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李媛媛

 

姓名:李媛媛


职务:教授、博士生导师

地址:湖北省武汉市航空路13 430030

邮箱:liyuanyuan@hust.edu.cn

                  78DC

  

  20077月毕业于华中科技大学,获博士学位,博士学位论文获全国百篇优秀博士学位论文提名奖。2010年任副教授,2012年任博士生导师。2007年和2008年以访问学者身份赴德国图宾根大学,2015年至2016年赴美国布朗大学开展科研合作工作。Environment International等多个国际杂志审稿人。2007年获湖北省自然科学二等奖(第2名),2008年获教育部自然科学二等奖(第2名)。主要研究方向:环境流行病学、环境毒理学,重点关注胚胎期和儿童期暴露的健康效应及机制。已发表SCI收录论文40余篇。

  

  主要负责的科研项目

  1. 题目:孕期大气细颗粒物暴露对胎盘神经发育关键基因的表观遗传调控及与儿童认知能力的关联 经费来源:国家自然科学基金重大研究计划 时间:2018.1.1-2020.12.31,直接经费75万元

  2. 题目:大气污染对妊娠期妇女的影响及其对妊娠期高血压疾病的风险研究 经费来源:国家重点研发计划项目 时间:2016.07-2019.06200万元。

  3. 题目:双酚A胚胎期暴露对胰岛β细胞发育的影响及与成年后糖代谢异常的关系,国家自然科学基金项目211770462012.01-2014.1230万元。

  4. 题目:双酚A胚胎期暴露对Th2Treg细胞分化表观遗传调控的影响及其与0-3岁儿童哮喘的关系 经费来源:国家自然科学基金项目 时间:2014.01-2017.1270万元。

  5. 题目:基于纳米金双层类脂膜的环境雌激素快速筛检传感器研究 经费来源:武汉市青年科技晨光计划 时间:2012.01-2013.125万元。

  6. 题目:妊娠期烷基酚暴露对胎盘-HPA轴糖皮质激素信号的影响及与婴幼儿追赶生长的关系 经费来源:中央高校基本科研基金 时间:2016.04-2018.1260万元。

  7. 发育期环境内分泌干扰物暴露与婴幼儿神经行为障碍关系的队列研究经费来源:中央高校基本科研基金 时间:2012.01-2013.1215万元

  8. 题目:纳米双层类脂膜生物传感器检测抗生素残留研究 经费来源:国家自然科学基金 时间:2009.1-2011.1219万元。

  9. 基于优先控制化学污染物监测数据的健康危害评价技术研究,国家环境保护部公益性项目,2009.9-2012.851万元。


主要著作或论文:

1. Wenyu Liu, Bin Zhang, Zheng Huang, Xinyun Pan, Xiaomei Chen, Chen Hu, Hongxiu Liu, Yangqian Jiang, Xiaojie Sun, Yang Peng, Wei Xia, Shunqing Xu, and Yuanyuan Li*, Cadmium Body Burden and Gestational Diabetes Mellitus: a Prospective Study. Environ Health Perspect. 2018 Feb 8;126(2):027006. doi: 10.1289/EHP2716.

2. Yuling Xing, Wei Xia, Bin Zhang, Aifen Zhou, Zheng Huang, Hongling Zhang, Hongxiu Liu, Yangqian Jiang, Chen Hu, Xiaomei Chen, Shunqing Xu, and Yuanyuan Li*, Relation between cadmium exposure and gestational diabetes mellitus. Environ Int. 2018 Jan 12. pii: S0160-4120(17)31866-4. doi: 10.1016/j.envint.2018.01.001.

3. Hongxiu Liu, Shi Lu, Bin Zhang, Wei Xia, Wenyu Liu, ang Peng, Hongling Zhang, Kangbing Wu, Shunqing Xu, Yuanyuan Li*. Maternal arsenic exposure and birth outcomes: A birth cohort study in Wuhan, China. Environ Pollut. 2018 Feb 17; 236:817-823. doi: 10.1016/j.envpol.2018.02.012.

4. Hongxiu Liu, Wei Xia, Shunqing Xu, Bin Zhang, Bin lu, Zheng Huang, Hongling Zhang, Yangqian Jiang, Wenyu Liu, Yang Peng, Xiaojie Sun, Yuanyuan Li*, Cadmium body burden and pregnancy-induced hypertension. Int J Hyg Environ Health. 2017 Nov 18. pii: S1438-4639(17)30533-3. doi: 10.1016/j.ijheh.2017.11.001.

