职务：华中科技大学教授，博士生导师
院系：流行病与卫生统计学系
地址：湖北省武汉市航空路13号 430030
电话：86-27-83693763
邮箱：gracefulliuly@163.com
2007年毕业于华中科技大学预防医学专业，2012年在华中科技大学同济医学院获医学博士学位。2016.1-2017.12在哈佛大学医学院Dana-Farber Cancer Institute及哈佛大学公共卫生学院做博士后研究，具有大队列数据分析及管理经验。主要研究方向：营养流行病学、肿瘤流行病学，重点关注饮食、菌群、免疫在结直肠癌发生发展中的作用。承担了国家自然科学基金、湖北省卫生健康委预防转项-重点项目、中国科协、教育部博士点课题等多项项目，作为课题骨干参与了国家重点研发项目、湖北省技术创新专项重大项目、国家自然基金重点项目等。已发表SCI论文近30篇，总IF超过200分，其中以第一作者或通讯作者在JAMA，Gastroenterology，Gut，Br J Sports Med，J Am Soc Nephrol，Clin Gastroenterol Hepatol，Eur J Epidemiol，Environ Int，Cancer等杂志上发表论文。获得湖北省科技进步二等奖（第二完成人），中国抗癌协会科技奖二等奖（第三完成人）。现担任Clinical Cancer Research，EbioMedicine等杂志的审稿人。
主要承担和参与的科研项目
2014-2016 全基因组表达相关拷贝数变异在结直肠癌发生发展中的作用及机制研究，国家自然基金青年基金 (81302491)
2014-2016 全基因组表达相关拷贝数变异在结直肠癌易感性中的作用，教育部博士点课题
2013-2014 端粒酶基因多态性、端粒长度在胆囊癌易感性中的作用，校自助创新课题(2013QN001)
2010-2015中国农村地区传染病整合监测系统：为资源匮乏地区疾病流行的早期发现收集证据，欧盟第七框架计划项目 (241900)
2015-2019线粒体动力学改变在氟神经毒性中的作用及白藜芦醇干预效果研究，国家自然基金重点项目 (81430076)
2014-2017遗传易感性和早期生活方式的交互作用在婴儿肥胖发生中的作用，国家自然基金面上项目 (81373017)
2012-2015 Wnt信号通路及其关键靶基因与结直肠癌遗传易感性的关联研究，国家自然基金面上项目 (81172752)
2012-2014 妊娠期骨骼铅动员的MTFHR、VDR基因多态性及相关因素研究，国家自然基金青年基金 (81102185)
2012-2014 钾离子信号网络基因遗传变异与注意缺陷多动障碍易感性研究，国家自然基金青年基金 (81101016)
代表性论著
1. Pan A, Liu L, Wang C, Guo H, Hao X, Wang Q, Huang J, He N, Yu H, Lin X, Wei S, Wu T. Association of Public Health Interventions With the Epidemiology of the COVID-19 Outbreak in Wuhan, China. JAMA. 2020 Apr 10;323(19):1-9. (Co-first author)
2. Xiong F, Tang H, Liu L, Tu C, Tian J, Lei C, Liu J, Dong J, Chen W, Wang X, Luo D, Shi M, Miao X and Zhang C. Clinical Characteristics of and Medical Interventions for COVID-19 in Hemodialysis Patients in Wuhan, China. J Am Soc Nephrol
. 2020 Jul;31(7):1387-1397. (Co-first author)
3. Liu L, Nishihara R, Qian ZR, Tabung FK, Nevo D, Zhang X, Song M, Cao Y, Mima K, Masugi Y, Shi Y, da Silva A, Twombly T, Gu M, Li W, Hamada T, Kosumi K, Inamura K, Nowak JA, Drew DA, Lochhead P, Nosho K, Wu K, Wang M, Garrett WS, Chan AT, Fuchs CS, Giovannucci EL, Ogino S. Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor. Gastroenterology. 2017 Dec;153(6):1517-1530.e14.
4. Yang W, Liu L, Masugi Y, Qian ZR, Nishihara R, Keum N, Wu K, Smith-Warner S, Ma Y, Nowak JA, Momen-Heravi F, Zhang L, Bowden M, Morikawa T, Silva AD, Wang M, Chan AT, Fuchs CS, Meyerhardt JA, Ng K, Giovannucci E, Ogino S, Zhang X. Calcium intake and risk of colorectal cancer according to expression status of calcium-sensing receptor (CASR). Gut. 2018 Aug;67(8):1475-1483. (co-first author)
5. Li T, Wei S, Shi Y, Pang S, Qin Q, Yin J, Deng Y, Chen Q, Wei S, Nie S, Liu L. The dose-response effect of physical activity on cancer mortality: findings from 71 prospective cohort studies. Br J Sports Med. 2016 Mar;50(6):339-45.
6. Liu L, Shi Y, Li T, Qin Q, Yin J, Pang S, Nie S, Wei S. Leisure time physical activity and cancer risk: evaluation of the WHO's recommendation based on 126 high-quality epidemiological studies. Br J Sports Med. 2016 Mar;50(6):372-8.
