Education

1983  B.Sc., Hunan Medical University, P.R. China

1988  M.Sc., Tongji Medical University, P.R. China

1990 Ph.D.,Tongji Medical University, P.R. China

Working experience

1993–1995 Lecturer,TongjiMedicalUniversity, P.R. China

1996-1999 Assistant Professor,TongjiMedicalUniversity, P.R. China

1999.6-1999.12 Visiting Scholar, Max Planck Institute of Biochemistry,Germany

2002.10-2002.12 Visiting Scholar,University of Tuebingen,Germany

2005.11-2006.1 Visiting Scholar,University of Tuebingen,Germany

Since 2000 Professor, School of Public Health,TongjiMedicalCollegeHuazhongUniversityof Science and Technology, P.R. China

Since 2006 Vice Dean, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, P.R. China

Major research interests

1.  Environmental pollutants on fetal origins of adult diseases

2.  Toxicity of endocrine disruptors (EDCs) on developmental origins of adult disease.

3.  Develop bioassay methods to detect EDCs or biomarkers in environment and assess their combined effects

Funding Information

1.  Fetal exposure of endocrine disruptors increases the susceptibility and risk of metabolic disorders in adulthood, Key Project of National Natural Science Foundation of China 21437002 (PI, 01/01/15 – 12/31/19)

2.  Method development for ambient air quality standard for lead based on health risk assessment, R&D Special Fund for Public Welfare Industry 201309048 (PI, 01/01/13-12/31/15)

3.   Impact of endocrine disruptors on glucose metabolism, National Key Basic Research Program of China  2012CB722401 (PI, 01/01/12-12/31/14)

4.  Screening of estrogen-like compounds in food and risk assessment of metabolic syndrome, Key Project of National Natural Science Foundation of China  81030051   (PI, 01/01/12-12/31/14)

5.  Technical guidance for survey of environment and health in national key regions, Scientific Grant, Ministry of Environmental Protection 2111101110124   (01/01/10-12/31/14 )

Teaching course

1.   Analysis Technique of Molecular Biology, compulsory course

2.   Household Chemicals and Health, optional course

Publications (*corresponding author)

1.  Wei Xia, Xiaofu Du, Bin Zhang, Yuanyuan Li, Bryan A. Bassig, Aifen Zhou, Youjie Wang, Chao Xiong, Zhengkuan Li, Yuanxiang Yao, Jie Hu, Yanqiu Zhou, Qi Wang, Juan Liu, Weiyan Xue, Yue Ma, Xinyun Pan, Yang Peng, Tongzhang Zheng, and Shunqing Xu*. A Case–Control Study of Prenatal Thallium Exposure and Low Birth Weight in China. Environ Health Perspect. DOI:10.1289/ehp.1409202.

2. Ying Jiang , Wei Xia, Jie Yang, Yingshuang Zhu, Huailong Chang, Juan Liu, Wenqian Huo, Bing Xu , Xi Chen, Yuanyuan Li, Shunqing Xu*. BPA-induced DNA hypermethylation of the master mitochondrial gene PGC-1alpha contributes to cardiomyopathy in male rats. Toxicology. 2015 Mar 2;329:21-31.

3. Jun Wang, Wei Xia, Yonghua Xiao, Chenjiang Ying, Jia Long, Hui Zhang, Xi Chen, Congda Mao, Xiumin Li, Li Wang, Shunqing X*. Assessment of estrogen disrupting potency in animal foodstuffs of China by combined biological and chemical analyses. J Environ Sci (China). 2014 Oct 1;26(10):2131-7.

4. Jie Wei, Xia Sun, Yajie Chen, Yuanyuan Li, Liqiong Song, Zhao  Zhou, Bing Xu, Yi Lin, Shunqing Xu *. Perinatal exposure to bisphenol A exacerbates nonalcoholic steatohepatitis-like phenotype in male rat offspring fed on a high-fat diet. J Endocrinol. 2014 Sep;222(3):313-25.

5. Ying Jiang, Juan Liu, Yuanyuan Li, Huailong Chang, Genqi Li, Bing Xu, Xi Chen, Weiyong Li, Wei Xia, Shunqing Xu*. Prenatal exposure to bisphenol A at the reference dose impairs mitochondria in the heart of neonatal rats. J Appl Toxicol. 2014 Sep;34(9):1012-22.

