2007年毕业于华中科技大学预防医学专业，2012年在华中科技大学同济医学院获医学博士学位。2016.1-2017.12在哈佛大学医学院Dana-Farber Cancer Institute及哈佛大学公共卫生学院做博士后研究。主要研究方向：营养流行病学、肿瘤流行病学，重点关注饮食、菌群、免疫在结直肠癌发生发展中的作用。承担了国家自然科学基金、湖北省卫生健康委预防转项-重点项目、中国科协、教育部博士点课题等多项项目，作为课题骨干参与了国家重点研发项目、湖北省技术创新专项重大项目、国家自然基金重点项目等。以第一作者或通讯作者在JAMA、Gastroenterology、Gut、Cell Host Microbe、Clin Gastroenterol Hepatol、Eur J Epidemiol等杂志上发表论文。获得湖北省科技进步二等奖，中国抗癌协会科技奖二等奖。

主要承担的科研项目

2014-2016  全基因组表达相关拷贝数变异在结直肠癌发生发展中的作用及机制研究，国家自然基金青年基金

2014-2016  全基因组表达相关拷贝数变异在结直肠癌易感性中的作用，教育部博士点课题

2019-2020  粪便微生物检测在结直肠肿瘤早期筛查及预后预测中的价值，湖北省卫生计生科研项目青年人才项目

2022-2025 炎性膳食模式、淋巴细胞浸润相关遗传变异及其交互作用与结直肠癌风险的关联及机制研究，国家自然基金面上项目

2025-2028 具核梭杆菌、肿瘤抑制基因甲基化数量性状位点及其交互与结直肠癌

风险的关联及机制研究，国家自然基金面上项目

主要参与的科研项目

2019-2021 结直肠癌及乳腺癌精准预防和预后评估的关键技术研发 湖北省技术创新专项重大项目

2020-2021 新冠肺炎随访队列研究  国家重点研发项目

2020-2023 遗传负荷及生活方式评分对结直肠癌发病及预后风险预测的前瞻性研究，国家自然基金面上项目 (81974491)

2025-2029 胃癌癌前病变风险评估和早期干预研究 （2025ZD0545300）

代表性论著

1. Yang S, Lu H, Jin M, Pei W, Wang Z, Ni J, Shi Y, Zhang S, Li Y, Li C, Sun H, Jia X, Deng H, Liu H, Liu L. Oat-β-glucan potentiates anti-PD-1 efficacy through Faecalibacterium prausnitzii-derived butyrate and indole-3-propionic acid. Cell Host Microbe. 2026 May 29:S1931-3128(26)00178-2. doi: 10.1016/j.chom.2026.05.002.

2. Li Y, Jia X, Li C, Sun H, Nie S, Giovannucci EL, Liu L. The global incident gastrointestinal cancers attributable to suboptimal diets from 1990 to 2018. Gastroenterology. 2024 Nov;167(6):1141-1151.

3. Ugai S, Liu L, Kosumi K, Kawamura H, Hamada T, Mima K, Arima K, Okadome K, Yao Q, Matsuda K, Zhong Y, Mizuno H, Chan AT, Garrett WS, Song M, Giannakis M, Giovannucci EL, Zhang X, Ogino S, Ugai T. Long-term yogurt intake and colorectal cancer incidence subclassified by Bifidobacterium abundance in tumor. Gut Microbes. 2025 Dec;17(1):2452237. (Co-first author)

4. Wang Z, Zhang J, Lu H, Ni J, Yang S, Shi Y, Zhang S, Zhang P, Liu L. Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP-Mediated Invasion Activates Ras Signaling and Destabilizes p53. Adv Sci (Weinh). 2026 Apr 7:e17245. doi: 10.1002/advs.202517245.

