职务：教授

院系：公共卫生学院

地址：湖北省武汉市航空路13号 430030

电话：86-27-83610968

邮箱：xtshenlab@hust.edu.cn

个人简介

2002年6月在华中科技大学精细化工专业获得学士学位。2007年1月在华中科技大学分析化学专业获得硕士学位，毕业论文获得湖北省2008年优秀硕士论文（No. 1）。2010年3月在华中科技大学材料物理与化学专业获得博士学位。2010年-2012年在瑞典隆德大学从事博士后研究工作，2013-2014年在挪威G&T Septech公司（奥斯陆大学）从事研究工作。2014-2015年在瑞典马尔默大学担任客座研究员。2015年加入华中科技大学公共卫生学院担任教授。

主要从事多功能分子识别材料在环境有机污染物、生物蛋白质与肽、生物细胞及微生物的分离及监测等方面的研究工作。近年来先后主持和参与中国、瑞典、挪威、欧盟等多项科研项目，至今发表论文60余篇，合计引用次数超过2000次。获得湖北省自然科学二等奖1项

研究方向

1. 多功能分离识别材料的制备：分子印迹技术是制备对特定目标分子具有特异性识别性能人工抗体的技术。课题组将合成的分子印迹聚合物选择性富集复杂人群样品中的目标污染物，用于人群污染物内暴露评估。

2. 新型样品前处理技术：电膜萃取技术是在液相微萃取的基础上发展起来的电场辅助液相微萃取技术，其使用更少的有机溶剂，实验简单快速。课题组将该技术由于人群样品中的目标物的分离与检测，如对人血浆样本中各种氨基酸的萃取。

3. 环境污染物暴露的健康效应：研究重金属与环境内分泌干扰物等环境污染物暴露对母婴健康的影响，如对母婴内分泌系统的干扰作用及婴幼儿生长发育的影响。

主要承担的科研项目

1. 科技部重点研发子课题：重点行业场地健康风险与生物标志物的关联模型，2020/01-2023/12, 资助经费：424万元，在研，主持

2. 国家自然科学基金面上项目，基于细菌趋化性的第二代细菌印迹技术研究，2019/01-2022/12, 资助经费：64万元，在研，主持

3. 国家自然科学基金面上项目:基于分子印迹型MOFs催化剂去除典型抗生素类污染物的研究，2017/01-2020/12, 资助经费：66万元，已结题，主持

4. 华中科技大学自主创新研究基金：基于分子识别的聚集诱导发光技术在糖尿病代谢标志物检测中的应用研究,  2016/04-2018/12,资助经费： 10万元，已结题，主持

5. 华中科技大学自主创新重点专项项目：多重纳米仿酶催化体系氧化环化生长激素抑制素类环肽的研究,  2015/05-2016/12,资助经费：8万元，已结题，主持

6. 湖北省青年科技晨光计划：分子印迹与电膜萃取联用技术在萃取血浆中的多肽的研究, 2015-2016,资助经费：1万元，已结题，主持

代表性论著和专利

一、英文文章  

(1) Li J.; Zhu R.; Shen X.; Huang C.* Functional materials and chemicals in electromembrane extraction. Trends in Analytical Chemistry, 2022, doi.org/10.1016/j.trac.2022.116574.

(2) Yan Y.; Jiang L.; Zhang S.; Shen X.*; Huang C.* Specific "light-up" sensor made easy: An aggregation induced emission monomer for molecular imprinting. Biosensors and Bioelectronics, 2022, 205:114113. (IF=10.618)

(3) Hong C.; Dong Y.; Zhu R.; Yan Y.; Shen X.; Pedersen-Bjergaard, S.; Huang C.* Effect of sample matrices on supported liquid membrane: Efficient electromembrane extraction of cathinones from biological samples. Talanta, 2022, 240:123175. (IF=6.057)

(4) Zhu R.; Mei H.; Liu H.; Hong C.; Shen X.; Huang C.* Successive liquid-phase microextraction of acidic and basic analytes. Analytica Chimica Acta, 2022, 1192: 339335. (IF=6.558)

(5) Lin, B.; Liu, H.; Huang, C.*; Xiao, X.; Pedersen-Bjergaard, S.; Shen, X.* Versatile integration of liquid-phase microextraction and fluorescent aptamer beacons: A synergistic effect for bioanalysis. Analytical Chemistry, 2021, 93(42),14323-14333. (IF=6.986)

(6) Shang, Q.; Mei, H.; Feng, X.; Huang, C.*; Pedersen-Bjergaard, S.; Shen, X.* Ultrasound-assisted electromembrane extraction with supported semi-liquid membrane. Analytica Chimica Acta, 2021, 1184: 339038. (IF: 6.558, Times Cited: 1)