6.  Genqi Li, Huailong Chang, Wei Xia, Zhenxing Mao, Yuanyuan Li, Shunqing Xu*. F0 maternal BPA exposure induced glucose intolerance of F2 generation through DNA methylation change in Gck. Toxicol Lett. 2014 Aug 4;228(3):192-9.

7.  Ying Jiang , Wei Xia, Yingshuang Zhu, Xiaocui  Li, Danqi Wang, Juan Liu, Huailong Chang, Genqi Li, Bing Xu, Xi Chen, Yuanyuan Li, Shunqing Xu*. Mitochondrial dysfunction in early life resulted from perinatal bisphenol A exposure contributes to hepatic steatosis in rat offspring. Toxicol Lett. 2014 Jul 15;228(2):85-92.

8.  Hongyu Zhang, Weiyan Xue,Yuanyuan Li, Yue Ma, Yingshuang Zhu, Wenqian Huo, Bing Xu, Wei Xia, Shunqing Xu*.Perinatal exposure to 4-nonylphenol affects adipogenesis in first and second generation rats offspring. Toxicol Lett. 2014 Mar 3;225(2):325-32.

9.  Wei Xia, Ying Jiang, Yuanyuan Li, Yanjian Wan, Juan Liu, Yue Ma, Zhenxing Mao, Huailong Chang, Genqi Li, Bing Xu, Xi Chen, Shunqing Xu*. Early-Life Exposure to Bisphenol A Induces Liver Injury in Rats Involvement of Mitochondria-Mediated Apoptosis. PLoS One. 2014 Feb 28;9(2):e90443.

10.  Zhenxing Mao, Wei Xia, Jun Wang, Tian Chen, Qianqian Zeng, Bing Xu, Weiyong Li, Xi Chen, Shunqing Xu*. Perfluorooctane sulfonate induces apoptosis in lung cancer A549 cells through reactive oxygen species-mediated mitochondrion-dependent pathway. J Appl Toxicol. 2013 Nov;33(11):1268-76.

11.  Yue Ma, Wei Xia, Danqi Wang, Yanjian Wan, Bing Xu, Xi Chen, Yuanyuan Li, Shunqing Xu*. Hepatic DNA methylation modifications in early development of rats resulting from perinatal BPA exposure contribute to insulin resistance in adulthood. Diabetologia. 2013, 56(9):2059-67.

12.  Ziquan Lv, Gengqi Li, Yuanyuan Li, Chenjiang Ying, Jun Chen, Tian Chen, Jie Wei, Yi Lin, Ying Jiang, Youjie Wang, Baihuai Shu, Bing Xu, Shunqing Xu*. Glucose and lipid homeostasis in adult rat is impaired by early-life exposure to perfluorooctane sulfonate. Environ Toxicol, 2013, 28(9):532-42.

13.  Liqiong Song, Wei Xia, Zhao Zhou, Yi Li, Jie Wei, Zhengzheng Wei, Bing Xu, Jie Shen, Weiyong Li, Shunqing Xu*. Low-level phenolic estrogen pollutants impair islet morphology and β-cell function in isolated rat islets. J Endocrinol, 2012, 215(2):303-11.

14.  Tian Chen, Ling Zhang, JunquanYue, Ziquan Lv, Wei Xia, Yanjian Wan, Yuanyuan Li, Shunqing Xu*. Prenatal PFOS exposure induces oxidative stress and apoptosis in the lung of rat off-spring. Reprod Toxicol, 2012, 33(4):538-45.

15.  Zhengzheng Wei, Liqiong Song, Jie Wei, Tian Chen, Jun Chen, Yi Lin, Wei Xia, Bing Xu, Xuguang Li, Xi Chen, Yuanyuan Li, Shunqing Xu*. Maternal exposure to di-(2-ethylhexyl)phthalate alters kidney development through the renin-angiotensin system in offspring. Toxicol Lett, 2012, 212(2):212-21.

