主要研究方向：职业流行病学、环境污染物的健康危害、机制及防控策略

二级教授，博士生导师，获国务院政府特殊津贴，科技部重点领域创新团队负责人，入选湖北省公共卫生领军人才和教育部新世纪优秀人才，是国家重点学科劳动卫生与环境卫生学学术带头人，华中学者领军岗。学术任职包括：国家卫键委职业健康标准专业委员会委员，中国职业安全健康协会呼吸防护专业技术分会副主任委员，中国卫生监督协会团体标准委员会职业病诊断标准委员会副主任委员，中华预防医学会劳动卫生与职业病分会委员会常委委员和湖北省预防医学会劳动卫生与职业病专业委员会主任委员等。国家精品课程：职业卫生与职业医学主讲教师，近年先后主持国家基础研究973课题、科技部重点研发课题、国家自然科学基金重点、面上项目、环保部行业性公益专项等多项，牵头或参与起草10余项国家职业卫生标准。2014年获国家科技进步二等奖（排名第一），2007年获湖北省科技进步一等奖（排名第一）。已发表论文300余篇，SCI收录200余篇，包括Lancet、Am J Resp Crit Care、Diabetes Care、Euro Resp J、PLoS Med、J Hazard Mater、Thorax、Chest、Environ Int等国际一流期刊。

近期相关代表作（*通讯作者）：

1. Ma J, Tan Q, Nie X, Zhou M, Wang B, Wang X, Cheng M, Ye Z, Xie Y, Wang D, Chen W*. Longitudinal relationships between polycyclic aromatic hydrocarbons exposure and heart rate variability: Exploring the role of transforming growth factor-β in a general Chinese population. J Hazard Mater. 2022 Mar 5;425:127770.

2. Liu W, Wang B, Yang S, Xu T, Yu L, Wang X, Cheng M, Zhou M, Chen W*. Associations of propylene oxide exposure with fasting plasma glucose and diabetes: Roles of oxidative DNA damage and lipid peroxidation. Environ Pollut. 2022 Jan 1;292(Pt B):118453.

3. Fan L, Li W, Ma J, Cheng M, Xie L, Ye Z, Xie Y, Wang B, Yu L, Zhou Y*, Chen W*. Benzo(a)pyrene induces airway epithelial injury through Wnt5a-mediated non-canonical Wnt-YAP/TAZ signaling. Sci Total Environ. 2022 Apr 1;815:151965.

4. Wang D, Liang R, Yang M, Ma J, Li W, Mu M, Xiao Y, Feng X, Dong C, Yu L, Liu W, Tan Q, Zhou M, Wang B, Shi T, Yuan L, Chen W*. Incidence and diseases burden of coal workers' pneumoconiosis worldwide, 1990-2019: evidence from the Global Burden of Disease Study 2019. Eur Respir J. 2021 Sep 24:2101669.

5. Wang B, Wang X, Yang S, Cheng M, Zhou Y, Zhou M, Ye Z, Qiu W, He H, Cen X, Zhu C, Cao L, Mu G, Ma J, Wang D, Xiao L, Yuan J, Chen W*. Acrylamide exposure and pulmonary function reduction in general population: The mediating effect of systemic inflammation. Sci Total Environ. 2021 Jul 15;778:146304.

6. Nie X, Mu G, Yang S, Ye Z, Wang M, Wang D, Ma J, Guo Y, Wang B, Dai W, Chen W*.  The methylation of the AMER3 gene mediates the negative association between urinary polycyclic aromatic hydrocarbon metabolites and fasting plasma glucose in non-smokers: A new clue for the development of hypoglycemic agents. J Hazard Mater. 2021 Jul 2;419:126548.

7. Wang X, Bin Wang, Zhou M, Xiao L, Xu T, Yang S, Nie X, Xie L, Yu L, Mu G, Ma J*, Chen W*. Systemic inflammation mediates the association of heavy metal exposures with liver injury: A study in general Chinese urban adults. J Hazard Mater. 2021 Jun 29;419:126497.

8. Yang M, Wang D, Gan S, Wang B, Yu L, Xie Y, Fan L, Ma J, Chen W*. Triiodothyronine ameliorates silica-induced pulmonary inflammation and fibrosis in mice. Sci Total Environ. 2021 May 26;790:148041.

9. Zhou M, Yang S, Wang X, Zhang X, Cen X, Mu G, Wang D, Ma J, Wang B, Chen W*. The association between urinary aluminum and lung function among an urban adult population: A repeated-measure longitudinal study. Chemosphere. 2021 May;270:129443.

10. Xu T, Wang B, Wang X, Yang S, Cao L, Qiu W, Cheng M, Liu W, Yu L, Zhou M, Wang D, Ma J, Chen W*. Associations of urinary carbon disulfide metabolite with oxidative stress, plasma glucose and risk of diabetes among urban adults in China. Environ Pollut. 2021 Mar 1;272:115959

11. Qiu W, He H, Zhang P, Yang W, Shi T, Wang X, Chen A, Xie L, Yang M, Wang D, Li M*, Chen W*. Effect of public health interventions on COVID-19 cases: an observational study. Thorax. 2021 Feb 16:thoraxjnl-2020-215086.

12. Mu G, Zhou M, Wang B, Cao L, Yang S, Qiu W, Nie X, Ye Z, Zhou Y, Chen W*. Personal PM2.5 exposure and lung function: Potential mediating role of systematic inflammation and oxidative damage in urban adults from the general population. Sci Total Environ. 2021 Feb 10;755(Pt 1):142522.

