职务：副研究员、博士生导师
地址：华中科技大学同济医学院公共卫生学院1号楼609室
邮箱：xiasheng@hust.edu.cn
研究简介
盛夏，挪威奥斯陆大学分子生物学博士、博士后；2018年作为引进人才加入华中科技大学公共卫生学院环境医学研究所。从事内质网应激在疾病起源和发展中的作用机制研究，发表SCI论文50余篇，以第一或通讯作者（含共同）在Advanced Science，Nature Communications，EMBO Molecular Medicine等主流期刊发表论文15篇，累计引用超千次。
研究方向
1. 神经毒理：从内质网应激的角度阐明环境因素损伤认知发育的毒理机制
2. 肿瘤防治：从内质网稳态的角度探索肿瘤预警新策略与靶向干预新机制
学术兼职
1. 中国环境诱变剂学会致突变专业委员会青年委员
2. Frontiers in Endocrinology特邀编辑
3. Advanced Science、EMBO Mol Med等期刊审稿人
科研项目
1. 中央军委后勤保障部研究项目，骨干
2. 湖北省自然科学基金面上项目，主持
3. 国家自然科学基金青年基金，主持
4. 华中科技大学自主创新基金，主持
奖励荣誉
2022 华中科技大学青年五四奖章
2021 湖北省“百人计划”
2015、2019 奥斯陆大学年度最佳生命科学类论文（2次）
2010 中国-欧盟“世界之窗”奖学金
代表论文（#共同第一作者，*通讯作者）
1. Xiao R#, You L#, Zhang L, Guo X, Guo E, Zhao F, Yang B, Li X, Fu Y, Lu F, Wang Z, Liu C, Peng W, Li W, Yang X, Dou Y, Liu J, Wang W, Qin T, Cui Y, Zhang X, Li F, Jin Y, Zeng Q, Wang B, Mills GB, Chen G*, Sheng X*, Sun C*. Inhibiting the IRE1α axis of the unfolded protein response enhances the anti-tumor effect of AZD1775 in TP53 mutant ovarian cancer. Advanced Science. 2022: e2105469.
2. Shi C#, Zhao F#, Zhang T#, Xu D, Hao Z, Cui F, Shi JH, Jin Y, Li N, Yang C, Zhang Y*, Sheng X*. A novel prognostic signature in osteosarcoma characterized from the perspective of unfolded protein response. Clinical and Translational Medicine, 2022; 12: e750.
3. Wang G#, Zhang M#, Meng P#, Long C#, Luo X#, Yang X, Wang Y, Zhang Z, Mwangi J, Kamau PM, Dai Z, Ke Z, Zhang Y, Chen W, Zhao X, Ge F, Lv Q, Rong M, Li D, Jin Y*, Sheng X*, Lai R*. Anticarin-β shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis. Acta Pharmaceutica Sinica B. 2022; 12(5): 2268-2279.
4. Cui F#, Pan Q#, Wang S, Zhao F, Wang R, Zhang T, Song Y, He J, Zhang H, Weng Q, Jin Y, Xia W, Li Y, Yang GY, De Vos W, Timmermans JP, Xu S*, Tang Y*, Sheng X*. Maternal benzophenone exposure impairs hippocampus development and cognitive function in mouse offspring. Advanced Science. 2021; 8(23): e2102686. (卷首故事)
5. Zhang P#*, Li S#, Zhang T, Cui F, Shi JH, Zhao F*, Sheng X*. Characterization of molecular subtypes in head and neck squamous cell carcinoma with distinct prognosis and treatment responsiveness. Frontiers in Cell and Developmental Biology. 2021; 9: 711348.
6. Zhang T, Li N, Sun C, Jin Y, Sheng X*. MYC and the unfolded protein response in cancer: synthetic lethal partners in crime? EMBO Molecular Medicine. 2020; 12(5): e11845.
7. Zhang W, Liu W, Bao S, Liu H, Zhang Y, Zhang B, Zhou A, Chen J, Hao K, Xia W, Li Y, Sheng X*, Xu S*. Association of adverse birth outcomes with prenatal uranium exposure: A population-based cohort study. Environment International. 2020; 135: 105391. (IF=9.6)
8. Sheng X, Nenseth HZ, Qu S, Kuzu OF, Frahnow T, Simon L, Greene S, Zeng Q, Fazli L, Rennie PS, Mills IG, Danielsen H, Theis F, Patterson JB, Jin Y, Saatcioglu F. IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling. Nature Communications. 2019; 10(1): 323. (Nature Reviews Urology研究亮点，ESI高被引)
9. Wang Y, Wang K, Jin Y, Sheng X*. Endoplasmic reticulum proteostasis control and gastric cancer. Cancer Letters. 2019; 449: 263-271.
10. Sheng X#, Arnoldussen YJ# Storm ML#, Tesikova M, Jin Y, Nenseth HZ, Zhao S, Mills IG, Fazli L, Rennie P, Risberg B, Wæhre H, Danielsen HE, Hotamisligil GS, Saatcioglu F. Divergent androgen regulation of unfolded protein response pathways drives prostate cancer. EMBO Molecular Medicine. 2015; 7(6): 788-801.
学术会议
1. 大会负责人，2021年内质网蛋白稳态与疾病国际学术会议。2021年10月，湖北武汉。