(7) Chen, L.; Wang, J.; Xu, T.; Feng, X.; Huang, C.; Shen, X.* Recent sample pretreatment methods for determination of selective serotonin reuptake inhibitors (SSRIs) in biological samples. Journal of Pharmaceutical and Biomedical Analysis, 2021, 206:114364. (IF=3.935, Times Cited: 1)

(8) Yu, Y.; Qi, Z.; Ma, S.; Xu, L.; Zheng, J.; Gao, Y.; Shen, X.; Cai, Y.; Zhang, W.; Li, G.; An, T.* Human exposome and biomarker database for soil pollutants at typical sites of industrial contamination. Science Bulletin, 2021, 66(17). (IF=11.78, Times Cited: 1)

(9) Liu, C.; Huang, D.; Yang, L.; Wu, S.; Shen, X.*; Pedersen-Bjergaard, S.; Huang, C.* Removal of polymerase chain reaction inhibitors by electromembrane extraction. Analytical Chemistry, 2021, 93(33),11488-11496. (IF=6.986, Times Cited: 2)

(10) Chen, Z.; Luo, Y.; Huang, C.*; Shen, X.* In situ assembly of ZnO/graphene oxide on synthetic molecular receptors: Towards selective photoreduction of Cr(VI) via interfacial synergistic catalysis. Chemical Engineering Journal, 2021, 414, 128914. (IF=10.652, Times Cited: 9)

(11) Mei, H.; Liu, H.; Shang, Q.; Huang, C.*; Shen, X.* Organic-solvent-free electromembrane extraction based on semi-interpenetrating polymer networks. Green Chemistry, 2021, 23, 1782-1793. (IF=10.182, Times cited: 3)

(12) Wan, L.; Liu, H.; Huang, C.*; Shen, X.* Enzyme-like MOFs: Synthetic molecular receptors with high binding capacity and their application in selective photocatalysis. Journal of Materials Chemistry A, 2020, 8(48), 25931-25940. (IF=12.731, Times cited: 2)

(13) Wu, S.; Zhu, R.; Dong, Y.; Huang, C.*; Shen, X. Electromembrane extraction of barbiturates using tributyl phosphate as an efficient supported liquid membrane. Analytica Chimica Acta, 2020, 1129, 118-125. (IF=6.558, Times Cited: 4)

(14) Jiang, L.; Liu, H.; Huang, C.*; Shen, X.* Blood group antigen shielding facilitated by selective cell surface engineering. ACS Applied Materials Interfaces, 2020, 12, 22426-22432. (IF=8.758, Times cited: 3)

(15) Chen, Z.; Liu, X.; Huang, C.*; Li, J.*; Shen, X.* Artificial cytochrome c mimics: Graphene Oxide–Fe (III) complex-coated molecularly imprinted colloidosomes for selective photoreduction of highly toxic pollutants. ACS Applied Materials Interfaces, 2020, 12, 6615-6626. (IF=8.758, Times Cited: 12)

(16) Yan, Y.; Huang, C.*; Shen, X.* Electromembrane extraction of aristolochic acids: New insights in separation of bioactive ingredients of traditional Chinese medicines. Journal of Chromatography A, 2019, 1608:460424. (IF=4.759, Times Cited: 5)

(17) Liu, C.; Wu, S.; Yan, Y.; Dong, Y.; Shen, X.; Huang, C.* Application of magnetic particles in forensic science. Trends in Analytical Chemistry, 2019, 121. (IF=12.296, Times Cited: 15)

(18) Sun, X.; Liu, W.; Zhang, B.; Shen, X.; Hu, C.; Chen, X.; Jin, S.; Jiang, Y.; Liu, H.; Cao, Z.; Xia, W.; Xu, S.; Li, Y.* Maternal heavy metal exposure, thyroid hormones, and birth outcomes: A prospective cohort study. Journal of Clinical Endocrinology, Metabolism, 2019, 104(11), 5043-5052. (IF=5.958, Times Cited: 23)

(19) Wan, L.; Lin, B.; Zhu, R.; Huang, C.*; Pedersen-Bjergaard, S.; Shen, X.* Liquid-phase microextraction or electromembrane extraction. Analytical Chemistry, 2019, 91, 8267-8273. (IF=6.042, Times Cited: 21)

(20) Huang, C.*; Shen, X. (co-first author); Liu, X.; Chen, Z.; Shu, B.; Wan, L.; Liu H.; He, J.* Hybrid breath figure method: A new insight in petri dishes for cell culture. Journal of Colloid and Interface Science, 2019, 541,114-122. (IF=5.091, Times Cited: 17)