5. Chen W, Zhao Y, Lu H, Yi J, Li J, Song X, Zhang J, Yang S, Ni J, Wang Z, Shi Y, Ni Y, Zhang Z, Zhu S, Nie S, Liu L. Associations of dietary patterns with risk of gastrointestinal disorders: a prospective cohort study. Food Funct. 2024 Aug 12;15(16):8510-8520.

6. Pei W, Li J, Lei S, Nie S, Liu L. Burden of major cancers in China attributable to modifiable risk factors: Predictions from 2012 to 2035. Int J Cancer. 2025 Apr 1;156(7):1369-1379.

7. Ni J, Lu H, Chen W, Zhao Y, Yang S, Zhang J, Wang Z, Shi Y, Yi J, Li J, Song X, Ni Y, Zhu S, Zhang Z, Liu L. Plasma metabolite profiles related to dietary patterns: exploring the association with colorectal tumor risk. Eur J Nutr. 2024 Nov 21;64(1):13.

8. Zhao Y, Wang Q, Chen W, Li J, Yi J, Song X, Ni Y, Zhu S, Zhang Z, Nie S, Liu L. Associations of ultraprocessed food consumption with mortality among participants with a history of cancer: a prospective cohort analysis. Am J Clin Nutr. 2024 Sep;120(3):471-480.

9. Huang H, Zhao Y, Yi J, Chen W, Li J, Song X, Ni Y, Zhu S, Zhang Z, Xia L, Zhang J, Yang S, Ni J, Lu H, Wang Z, Nie S, Liu L. Post-diagnostic lifestyle and mortality of cancer survivors: Results from a prospective cohort study. Prev Med. 2024 May 29:185:108021.

10. Li J, Song X, Ni Y, Zhu S, Chen W, Zhao Y, Yi J, Xia L, Nie S, Shang Q, Liu L. Time trends of 16 modifiable risk factors on the burden of major cancers among the Chinese population. Int J Cancer. 2024 Apr 15;154(8):1443-1454.

11. Zhao Y, Chen W, Li J, Yi J, Song X, Ni Y, Zhu S, Zhang Z, Xia L, Zhang J, Yang S, Ni J, Lu H, Wang Z, Nie S, Liu L. Ultra-Processed Food Consumption and Mortality: Three Cohort Studies in the United States and United Kingdom. Am J Prev Med. 2024 Feb;66(2):315-323.

12. Song X, Feng X, Chen S, Dai Y, Huang H, Li X, Yu P, Li J, Yi J, Zhao Y, Chen W, Ni Y, Zhu S, Zhang Z, Xia L, Zhang J, Yang S, Ni J, Lu H, Wang Z, Nie S, Wu Y, Liu L. Potential impact of time trend of whole grain intake on burden of major cancers in China. Prev Med. 2023 Oct:175:107674.

13. Yang T, Yi J, He Y, Zhang J, Li X, Ke S, Xia L, Liu L. Associations of Dietary Fats with All-Cause Mortality and Cardiovascular Disease Mortality among Patients with Cardiometabolic Disease. Nutrients. 2022 Aug 31;14(17):3608.

14. Pan A, Liu L, Wang C, Guo H, Hao X, Wang Q, Huang J, He N, Yu H, Lin X, Wei S, Wu T. Association of Public Health Interventions With the Epidemiology of the COVID-19 Outbreak in Wuhan, China. JAMA. 2020 Apr 10;323(19):1-9. (Co-first author)

15. Kosumi K, Hamada T, Zhang S, Liu L, da Silva A, Koh H, Twombly TS, Mima K, Morikawa T, Song M, Nowak JA, Nishihara R, Saltz LB, Niedzwiecki D, Ou FS, Zemla T, Mayer RJ, Baba H, Ng K, Giannakis M, Zhang X, Wu K, Giovannucci EL, Chan AT, Fuchs CS, Meyerhardt JA, Ogino S. Prognostic association of PTGS2 (COX-2) over-expression according to BRAF mutation status in colorectal cancer: Results from two prospective cohorts and CALGB 89803 (Alliance) trial. Eur J Cancer. 2019 Apr;111:82-93. (co-first author)

