，人民卫生出版社、124-136页，2020年12月，编委。
2. 真菌毒素污染与健康，湖北科技出版社、1-24，2021年12月，副主编。
3. 临床营养学（“十一五”国家级规划教材第四版），科学技术出版社，2025年1月，编委兼秘书
四、获奖或社会服务
1. 中国营养学会社区营养与健康管理分会常务委员
2. 中国学生营养与健康促进会大学生健康分会副秘书长
3. 中华预防医学营养与健康分会委员
4. 中国科学技术协会科普专家
5. 湖北省国民营养健康专家委员会委员
6. 武汉营养学会秘书长
7. 唐玉涵(3/5); 植物黄铜诱导HO-1拮抗酒精性肝病的机制, 湖北省人民政府, 自然科学, 省部二等奖, 2014(刘烈刚;姚平;唐玉涵; 郝丽萍; 杨雪锋)。
8. 《中小学生食品安全知识读本丛书》获得中国营养科学技术进步奖二等奖。
9. 教育部首批一流本科课程《食源性疾病现场调查与处理》