(21) Lin, B.; Wan, L.; Sun, X.; Huang, C.*; Pedersen-Bjergaard, S.; Shen, X.* Electromembrane extraction of high level substances: A novel approach for selective recovery of templates in molecular imprinting. Journal of Membrane Science, 2018, 568, 30-39. (IF=6.578, Times Cited: 15)

(22) Sun, X.; Li, J.; Jin, S.; Li, Y.; Liu, W.; Zhao, H.; Zhou, Y.; Jiang, Y.; Liu, H.; Xia, W.; Cai, Z.; Xu, S.*; Shen, X.* Associations between repeated measures of maternal urinary phthalate metabolites during pregnancy and cord blood glucocorticoids. Environmental International, 2018, 121, 471-479. (IF=7.297, Times Cited: 15)

(23) Wang, S.; Lin, B.; Chen, L.; Li, N.; Xu, J.; Wang, J.;Yan, Y,; Qi, Y.; She, Y.; Shen, X.*; Xiao, X.* Branch-migration based fluorescent probe for highly sensitive detection of mercury. Analytical Chemistry, 2018, 90(20), 11764-11769. (IF=6.042, Times Cited: 18)

(24) Sun, X.; Jiang, Y.; Xia, W.; Jin, S.; Liu, W.; Lin, X.; Chen, X.; Peng, Y.; Li, H.; Lu, B.; Xu, S.; Li, Y.*; Shen, X.* Association between prenatal nickel exposure and preterm low birth weight: Possible effect of selenium. Environmental Science and Pollution Research, 2018, 25(26), 25888-25895. (IF=2.80, Times Cited: 19)

(25) Huang, C.*; Shen, X.*; Gjelstad, A.; Pedersen-Bjergaard, S. Investigation of alternative supported liquid membranes in electromembrane extraction of basic drugs from human plasma. Journal of Membrane Science, 2018, 548, 176-183. (IF=6.578, Times Cited: 25)

(26) Huang, C.*; Chen, Z.; Gjelstad, A.; Pedersen-Bjergaard, S.; Shen, X.* Electromembrane extraction. Trends Analytical Chemistry, 2017, 95, 47-56. (IF=8.442, Times Cited: 75)

(27) Guo, Q.; Shen, X.; Li, Y.; Xu, S.* Carbon nanotubes-based drug delivery to cancer and brain. Journal of Huazhong University of Science and Technology-Medical Sciences, 2017, 37(5), 635-641. (IF=0.948, Times Cited: 55)

(28) Wan, L.; Chen, Z.; Huang, C.*; Shen, X.* Core-shell molecularly imprinted particles. Trends Analytical Chemistry, 2017, 95, 110-121. (IF= 8.442, Times Cited: 61)

(29) Chen, Z.; Sellergren, B.; Shen, X.* Synergistic catalysis by “polymeric microzymes and inorganic nanozymes”: The 1+1>2 effect for intramolecular cyclization of peptides. Frontiers in Chemiatry, 2017, 5, 60. (IF=3.994, Times Cited: 6)

(30) Restan, M.; Jensen, H.; Shen, X.; Huang, C.; Martinsen, O.; Kubáň, P.; Gjelstad, A.; Pedersen-Bjergaard, S. Comprehensive study of buffer systems and local pH effects in electromembrane extraction. Analytical Chemistry Acta, 2018, 984, 116-123. (IF=5.123, Times Cited: 38)

(31) Shen, X.*; Huang, C.; Shinde, S.; Jagadeesan, K.; Ekström, S.; Fritz, E.; Sellergren, B.* Catalytic formation of disulfide bonds in peptides by molecularly imprinted microgels at oil/water interfaces. ACS Applied Material Interfaces, 2016, 8, 30484-30491. (IF=7.504, Times Cited: 33)

(32) Shen, X.*; Huang, C.*; Shinde, S.; Switnicka-Plake, M.; Cormacke, P.; Sellergren, B. Reflux precipitation polymerization: a new synthetic insight in molecular imprinting at high temperature. RSC Advances, 2016, 6, 81491-81499. (IF=3.108, Times Cited: 12)

(33) Ye, L.*; Zhou, T.; Shen, X. Molecular imprinting in particle-stabilized emulsions: enlarging template size from small molecules to proteins and cells. Molecular Imprinting, 2016, 3(1), 8-16. (Times Cited: 8)