5. Wenqian Huo, Wei Xia, Chuansha Wu, Yingshuang Zhu, Bin Zhang, Yanjian Wan, Aifen Zhou, Zhengmin Qian, Zhong Chen, Yangqian Jiang, Hongxiu Liu, Jie Hu, Bing Xu, Shunqing Xu, Yuanyuan Li*, Urinary level of triclosan in a population of Chinese pregnant women and its association with birth outcomes. Environ Pollut, 2017 Oct 4. pii: S0269-7491(16)31554-8.,  DOI: 10.1016/j.envpol.2017.08.073

6. Yangqian Jiang, Wei Xia, Bin Zhang, Xinyun Pan, Wenyu Liu, Shuna Jin, Wenqian Huo, Hongxiu Liu, Yang Peng, Xiaojie Sun, Hongling Zhang, Aifen Zhou, Shunqing Xu, Yuanyuan Li*. Predictors of thallium exposure and its relation with preterm birth. Environ Pollut. 2017 Oct 12. pii: S0269-7491(17)32797-5, DOI:10.1016/j.envpol.2017.09.080.

7. Lu Cheng, Bin Zhang, Wenqian Huo, Zhongqiang Cao, Wenyu Liu, Jiaqiang Liao, Wei Xia, Shunqing Xu, Yuanyuan Li*. Fetal exposure to lead during pregnancy and the risk of preterm and early-term deliveries. Int J Hyg Environ Health, 2017. 220(6): p. 984-989.

8. Xinyun Pan, Jie Hu, Wei Xia, Bin Zhang , Wenyu Liu, Chuncao Zhang, Jie Yang, Chen Hu, Aifen Zhou, Zhong Chen, Jingxia Cao, Yiming Zhang, Youjie Wang, Zheng Huang, Bin Lv, Ranran Song, Jianduan Zhang, Shunqing Xu, Yuanyuan Li,*. Prenatal chromium exposure and risk of preterm birth: a cohort study in Hubei, China. Sci Rep, 2017. 7(1): p. 3048

9. Yingshuang Zhu, Yanjian Wan, Bin Zhang, Aifen Zhou, Huowen Qian, Chuansha Wu, Hongxiu Liu, Yangqian Jiang, Zong Chen, Minmin Jiang, Yang Peng, Shunqing Xu, Wei Xia* and Yuanyuan Li*. Relationship between maternal phthalate exposure and offspring size at birth. Science of the Total Environment, 2018. 612: p. 1072-1078

10. Aifen Zhou, Huailong Chang, Wenqian Huo, Bin Zhang, Jie Hu, Wei Xia, Zhong Chen, Chao Xiong, Yaqi Zhang, Youjie Wang, Shunqing Xu. Yuanyuan Li*. Prenatal exposure to bisphenol A and risk of allergic diseases in early life. Pediatric Research, 81.6(2017).

11. Jie Hu, Wei Xia, Xinyun Pan, Tongzhang Zheng, Bin Zhang, Aifen Zhou, Stephen L Buka, Bryan A Bassig, Wenyu Liu, Chuansha Wu, Yang Peng, Jun Li, Chuncao Zhang, Hongxiu Liu, Minmin Jiang, Youjie Wang, Jianduan Zhang, Zheng Huang, Dan Zheng, Kunchong Shi, Zhengmin Qian, Yuanyuan Li*, Shunqing Xu*. Association of adverse birth outcomes with prenatal exposure to vanadium: a population-based cohort study. Lancet Planet Health 2017; 1: e230–41

12. Lu Cheng, Bin Zhang, Tongzhang Zheng, Aifen Zhou, Bryan A Bassig, David A Savitz, Stephen Buka, Chao Xiong, Joseph M Braun, Yaqi Zhang, Yanqiu Zhou, Xinyun Pan, Chuansha Wu, Youjie Wang, Zhengmin Qian, Aimin Yang, Megan E Romano, Kunchong Shi, Shunqing Xu, Yuanyuan Li*. Critical Windows of Prenatal Exposure to Cadmium and Size at Birth. International Journal of Environmental Research and Public Health, 2017. 14(1).