16.  Jun Chen, Zhifei Chen, Yuanyuan Li, Wei Xia, Xi Chen, Tian Chen, Liping Zhou, Bing Xu, Shunqing Xu*. Characterization of gyrA and gyrB mutations and fluoroquinolone resistance in Mycobacterium tuberculosis clinical isolates from Hubei Province, China. Braz J Infect Dis, 2012, 16(2):136-141.

17.  Yuanyuan Li, Tian Chen, Yanjian Wan, Shunqing Xu*. Lead exposure in pheochromocytoma cells induces persistent changes in amyloid precursor protein gene methylation patterns. Environ Toxicol, 2012, 27(8):495-502.

18.  Wei Xia, Yanjian Wan, Xianliang Wang, Yuanyuan Li, Wenjie Yang, Chunxiang Wang, Shunqing Xu*. Sensitive bioassay for detection of PPARα potentially hazardous ligands with gold nanoparticle probe. J Hazard Mater, 2011, 192(3):1148-54.

19.  Yi Lin, Jie Wei, Yuanyuan Li, Jun Chen, Zhao Zhou, Liqiong Song, Zhengzheng Wei, Ziquan Lv, Xi Chen, Wei Xia, Shunqing Xu*. Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat. Am J Physiol Endocrinol Metab, 2011, 301(3):E527-38.

20.  Jie Wei, Yi Lin, Yuanyuan Li, Chenjiang Ying, Jun Chen, Liqiong Song, Zhao Zhou, Ziquan Lv, Wei Xia, Xi Chen, Shunqing Xu*. Perinatal exposure to bisphenol A at reference dose predisposes offspring to metabolic syndrome in adult rats on a high-fat diet. Endocrinology, 2011, 152(8):3049-61.

21.  Yuqiu Gao, Tian Chen, Yanjian Wan, Yuanyuan Li, Shunqing Xu*. Densitometry determination of estrogenic EDCs with gold nanoparticlemodified oestrogen response element assay. Inter J Environ Anal Chem, 2011, 91(5): 401-409.

22.  Ling Zhang, Yuanyuan Li, Tian Chen, Wei Xia, Ying Zhou, Yanjian Wan, Ziquan Lv, Gengqi Li, Shunqing Xu*. Abnormal development of motor neurons in perfluorooctane sulphonate exposed zebrafish embryos. Ecotoxicology, 2011, 20(4):643-52.

23.  Wei Xia, Yanjian Wan, Yuanyuan Li, Huaicai Zeng, Ziquan Lv, Gengqi Li, Zhengzheng Wei, Shunqing Xu*. PFOS prenatal exposure induce mitochondrial injury and gene expression change in hearts of weaned SD rats. Toxicology, 2011, 282(1-2):23-9.

24.  Tian Chen, Wenjie Yang, Yuanyuan Li, Xi Chen, Shunqing Xu*. Mono-(2-ethylhexyl) phthalate impairs neurodevelopment: inhibition of proliferation and promotion of differentiation in PC12 cells. Toxicol Lett, 2011, 201(1):34-41.

25.  Ling Zhang, Yuanyuan Li, Huaicai Zeng, Miao Li, Yanjian Wan, Hermann J Schluesener, Zhiren Zhang, Shunqing Xu*. Perfluorooctane Sulfonate Induces Apoptosis in N9 Microglial Cell Line. Int J Toxicol, 2010, 30(2):207-2011.

26.  Huaicai Zeng, Ling Zhang, Yuanyuan Li, Yanjian Wan, Wei Xia, Yi Lin, Jie Wei, Shunqing Xu*. Inflammation-like glial response in rat brain induced by prenatal PFOS exposure. Neurotoxicology, 2011, 32(1):130-9.

27.  Tian Chen, Yuanyuan Li, J Zhang, Bing Xu, Yi Lin, Chunxiang Wang, Yanjian Wan, Shunqing Xu*. Protective effect of C(60)-methionine derivate on lead-exposed human SH-SY5Y neuroblastoma cells. J Appl Toxicol, 2011, 31(3):255-61.

28.  Ling Zhang, Yuanyuan Li, Huaicai Zeng, Jie Wei, Yanjian Wan, Jun Chen, Shunqing Xu*. MicroRNA expression changes during zebrafish development induced by perfluorooctane sulfonate. J Appl Toxicol, 2011, 31(3):210-22.

