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严红

  • 中文简历English resume

  • 姓名:严红


  • 职务:教授,博士生导师

  • 院系:卫生毒理学系

  • 地址:湖北省武汉市航空路13号 430030

  • 邮箱:yanhong@mails.tjmu.edu.cn

    

    1987~1992同济医科大学,环境医学专业,医学学士。

    1992~1995同济医科大学,卫生毒理专业,医学硕士。

    1995~1998同济医科大学劳动卫生与环境卫生专业,医学博士。

    1998,7~至今:华中科技大学同济医学院卫生毒理学系,讲师,副教授,教授

    2007,11~2008,12美国宾夕法尼亚大学,访问学者。

    

    自1998年参加工作以来一直从事卫生毒理学和环境毒理学的教学与科研工作,2004年获华中科技大学青年教师教学竞赛三等奖,2013和2005年度华中科技大学教学质量二等奖,指导的本科生毕业论文获2014年湖北省优秀学士学位论文奖。主要从事外源性化合物的毒性作用及其分子机制研究。参加国家自然科学基金重点项目,先后主持国家自然科学基金面上项目、青年基金、教育部留学回国启动基金、中央高校自主创新研究基金、湖北省自然科学基金、武汉市科技计划项目等研究课题,完成数十项农药农药毒理学安全性评价项目。以通讯作者发表论文近30篇(SCI收录论文14篇),2001年获湖北省自然科学三等奖(排名第4)。兼任中国毒理学会生化与分子毒理学专业委员会委员,神经毒理学专委会委员,毒理学教育专委会委员,遗传毒理专委会委员,湖北省毒理学会常务理事。


主要研究领域

     探讨环境化学物的毒性作用与机制,致力于食品加工副产物和农药残留与神经退行性疾病以及糖、脂代谢紊乱的关系研究。


代表性论著

   

1.Dandan Yan, Jianling Yao,Ying Liu, Xing Zhang, Yiqi Wang, Xiaoyi Chen, Liegang Liu, Nian Shi, Hong Yan*. Tau hyperphosphorylation and P-CREB reduction are involved in acrylamide-induced spatial memory impairment: Suppression by curcumin.  Brain, Behavior, and Immunity. 2018, 71: 66-80



2. Xiaoqi Pan, Xu Wu, Dandan Yan, Cheng Peng, Chaolong Rao, Hong Yan*. Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: Involvement of the crosstalk between Nrf2 and NF-κB pathways regulated by MAPKs.  Toxicology Letters.2018,288:55-64



3. Dandan Yan, Yunjian Zhang, Liegang Liu, Nian Shi, Hong Yan*. Pesticide exposure and risk of Parkinson's disease: Dose-response meta-analysis of observational studies. Regulatory Toxicology and Pharmacology. 2018, 96:57-63



4. Dandan Yan, Xiaoqi Pan,Jianling Yao, Dun Wang, Xu Wu, Xiaoyi Chen, Nian Shi, Hong Yan*. MAPKs and NF-κB mediated acrylamide-induced neuropathy in rat striatum and human neuroblastoma cells SY5. Journal of Cellular Biochemistry. 2018, DOI:10.1002/jcb.27671



5. Xiaoqi Pan, Dandan Yan, Dun Wang, Xu Wu, Wanyun Zhao, Qing Lu, Hong Yan*. Mitochondrion-mediated apoptosis induced by Acrylamide is regulated by a balance between Nrf2 antioxidant and MAPK signaling pathways in PC12 Cells.  Molecular Neurobiology. 2017; 54(6):4781-4794



6. Dandan Yan, Yunjian Zhang, Liegang Liu, Hong Yan*. Pesticide exposure and risk of Alzheimer’s disease: a systematic review and meta-analysis. Scientific Reports .2016, Sep 1;6:32222 | DOI: 10.1038/srep32222



7. Xiaoqi Pan, Lanlan Zhu, Huiping Lu, Dun Wang, Qing Lu, Hong Yan*. Melatonin attenuates oxidative damage induced by Acrylamide in vitro and in Vivo. Oxidative Medicine and Cellular Longevity .2015;2015:703709. DOI:10.1155/2015/703709



8.Xiaoqi Pan, XiongxiongGuo, FeiXiong, Guihong Cheng, Qing Lu*, Hong Yan* . Acrylamide increases dopamine levels by affecting dopamine transport and metabolism related genes in the striatal dopaminergic system. Toxicology Letters.2015,236:60-68,



9 .Miao Yu, Di Wang , Wei Yang, Mengjing Xu, Yang Liu ,Siyuan Xu,, Ping Yao,Hong Yan*, Liegang Liu*. Mechanisms of Nrf2/HO-1 pathway up-regulation induced by pu-erh black tea extract supplementation for quinocetone-treated Sprague-Dawley rats. Journal of functional foods. 2015:14:767-778,



10. Hui Gao, Di Wang, Shun Zhang, Mengjing Xu, Wei Yang, Peipei Yan, Yang Liu, Xiao Luo, Hailei Wu, Ping Yao, Hong Yan*, Liegang Liu*.  Roles of ROS mediated oxidative stress and DNA damage in 3-methyl-2-quinoxalin benzenevinylketo-1, 4-dioxide-induced immunotoxicity of Spraguee-Dawley rats.  Regulatory Toxicology and Pharmacology.2015, 73: 587-594



11.Wei Yang, Juan Fu , Miao Yu,Di Wang,Ying Rong,Ping Yao,Andreas K. Nüssler,Hong Yan*,Liegang Liu*. Effects of Three Kinds of Curcuminoidson Anti-Oxidative System and Membrane Deformation of Human Peripheral Blood Erythrocytes in High Glucose Levels, Cellular   Physiology and Biochemistry. 2015,35:789-802



12.Wei Yang, Miao Yu, Juan Fu, Wei Bao, Di Wang, Liping Hao, Ping Yao, Andreas K. Nüssler, Hong Yan*.Liegang Liu*. Deoxynivalenol induced oxidative stress and genotoxicity in human peripheral blood lymphocytes. Food and Chemical Toxicology. 2014,64: 383–396



13. Miao Yu, Di Wang , Mengjing Xu, Yang Liu , Xia Wang , Jun Liu , Xuefeng Yang , Ping Yao,Hong Yan*, Liegang Liu*. Quinocetone-induced Nrf2/HO-1 pathway suppression aggravates hepatocyte damage of Sprague–Dawley rats. Food and Chemical Toxicology. 2014,69:210–219



14.Di Wang, Xiao Luo, Ying Zhong, Wei Yang, Mengjing Xu, Yang Liu, Jie Meng ,Ping Yao, Hong Yan * , Liegang Liu *.  Pu-erh black tea extract supplementation attenuates the oxidative DNA damage and oxidative stress in Sprague–Dawley rats with renal dysfunction induced by subchronic 3-methyl-2-quinoxalin benzenevinylketo-1,4-dioxide exposure.  Food and Chemical Toxicology. 2012,50: 147–154