13. Han Li, Mu Wang, Qiande Liang, Shuna Jin, Xiaojie Sun, Yangqian Jiang, Xin yun Pan, Yanqiu Zhou, Yang Peng, Bin Zhang, Aifen Zhou, Yiming Zhang, Zhong Chen, Jiangxia Cao, Hongling Zhang, Wei Xia, Tongzhang Zheng, Zongwei Cai, Yuanyuan Li*, Shunqing Xu*. Urinary metabolomics revealed arsenic exposure related to metabolic alterations in general Chinese pregnant women. Journal of Chromatography A, 2017. 1479: p. 145-152

14. Zhenxing Mao, Wei Xia, Wenqian Huo, Tongzhang Zheng, Bryan A. Bassigc, Huailong Changb, Tian Chenb,d, Feie Lib, Yunxin Pan, Yang Pengb, Yuanyuan Li* and Shunqing Xu*. Pancreatic impairment and Igf2 hypermethylation induced by developmental exposure to bisphenol A can be counteracted by maternal folate supplementation. J. Appl. Toxicol. 2017; 37: 825–835

15. Huailong Chang, Danqi Wang, Wei Xia, Xinyun Pan, Wenqian Huo, Yuanyuan Li* and Shunqing Xu*. Epigenetic disruption and glucose homeostasis changes following low-dose maternal bisphenol A exposure. Toxicol. Res., 2016, DOI: 10.1039/c6tx00047a

16. Huailong Chang,† Mu Wang,† Wei Xia, Tian Chen, Wenqian Huo, Zhenxing Mao, Yingshuang Zhu, Yuanyuan Li* and Shunqing Xu*. Perinatal exposure to low-dose bisphenol A disrupts learning/memory and DNA methylation of estrogen receptor alpha in the hippocampus. Toxicol Res, 2016, 5, 828.

17. Wenqian Huo, Wei Xia, Yanjian Wan, Bin Zhang, Aifen Zhou, Yiming Zhang, Kai Huang, Yingshuang Zhu, Chuansha Wu, Yang Peng, Minmin Jiang, Jie Hua, Huailong Chang, Bing Xu, Yuanyuan Li*, Shunqing Xu*. Maternal urinary bisphenol A levels and infant low birth weight: A nested case-control study of the Health Baby Cohort in China. Environ Int. 2015 Sep 15;85:96-103.

18. Zhenxing Mao, Wei Xia, Huailong Chang, Wenqian Huo, Yuanyuan Li*, Shunqing Xu*. Paternal BPA exposure in early life alters Igf2 epigenetic status in sperm and induces pancreatic impairment in rat offspring. Toxicol lett. 2015 Nov 238(3):30-38.

19. Han Li, Bing Xu, Danqi Wang, Yin Zhou, Hongling Zhang, Wei Xia, Shunqing Xu, Yuanyuan Li*. Immunosensor for trace penicillin G detection in milk based on supported bilayer lipid membrane modified with gold nanoparticles. J Biotechnol. 2015 Jun 203:97-103.

20. Ying Jiang, Wei Xia, Jie Yang, Yingshuang Zhu, Huailong Chang, Juan Liu, Wenqian Huo, Bing Xu, Xi Chen, Yuanyuan Li*, Shunqing Xu*. BPA-induced DNA hypermethylation of the master mitochondrial gene PGC-1alpha contributes to cardiomyopathy in male rats. Toxicology. 2015 Mar 2;329:21-31.

21. Genqi Li, Huailong Chang, Wei Xia, Zhenxing Mao, Yuanyuan Li*, Shunqing Xu*. F0 maternal BPA exposure induced glucose intolerance of F2 generation through DNA methylation change in Gck. Toxicol Lett. 2014 Aug 4;228(3):192-9.

22. Ying Jiang, Wei Xia, Yingshuang Zhu, Xiaocui  Li, Danqi Wang, Juan Liu, Huailong Chang, Genqi Li, Bing Xu, Xi Chen, Yuanyuan Li*, Shunqing Xu*. Mitochondrial dysfunction in early life resulted from perinatal bisphenol A exposure contributes to hepatic steatosis in rat offspring. Toxicol Lett. 2014 Jul 15;228(2):85-92.