16. Yang W, Liu L, Masugi Y, Qian ZR, Nishihara R, Keum N, Wu K, Smith-Warner S, Ma Y, Nowak JA, Momen-Heravi F, Zhang L, Bowden M, Morikawa T, Silva AD, Wang M, Chan AT, Fuchs CS, Meyerhardt JA, Ng K, Giovannucci E, Ogino S, Zhang X. Calcium intake and risk of colorectal cancer according to expression status of calcium-sensing receptor (CASR). Gut. 2018 Aug;67(8):1475-1483. (co-first author)

17. Liu L, Tabung FK, Zhang X, Nowak JA, Qian ZR, Hamada T, Nevo D, Bullman S, Mima K, Kosumi K, da Silva A, Song M, Cao Y, Twombly TS, Shi Y, Liu H, Gu M, Koh H, Li W, Du C, Chen Y, Li C, Li W, Mehta RS, Wu K, Wang M, Kostic AD, Giannakis M, Garrett WS, Hutthenhower C, Chan AT, Fuchs CS, Nishihara R, Ogino S, Giovannucci EL. Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum. Clin Gastroenterol Hepatol. 2018 Oct;16(10):1622-1631.e3.

18. Hamada T, Liu L, Nowak JA, Mima K, Cao Y, Ng K, Twombly TS, Song M, Jung S, Dou R, Masugi Y, Kosumi K, Shi Y, da Silva A, Gu M, Li W, Keum N, Wu K, Nosho K, Inamura K, Meyerhardt JA, Nevo D, Wang M, Giannakis M, Chan AT, Giovannucci EL, Fuchs CS, Nishihara R, Zhang Z, Ogino S. Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour. Eur J Cancer. 2018 Sep 12;103:98-107. (co-first author)

19. Liu L, Nevo D, Nishihara R, Cao Y, Song M, Twombly TS, Chan AT, Giovannucci EL, VanderWeele TJ, Wang M, Ogino S. Utility of inverse probability weighting in molecular pathological epidemiology. Eur J Epidemiol. 2018 Apr;33(4):381-392.

20. Liu L, Nishihara R, Qian ZR, Tabung FK, Nevo D, Zhang X, Song M, Cao Y, Mima K, Masugi Y, Shi Y, da Silva A, Twombly T, Gu M, Li W, Hamada T, Kosumi K, Inamura K, Nowak JA, Drew DA, Lochhead P, Nosho K, Wu K, Wang M, Garrett WS, Chan AT, Fuchs CS, Giovannucci EL, Ogino S. Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor. Gastroenterology. 2017 Dec;153(6):1517-1530.e14.

21. Li T, Wei S, Shi Y, Pang S, Qin Q, Yin J, Deng Y, Chen Q, Wei S, Nie S, Liu L. The dose-response effect of physical activity on cancer mortality: findings from 71 prospective cohort studies. Br J Sports Med. 2016 Mar;50(6):339-345.

22. Liu L, Shi Y, Li T, Qin Q, Yin J, Pang S, Nie S, Wei S. Leisure time physical activity and cancer risk: evaluation of the WHO's recommendation based on 126 high-quality epidemiological studies. Br J Sports Med. 2016 Mar;50(6):372-378.

主要社会兼职

中国健康促进与教育协会肿瘤筛查和预防专业委员会常务委员

湖北省医学会临床流行病学与循证医学专业委员会副主任委员

湖北省微循环学会结直肠肛门肿瘤防控专业委员会副主任委员

中国临床肿瘤学会生物统计学专家委员会委员

中国抗癌协会癌症筛查与早诊早治专业委员会委员

中国抗癌协会肿瘤病因专业委员会委员

中国抗癌协会肿瘤流行病专业委员会委员

湖北省预防医学会流行病学分会第七届委员会常务委员

武汉市预防医学会第一届医院公共卫生专业委员会主任委员