7. Liu L, Tabung FK, Zhang X, Nowak JA, Qian ZR, Hamada T, Nevo D, Bullman S, Mima K, Kosumi K, da Silva A, Song M, Cao Y, Twombly TS, Shi Y, Liu H, Gu M, Koh H, Li W, Du C, Chen Y, Li C, Li W, Mehta RS, Wu K, Wang M, Kostic AD, Giannakis M, Garrett WS, Hutthenhower C, Chan AT, Fuchs CS, Nishihara R, Ogino S, Giovannucci EL. Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum. Clin Gastroenterol Hepatol. 2018 Oct;16(10):1622-1631.e3.
8. Yu X, Chen J, Li Y, Liu H, Hou C, Zeng Q, Cui Y, Zhao L, Li P, Zhou Z, Pang S, Tang S, Tian K, Zhao Q, Dong L, Xu C, Zhang X, Zhang S, Liu L, Wang A. Threshold effects of moderately excessive fluoride exposure on children's health: A potential association between dental fluorosis and loss of excellent intelligence. Environ Int. 2018 Sep;118:116-124. (Co-corresponding author)
9. Hamada T, Liu L, Nowak JA, Mima K, Cao Y, Ng K, Twombly TS, Song M, Jung S, Dou R, Masugi Y, Kosumi K, Shi Y, da Silva A, Gu M, Li W, Keum N, Wu K, Nosho K, Inamura K, Meyerhardt JA, Nevo D, Wang M, Giannakis M, Chan AT, Giovannucci EL, Fuchs CS, Nishihara R, Zhang Z, Ogino S. Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour. Eur J Cancer. 2018 Sep 12;103:98-107. (co-first author)
10. Kosumi K, Hamada T, Zhang S, Liu L, da Silva A, Koh H, Twombly TS, Mima K, Morikawa T, Song M, Nowak JA, Nishihara R, Saltz LB, Niedzwiecki D, Ou FS, Zemla T, Mayer RJ, Baba H, Ng K, Giannakis M, Zhang X, Wu K, Giovannucci EL, Chan AT, Fuchs CS, Meyerhardt JA, Ogino S. Prognostic association of PTGS2 (COX-2) over-expression according to BRAF mutation status in colorectal cancer: Results from two prospective cohorts and CALGB 89803 (Alliance) trial. Eur J Cancer. 2019 Apr;111:82-93. (co-first author)
11. Liu L, Nevo D, Nishihara R, Cao Y, Song M, Twombly TS, Chan AT, Giovannucci EL, VanderWeele TJ, Wang M, Ogino S.Utility of inverse probability weighting in molecular pathological epidemiology. Eur J Epidemiol. 2018 Apr;33(4):381-392.
12. Liu L, Chen H, Li Y, Li H, Li J, Wang Y, Yao S, Qin C, Tong S, Yuan X, Luo X, Miao X, Pan A, Liu Z, Cheng L. Temporal Profiles of Antibody Responses, Cytokines, and Survival of COVID-19 Patients: A Retrospective Cohort in Wuhan, China. Engineering (Beijing). 2021 May 18. doi: 10.1016/j.eng.2021.04.015.
13. Liu L, Yuan P, Liu L, Wu C, Zhang X, Guo H, Zhong R, Xu Y, Wu J, Duan S, Rui R, Wu T, Nie S, Miao X, Lin D. A functional -77T>C polymorphism in XRCC1 is associated with risk of breast cancer. Breast Cancer Res Treat. 2011 Jan;125(2):479-87.
14. Yu X, Xia L, Zhang S, Zhou G, Li Y, Liu H, Hou C, Zhao Q, Dong L, Cui Y, Zeng Q, Wang A, Liu L. Fluoride exposure and children's intelligence: Gene-environment interaction based on SNP-set, gene and pathway analysis, using a case-control design based on a cross-sectional study. Environ Int. 2021 Jun 4;155:106681. doi: 10.1016/j.envint.2021.106681.
15. Wang K, Yu X, Jiang H, Huang J, Wang H, Jiang H, Wei S, Liu L. Genome-wide expression profiling-based copy number variations and colorectal cancer risk in Chinese. Mol Carcinog. 2019 Jul;58(7):1324-1333.
16. Liu L, Wu J, Zhong R, Wu C, Zou L, Yang B, Chen W, Zhu B, Duan S, Yu D, Tan W, Nie S, Lin D, Miao X. Multi-loci analysis reveals the importance of genetic variations in sensitivity of platinum-based chemotherapy in non-small-cell lung cancer. Mol Carcinog. 2013 Dec;52(12):923-31.
17. Pang S, Zhou Z, Yu X, Wei S, Chen Q, Nie S, Liang X, Liu L.The predictive value of integrated inflammation scores in the survival of patients with resected hepatocellular carcinoma: A Retrospective Cohort Study. Int J Surg. 2017 Jun;42:170-177.