29.  Huaicai Zeng, Yuanyuan Li, Ling Zhang, Yanjian Wan, J Chen, Wei Xia, Yi Lin, Jie Wei, Ziquan Lv, Miao Li, Shunqing Xu*. Prenatal exposure to perfluorooctanesulfonate in rat resulted in long-lasting changes of expression of synapsins and synaptophysin. Synapse, 2011, 65(3):225-33.

30.  Yuanyuang Li, Hermann J Schluesene, Shunqing Xu*, Gold nanoparticle-based biosensors. Gold bulletin, 2010, 43(1): 29-41.

31.  Yan-jian Wan, Yuan-yuan Li, Wei Xia, Jun Chen, Zi-quan Lv, Huai-cai Zeng, Ling Zhang, Wen-jie Yang, Tian Chen, Yi Lin, Jie Wei, Shun-qing Xu*. Alterations in tumor biomarker rGSTP gene methylation patterns induced by prenatal exposure to PFOS. Toxicology, 2010, 274: 57-64.

32. Wei Xia, Yuanyuan Li, Yanjian Wan, Tian Chen, Jie Wei, Yi Lin, Shunqing Xu*. Electrochemical biosensor for estrogenic substance using lipid bilayers modified by Au nanoparticles. Biosens and Bioelectron, 2010, 25(10):2253-8.

33.  Chuangxiang Wang, Shunqing Xu*, Ziquan Lv, Yuanyuan Li, Youjie Wang, Tian Chen. Exposure to persistent organic pollutants as potential risk factors for developing diabetes. Science China-Chemistry, 2010, 53(5):980-994.

34.  Xiao-bo Li, Hao Zheng, Zhi-ren Zhang, Miao Li, Zhi-yong Huang, Hermann J. Schluesener, Yuan-yuan Li, Shun-qing Xu*. Glia activation induced by peripheral administration of aluminium oxide nanoparticles in rat brains. Nanomed-Nanotech, 2009, 5(4): 473-9.

35.  Xiao-Bo Li, Shun-Qing Xu, Zhi-Ren Zhang, Hermann J Schluesener. Apoptosis induced by titanium dioxide nanoparticles in cultured murine microglia N9 cells. Chinese Science Bulletin, 2009, 54(20): 3830-3836.

36. Yuanyuan Li, Zhifei Chen, Hongling Zhang, Xiaobo Li,  Jie Shen, Shi Lu, Shunqing Xu*. Inhibition of inositol-1-phosphate synthetase in Mycobacterium tuberculosis by chitosan-antisense nanoparticles. J Wuhan University of Technology-Materials Science Edition, 2009, 24(1):87-90.

37.  Wen-Jie Yang, Xiao-Bo Li, Yuan-Yuan Li, Li-Fan Zhao, Wen-Lei He, Yu-Qiu Gao, Yan-Jian Wan, Wei Xia, Tian Chen, Hao Zheng, Miao Li, Shun-Qing Xu*. Quantification of microRNA by gold nanoparticle probes. Anal Biochem, 2008, 15; 376(2):183-8.

38.  Chi Zhang, Yuan-Yuan Li, Xian-Liang Wang, Li-Jun Zhang, Xiao-Bo Li, You-Jie Wang, Shun-Qing Xu*. High-throughput identification of mutations using a combination of CEL I fragmentation and SAGE technology. Genetic Test Mol Biomarkers, 2009, 13(1): 97–103.

39.  Robbie Ali, Kenneth Olden, Shunqing Xu, Community-based participatory rsearch: a vehicle to promote public engagement for environmental health in China. Environ Health Perspect, 2008, 116(10): 1281-4.

40.  Li-Fan Zhao, Li Li, Yu-Qiu Gao, Bo-Sheng Li, Yuan-Yuan Li, Chang-Hua Shi, Tian Chen, Wen-Jie Yang, Xiao-Bo Li, Shun-Qing Xu*.  Densitometry Determination of Dioxins Using Gold Nanoparticle-Modified Dioxin Response Element Probes. Gold Bulletin, 2007, 40(4): 305-309.