(34) Huang, C.; Seip, KP.; Gjelstad, A.; Shen, X.* Pedersen-Bjergaard, S. Combination of electromembrane extraction and liquid-phase microextraction in a single step: Simultaneous group separation of acidic and basic drugs. Analytical Chemistry, 2015, 87, 6951-6957. (IF=6.320, Times Cited: 40)

(35) Shen, X.; Bonde, JS.; Kamra, T.; Bülow, L.; Leo, JC.; Linke, D.; Ye, L.* Bacterial imprinting at Pickering emulsion interfaces. Angewandte Chemie-International Edition, 2014, 53, 10687-10690. (IF=13.734, Times Cited: 99)

(36) Tu, Z.; Tang, H.*; Shen, X. Particle-assisted semidirect breath figure method: A facile way to endow the honeycomb-structured Petri dish with molecular recognition capability, ACS Applied Materials  Interfaces, 2014, 6, 12931-12938. (IF=7.504, Times Cited: 16)

(37) Huang, C.; Shen, X.* Janus molecularly imprinted polymer particles. Chemical Communications, 2014, 50, 2646-2649. (IF=6.378, Times Cited: 50)

(38) Huang, C.; Shen, X.* Breath figure patterns made easy. ACS Applied Materials Interfaces, 2014, 6, 5971-5976. (IF=7.504, Times Cited: 37)

(39) Zhou, T.; Shen, X.*; Chaudhary, S.; Ye, L. Molecularly imprinted polymer beads prepared by pickering emulsion polymerization for steroid recognition. Journal of Applied Polymer Science, 2014, 131, 39606. (IF=1.395, Times Cited: 50)

(40) Shen, X.; Zhu, L.; Wang, N.*; Zhang, T.; Tang, H. Selective photocatalytic degradation of nitrobenzene facilitated by molecular imprinting with a transition state analog. Catalysis Today, 2014, 225, 164-170. (IF=2.98, Times Cited: 50)

(41) Huang, C.; Eibak, LEE.; Gjelstad, A.; Shen, X.; Trones, R.; Jensen, H.; Pedersen-Bjergaard, S.* Development of a flat membrane based device for electromembrane extraction: A new approach for exhaustive extraction of basic drugs from human plasma. Journal of Chromatography A, 2014, 1326, 7-12. (IF=4.449, Times Cited: 79)

(42) Shen, X.; Xu, C.; Uddin, KMA.; Larsson, PO.; Ye, L.* Molecular recognition with colloidosomes enabled by imprinted polymer nanoparticles and fluorogenic boronic acid. Journal of Materials Chemistry B, 2013, 1, 4612-4618. (IF=6.101, Times Cited: 27)

(43) Huang, C.; Tu, Z.; Shen, X.* Molecularly imprinted photocatalyst with a structural analogue of template and its application. Journal of Hazard Materials, 2013, 248-249, 379-386. (IF=3.925, Times Cited: 29)

(44) Xu, C.; Uddin, KMA.; Shen, X.; Jayawardena, HSH.; Yan, MD.; Ye, L.* Photoconjugation of molecularly imprinted polymer with magnetic nanoparticles. ACS Applied Materials Interfaces, 2013, 5, 5208-5213. (IF=5.008, Times Cited: 40)

(45) Shen, X.; Xu, C.; Ye, L.* Molecularly imprinted polymers for clean water: Analysis and purification. Industrial Engineering Chemistry Research, 2013, 52, 13890-13899. (IF=2.206, Times Cited: 55)

(46) Shen, X.; Zhou, T.; Ye, L.* Molecular imprinting of protein in Pickering emulsion. Chemistry Communications, 2012, 48, 8198-8200. (IF=6.378, Times Cited: 95)

(47) Shen, X.; Xu, C.; Ye, L.* Imprinted polymer beads enabling direct and selective molecular separation in water. Soft Matter, 2012, 8, 3169-3176. (IF=3.909, Times Cited: 56)

(48) Xu, C.; Shen, X. (co-first author); Ye, L.* Molecularly imprinted magnetic materials prepared from modular and clickable nanoparticles. Journal of Materials Chemistry, 2012, 22, 7427-7433. (IF=6.101, Times Cited: 36)

(49) Shen, X.; Zhu, L.*; Wang, N.; Ye, L.; Tang, H. Molecular imprinting for removing highly toxic organic pollutants. Chemistry. Communication, 2012, 48, 788-798. (IF=6.378, Times Cited: 132)

(50) Tang, H.; Zhu, L.; Yu, C.; Shen, X.* Selective photocatalysis mediated by magnetic molecularly imprinted polymers. Separation and Purification Technology, 2012, 95, 165-171. (IF=2.894, Times Cited: 35)