13. Cheng M, Zhou Y, Wang B, Mu G, Ma J, Zhou M, Wang D, Yang M, Cao L, Xie L, Wang X, Nie X, Yu L, Yuan J, Chen W*. IL-22: A potential mediator of associations between urinary polycyclic aromatic hydrocarbon metabolites with fasting plasma glucose and type 2 diabetes. J Hazard Mater. 2021 Jan 5;401:123278.

14. Zhou M, Xiao L, Yang S, Wang B, Shi T, Tan A, Wang X, Mu G, Chen W*. Cross-sectional and longitudinal associations between urinary zinc and lung function among urban adults in China. Thorax. 2020 Sep;75(9):771-779.

15. Wang B, Qiu W, Yang S, Cao L, Zhu C, Ma J, Li W, Zhang Z, Xu T, Wang X, Cheng M, Mu G, Wang D, Zhou Y, Yuan J, Chen W*. Acrylamide Exposure and Oxidative DNA Damage, Lipid Peroxidation, and Fasting Plasma Glucose Alteration: Association and Mediation Analyses in Chinese Urban Adults. Diabetes Care. 2020 Jul;43(7):1479-1486.

16. Wang B, Cheng M, Yang S, Qiu W, Li W, Zhou Y, Wang X, Yang M, He H, Zhu C, Cen X, Chen A, Xiao L, Zhou M, Ma J, Mu G, Wang D, Guo Y, Zhang X, Chen W*. Exposure to acrylamide and reduced heart rate variability: The mediating role of transforming growth factor-β. J Hazard Mater. 2020 Aug 5;395:122677.

17. Ma J, Zhou Y, Wang D, Guo Y, Wang B, Xu Y, Chen W*. Associations between essential metals exposure and metabolic syndrome (MetS): Exploring the mediating role of systemic inflammation in a general Chinese population. Environ Int. 2020 Jul;140:105802.

18. Wang D, Zhou M, Liu Y, Ma J, Yang M, Shi T, Chen W*. Comparison of risk of silicosis in metal mines and pottery factories: A 44-year cohort study. Chest. 2020；158(3):1050-1059

19. Wang D, Yang M, Liu Y, Ma J, Shi T, Chen W*. Association of Silica Dust Exposure and Cigarette Smoking With Mortality Among Mine and Pottery Workers in China. JAMA Netw Open. 2020 Apr 1;3(4):e202787.

20. Zhou Y, Ma J, Wang B, Liu Y, Xiao L, Ye Z, Fan L, Wang D, Mu G, Chen W*. Long-term effect of personal PM2.5 exposure on lung function: A panel study in China. J Hazard Mater. 2020 Mar 3;393:122457.

21. Zhang Z, Zhou M, He J, Shi T, Zhang S, Tang N, Chen W*. Polychlorinated dibenzo-dioxins and polychlorinated dibenzo-furans exposure and altered lung function: The mediating role of oxidative stress. Environ Int. 2020 Apr;137:105521.

22. Zhou M, Yang S, Guo Y, Wang D, Qiu W, Wang B, Mu G, Cao L, Zhang Z, Chen W*. Shift work and the risk of knee osteoarthritis among Chinese workers: a retrospective cohort study. Scand J Work Environ Health. 2020 Mar 1;46(2):152-160.

23. Zhu C, Wang B, Xiao L, Guo Y, Zhou Y, Cao L, Yang S, Chen W*. Mean platelet volume mediated the relationships between heavy metals exposure and atherosclerotic cardiovascular disease risk: A community-based study. Eur J Prev Cardiol. 2020 May;27(8):830-839.

24. Li W, Xie L, Ma J, Yang M, Wang B, Xu Y, Fan L, Mu G, Shi T*, Chen W*. Genetic loss of Gas6/Mer pathway attenuates silica-induced lung inflammation and fibrosis in mice. Toxicol Lett. 2019 Oct 1;313:178-187.

25. Ma J, Zhou Y, Liu Y, Xiao L, Cen X, Li W, Guo Y, Kim M, Yuan J, Chen W*. Association between urinary polycyclic aromatic hydrocarbon metabolites and dyslipidemias in the Chinese general population: A cross-sectional study. Environ Pollut. 2019 Feb;245:89-97.

26. Guo Y, Cao L, Zhou Y, Xiao L, Zhang X, Yuan J, Chen W*. Cardiometabolic traits mediated the relationship from urinary polycyclic aromatic hydrocarbons metabolites to heart rate variability reduction: A community-based study. Environ Pollut. 2018 Dec;243(Pt A):28-36.

27. Zhou Y, Mu G, Liu Y, Xiao L, Ma J, Wang B, Shi T, Tan A, Yuan J, Chen W*. Urinary polycyclic aromatic hydrocarbon metabolites, Club cell secretory protein and lung function. Environ Int. 2018 Feb; 111:109-116.

28. Liu Y, Zhou Y, Hnizdo E, Shi T, Steenland K, He X, Chen W*. Total and cause-specific mortality risk associated with low-level exposure to crystalline silica: a 44-year cohort study from China. Am J Epidemiol, 2017,186(4):481-490.

29. Zhou Y, Sun H, Xie J, Song Y, Liu Y, Huang X, Zhou T, Rong Y, Wu T, Yuan J*, Chen W*. Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Altered Lung Function in Wuhan, China. Am J Resp Crit Care. 2016,193(8): 835-846

30. Guo J, Shi T, Cu X, Rong Y, Zhou T, Zhang Z, Liu Y, Shen Y, Chen W*. Effects of silica exposure on the cardiac and renal inflammatory and fibrotic response and the antagonistic role of interleukin-1 beta in C57BL/6 mice. Arch Toxicol. 2016, 90 (2): 247-258