41.  Yuan-Yuan Li, Chi Zhang, Bo-Sheng Li, Li-Fan Zhao, Xiao-bo Li, Jie Shen, Shun-Qing Xu*. Ultrasensitive densitometry detection of cytokines with nanoparticle-modified aptamers. Clin Chem, 2007; 53(6):1061-6.

42.  Yuan-Yuan Li, Zhi-Fei Chen, Xiao-Bo Li, Hong-Ling Zhang, Qiang Huang, Ying Zhang, Shun-Qing Xu*.  Inositol-1-phosphate synthetase mRNA as a new target for antisense inhibition of Mycobacterium tuberculosis. J Biotechnol, 2007 128(4): 726-34.

43.  Qiang Huang, Zhi-fen Chen, Yuan-yuan Li, Ying Zhang, Yi Ren, Zhi-jun Fu, Shun-qing Xu*. Nutrient-starved incubation conditions enhance pyrazinamide activity against Mycobacterium tuberculosis. Chemotherapy, 2007; 53(5):338-43.

44.  Yi Xiang, Qingsong Yu, Zhi Qi, Zhenade Du, Shunqing Xu, Huafeng Zhang. Enhancement of immunological activity of CpG ODN by chitosan gene carrier. J Huazhong U Sci -Med, 2007, 27(2): 128-130.

45.  Xiao-Bo Li, Zhi-Ren Zhang, Hermann J. Schluesener, Shun-Qing Xu*. Role of exosomes in immune regulation. J Cell Mol Med, 2006, 10(2): 264-375.

46.  Xianliang Wang, Chi Zhang, Lijun Zhang, Xiaoli Wang, Shunqing Xu*. High throughput assay of DNA methylation based on methylation-specific primer and SAGE. Biochem Biophys Res Commun, 2006, 341:749-754.

47. Bo-sheng Li, Li-fan Zhao, Chi Zhang, Xiao-han Hei, Fang Li, Xiao-bo Li, Jie Shen, Yuan-yuan Li, Qiang Huang, Shun-qing Xu*. Ultra-sensitive colorimetric method to quantitate hundreds of polynucleotide molecules by gold nanoparticles with silver enhancement. Anal Sci, 2006, 22: 1367-1370.

48.  Xianliang Wang, Yongjian Yang, Xiaoli Wang, Shunqing Xu*. The effect of occupational exposure to metals in welders on nervous system. J Occup Health, 2006, 48(2): 100-6.

49.  Xiao-Bo Li, Hermann J. Schluesener, Shun-Qing Xu. Molecular addresses of tumors: selection by in vivo phage display. Arch Immunol Ther Exp, 2006, 54:1-5.

50. Yanhua Su, Zhiren Zhang, Katrin Trautmann, Shunqing Xu, Hermann J.Schluesener. TLR and NOD2 ligands induce cell proliferation in the rat intact spinal cord. J Neuropath Exp Neur, 2005, 64(11):991-997.

51.  Xiao-Li Wang, Fang Li, Yan-Hua Su, Xi Sun, Xiao-Bo Li, Hermann J. Schluesener, Fei Tang, Shun-Qing Xu*. Ultrasensitive detection of protein using an aptamer-based exonuclease protection assay. Anal Chem, 2004, 76(19):5605-10.

52.  Xi Sun, Fang Li, You-Jie Wang, Yi-Rong Li, Yan-hua Su, Yuan-yuan Li, Hong Yan, Shun-Qing Xu*. Development an exonuclease protection mediated PCR bioassay for sensitive detection of Ah receptor agonists. Toxicol Sci, 2004, 80(1):49-53.

53.  Hong-Ping Yu, Yuan-Yuan Li, Fang Li, Xiao-Li Wang, Yan-Hua Su, Xi Sun, Bin Lu, You-Jie Wang, Shun-Qing Xu*. Telomerase activity and expression of telomerase genes in squamous dysplasia and squamous cell carcinoma of the esophagus. J Surg Oncol, 2004, 86(2):99-104.