(51) Shen, X.; Ye, L.* Molecular imprinting in Pickering emulsions: A new insight into molecular recognition in water. Chemical Communications, 2011, 47, 10359-10361. (IF=6.378, Times Cited: 89)

(52) Shen, X.; Ye, L.* Interfacial molecular imprinting in nanoparticle-stabilized emulsions. Macromolecules, 2011, 44, 5631-5637. (IF=5.521, Times Cited: 115)

(53) Wang, N.; Xu, Y.; Zhu, L.; Shen, X.; Tang, H.* Reconsideration to the deactivation of TiO₂ catalyst during simultaneous photocatalytic reduction of Cr(VI) and oxidation of salicylic acid. Journal of Photochemistry and Photobiology A-Chemistry, 2009, 201, 121-127. (IF=2.416, Times Cited: 85)

(54) Shen, X.; Zhu, L.*; Huang, C.; Tang, H.; Yu, Z.; Deng, F. Inorganic molecular imprinted titanium dioxide photocatalyst: synthesis, characterization and its application for efficient and selective degradation of phthalate esters. Journal of Material. Chemistry, 2009, 19, 4843-4851. (IF=6.101, Times Cited: 95)

(55) Shen, X.; Zhu, L.*; Yu, H.; Tang, H.; Liu, S.; Li, W. Selective photocatalysis on molecular imprinted TiO₂ thin films prepared via an improved liquid phase deposition method. New Journal of Chemistry, 2009, 33, 1673-1679. (IF=2.966, Times Cited: 45)

(56) Shen, X.; Zhu, L.*; Liu, G.; Tang, H.; Liu, S.; Li, W. Photocatalytic removal of pentachlorophenol by means of an enzyme-like molecular imprinted photocatalyst and inhibition of the generation of highly toxic intermediates. New Journal of Chemistry, 2009, 33, 2278-2285. (IF=2.966, Times Cited: 33)

(57) Shen, X.; Zhu, L.*; Liu, G.; Yu, H.; Tang, H. Enhanced photocatalytic degradation and selective removal of nitrophenols by using surface molecular imprinted titania. Environmental Science, Technology, 2008, 42, 1687-1692. (IF=5.257, Times Cited: 191)

(58) Shen, X.; Zhu, L.*; Li, J.; Tang, H. Synthesis of molecular imprinted polymer coated photocatalysts with high selectivity. Chemical Communications, 2007, 11, 1163-1165. (IF=6.378, Times Cited: 110)

(59) Li, J.; Tang, H.*; Zhang, A.; Shen, X.; Zhu, L. A new strategy for the synthesis of polyaniline nanostructures: From nanofibers to nanowires. Macromolecular Rapid Communications, 2007, 28, 740-745. (IF=4.929, Times Cited: 50)

二、 中文文章

    (1) 江龙, 沈先涛*. 基于 Pickering 乳液的分子印迹技术. 科学通          报, 2018, 63

(2) 常青, 沈先涛, 王佳, 朱丽华. 液相微萃取-气相色谱法测定水样中痕量酚类污染物. 理化检验-化学分册 2008, 44: 11-13

三、 专著

(1) Shen, X.; Huang, C.; Ye, L., Generation of Janus Molecularly Imprinted Polymer Particles. In Synthetic Antibodies. 2017, 353-362 (Humana Press)

(2) Shen, X., Molecularly Imprinted Catalysts, Molecularly Imprinted Photocatalysts. 2016,.211-228 (Elsevier)

(3) 潘建明，潘国庆，沈先涛，现代分子印迹辨识技术[M]. 长春：吉林大学出版社，2021，ISBN：978-7-5692-9262-6，001-380.

四、 专利

(1) 沈先涛, 陈志亮, 刘小杰, 一种光还原六价铬的离子印迹聚合物材料及其制备和应用. 国家发明专利号: 2017105347996

(2) 徐顺清; 沈先涛; 陈志亮, 一种选择性分离耐药杆菌的印迹薄膜材料及其制备与应用,国家发明专利号: ZL202010760914.3

(3) 徐顺清; 沈先涛; 陈志亮; 梅航, 半互穿网络聚合物支撑膜、制备及用于电膜萃取的应用, 国家发明专利号: ZL202010974220.X

(4) 朱丽华, 沈先涛, 唐和清,人工抗体型复合光催化剂及其制备方法. 国家发明专利号: 200610019453.4

(5) 朱丽华, 罗玮, 沈先涛, 唐和清, 一种SiO2颗粒表面分子印迹吸附剂及其制备方法. 国家发明专利号: 200810046661.2