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常江

  • 中文简历English resume

  • 姓名:常江


  • 职务:副教授

  • 院系:公共卫生学院

  • 地址:湖北省武汉市航空路13号 430030

  • 电话:Fax: 86-27-83650744

  • 邮箱:changjiang815@hust.edu.cn


    1986年8月出生, 2009年毕业于南开大学生物科学专业,2014年获得中国医学科学院肿瘤学博士学位,师从著名肿瘤学专家林东昕院士。2014年7月至今,在华中科技大学同济医学院公共卫生学院工作。


主要研究领域

    肿瘤及其他慢性非传染性疾病的分子流行病学。通过大规模、多中心的人群和分子生物学研究,揭示了食管癌、胰腺癌和结直肠癌等恶性肿瘤易感基因和基因-环境交互作用,为肿瘤的防治提供了新的线索和依据。截至2018年,以第一作者或通讯作者在包括Nat Genet, Nat Commun, Cancer Res, Carcinogenesis等国内外权威期刊发表论文10余篇。目前主要的研究方向为寻找消化系统肿瘤的易感新基因、基因-环境交互作用,以及通过前瞻性队列研究探索恶性肿瘤的分子预测模型。


代表性论著

1. Chang J#, Zhong R#, Tian J#, Li J#, et al. Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma. Nat Genet 50, 338-343 (2018).


2. Chang J#, Tian J#, Zhu Y#, Zhong R#, et al. Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations. Nat Commun 9, 3688 (2018)


3. Yang Y, et al, Chang J*, Miao X*. AWESOME: A database of SNPs that affect protein post-translational modifications. Nucleic Acids Research (2018). (*Corresponding author)


4. Chang J#, Tian J#, Yang Y#, Zhong R#, et al. A rare missense variant in TCF7L2 associates with colorectal cancer risk by interacting with a GWAS-identified regulatory variant in the MYC enhancer. Cancer Res 78(17), 5164-5172 (2018).


5. Chang J#, Tan W#, Ling Z#, Xi R#, Shao M#, Chen M#, et al. Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations. Nat Commun 8, 15290 (2017).


6. Li J, Wang Y, et al, Zhong R* & Chang J*. Breast cancer risk-associated variants at 6q25.1 influence risk of hepatocellular carcinoma in a Chinese population. Carcinogenesis 38, 447-454 (2017). (*Corresponding author)


7. Chang J#, Wei L#, et al. Two novel variants on 13q22.1 are associated with risk of esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 24, 1774-80 (2015).


8. Chang J, et al. Risk prediction of esophageal squamous-cell carcinoma with common genetic variants and lifestyle factors in Chinese population. Carcinogenesis 34, 1782-6 (2013).


9. Tan D E#, Foo J N#, Bei J X#, Chang J#, et al. Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population. Nat Genet 45, 804-7 (2013).


10. Wu C#, Kraft P#, Zhai K#, Chang J#, et al. Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Nat Genet 44, 1090-7 (2012).