54.  Hong-Ping Yu, Xiao-Li Wang, Yan-Hua Su, You-Jie Wang, Bin Lu, Lu-Yuan Shi, Chun-lan Xiong, Yuan-Yuan Li, Fang Li, Shun-Qing Xu*. Polymorphisms in the DNA repair gene XPD and susceptibility to esophageal squamous cell carcinoma. Cancer Genet Cytogene, 2004, 154(1):10-5.

55.  Hong-Ping Yu, Xiao-Yong Zhang, Xiao-Li Wang, Lu-Yuan Shi, Yuan-Yuan Li, Fang Li, Yan-Hua Su, You-Jie Wang, Bin Lu, Xi Sun,Wen-Hong Lu，Shun-Qing Xu*. DNA repair gene XRCC1 polymorphisms, smoking, and esophageal cancer risk. Cancer Detect Prev, 2004, 28(3):194-9.

56.  Hong-Ping Yu, Lu-Yuan Shi, Wen-Hong Lu, Yan-Hua Su, Yuan-Yuan Li, Shun-Qing Xu*. Expression of cyclooxygenase-2(cox-2) in human esophageal cancer and in vitro inhibition by a specific cox-2 inhibitor, NS-398. J Gastroen Hepatol, 2004, 19(6):638-642.

57.  Xiaoming Wu, Yikai Zhou, Shun-Qing Xu. Chemiluminescent detection of genetic polymorphisms based on mismatch hybridization: application to cytochrome P4501A1. Mol Cell Probes, 2004; 18: 17–22.

58.  Hong-Ping Yu, Shun-Qing Xu*, Li Liu, Lu-Yuan Shi, Xiao-Kun Cai, Wen-Hong Lu, Bin Lu, Yan-Hua Su, Yuan-Yuan Li. Cyclooxygenase-2 expression in squamous dysplasia and squamous cell carcinoma of the esophagus. Cancer Lett, 2003; 198(2):193-201.

59.  Zhiren Zhang, Shun-Qing Xu*, Sun X, Xu YJ, Cai XK, Liu ZW, Tan XL, Zhou YK, Zhang JY, Yan H. Characteristics and application of established luciferase hepatoma cell line that responds to dioxin-like chemicals. World J Gastroenterol, 2003, 9(7):1460-4.

60.  Xiaoming Wu, Wei Fan, Shun-Qing Xu, Yikai Zhou. Sensitization to the cytotoxicity of Cisplatin by transfection with nucleotide excision repair gene xeroderma pigmentosun group a antisense RNA in human lung adenocarcinoma cells. Clin Cancer Res, 2003, 9(16):5874-9.

61.  Shun-Qing Xu*, Min He, Hong-Ping Yu, Xiao-Yang Wang, Xiang-Lin Tan, Bin Lu, Xi Sun, Yi-Kai Zhou, Qun-Feng Yao, Yong-Jun Xu, and Zhi-Ren Zhang. Bioluminescent method for detecting telomerase activity. Clin Chem, 2002, 48(7):1016-1020.

62.  Xiaoming Wu, Yikai Zhou, Shun-Qing Xu. Detection of CYP I A1 polymorphisms with a colorimetric method based on mismatch hybridization. Clin Chim Acta, 2002, 323: 103-109.

63.  Dachun Yao, Athanasios G. Vlessidis, Nicholaos P. Evmiridis,Yikai Zhou, Shun-Qing Xu, Huarong Zhou. Novel chemiluminescence method for detection of superoxide anions and its application to dry-cured meat. Anal Chim Acta, 2002, 476:145–153.

64.  Zhi-Ren Zhang, Shun-Qing Xu*, Yi-Kai Zhou, Yong-Jun Xu, Zhi-Wei Liu, Xiao-Kun Cai, Xiang-Lin Tan. Improvement of chemically-activated luciferase gene expression bioassay for detection of dioxin-like chemicals. Biomed Environ Sciences, 2002, 15(1):58-66.

65.  Shun-Qing Xu*, Min He, HongpingYu, Xiaokun Cai, Xianglin Tan, Bin Lu, Baihua Shu. Quantitative method to measure telomerase activity by bioluminescence connected with telomeric repeat amplification protocol. Anal Biochem, 2001, 299(2):188-93.