23. Yue Ma, Wei Xia, Danqi Wang, Yanjian Wan, Bing Xu, Xi Chen, Yuanyuan Li*, Shunqing Xu*. Hepatic DNA methylation modifications in early development of rats resulting from perinatal BPA exposure contribute to insulin resistance in adulthood. Diabetologia, 2013, 56(9): 2059-2067.

24. Zhengzheng Wei, Liqiong Song, Jie Wei, Tian Chen, Jun Chen, Yi Lin, Wei Xia, Bing Xu, Xuguang Li, Xi Chen, Yuanyuan Li*, Shunqing Xu*. Maternal exposure to di-(2-ethylhexyl)phthalate alters kidney development through the renin-angiotensin system in offspring. Toxicol Lett, 2012, 212(2):212-21.

25. Yuanyuan Li#, Tian Chen#, Yanjian Wan, Shunqing Xu*. Lead exposure in pheochromocytoma cells induces persistent changes in amyloid precursor protein gene methylation patterns. Environ Toxicol, 2012, 27(8):495-502.

26. Ling Zhang#, Yuanyuan Li#, Tian Chen, Wei Xia, Ying Zhou, Yanjian Wan, Ziquan Lv, Gengqi Li, Shunqing Xu*. Abnormal development of motor neurons in perfluorooctane sulphonate exposed zebrafish embryos. Ecotoxicology, 2011, 20(4):643-52.

27. Tian Chen#, Yuanyuan Li#, J Zhang, Bing Xu, Yi Lin, Chunxiang Wang, Yanjian Wan, Shunqing Xu*. Protective effect of C(60)-methionine derivate on lead-exposed human SH-SY5Y neuroblastoma cells. J Appl Toxicol, 2011, 31(3):255-61.

28. Huaicai Zeng#, Yuanyuan Li#, Ling Zhang, Yanjian Wan, J Chen, Wei Xia, Yi Lin, Jie Wei, Ziquan Lv, Miao Li, Shunqing Xu*. Prenatal exposure to perfluorooctanesulfonate in rat resulted in long-lasting changes of expression of synapsins and synaptophysin. Synapse, 2011, 65(3):225-33.

29. Yuanyuang Li, Hermann J Schluesene, Shunqing Xu*, Gold nanoparticle-based biosensors. Gold bulletin, 2010, 43(1): 29-41.

30. Yan-jian Wan#, Yuan-yuan Li#, Wei Xia, Jun Chen, Zi-quan Lv, Huai-cai Zeng, Ling Zhang, Wen-jie Yang, Tian Chen, Yi Lin, Jie Wei, Shun-qing Xu*. Alterations in tumor biomarker rGSTP gene methylation patterns induced by prenatal exposure to PFOS. Toxicology, 2010, 274: 57-64.

31. Wei Xia#, Yuanyuan Li#, Yanjian Wan, Tian Chen, Jie Wei, Yi Lin, Shunqing Xu*. Electrochemical biosensor for estrogenic substance using lipid bilayers modified by Au nanoparticles. Biosens and Bioelectron, 2010, 25(10):2253-8.

32. Yuanyuan Li, Zhifei Chen, Hongling Zhang, Xiaobo Li,  Jie Shen, Shi Lu, Shunqing Xu*. Inhibition of inositol-1-phosphate synthetase in Mycobacterium tuberculosis by chitosan-antisense nanoparticles. J Wuhan University of Technology-Materials Science Edition, 2009, 24(1):87-90.

33. Chi Zhang#, Yuan-Yuan Li#, Xian-Liang Wang, Li-Jun Zhang, Xiao-Bo Li, You-Jie Wang, Shun-Qing Xu*. High-throughput identification of mutations using a combination of CEL I fragmentation and SAGE technology. Genetic Test Mol Biomarkers, 2009, 13(1): 97–103.

34. Yuan-Yuan Li, Chi Zhang, Bo-Sheng Li, Li-Fan Zhao, Xiao-bo Li, Jie Shen, Shun-Qing Xu*. Ultrasensitive densitometry detection of cytokines with nanoparticle-modified aptamers. Clin Chem, 2007; 53(6):1061-6.

35. Yuan-Yuan Li, Zhi-Fei Chen, Xiao-Bo Li, Hong-Ling Zhang, Qiang Huang, Ying Zhang, Shun-Qing Xu*.  Inositol-1-phosphate synthetase mRNA as a new target for antisense inhibition of Mycobacterium tuberculosis. J Biotechnol, 2007 128(4): 726-34.