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张舜

  • 中文简历English resume
  • 姓名:张舜
  • 职务:讲师,硕士生导师
  • 院系:劳动卫生与环境卫生学系
  • 地址:湖北省武汉市航空路13号 430030
  • 电话:
  • 邮箱:zs-by2005@163.com

2004/09-2009/06 华中科技大学同济医学院公共卫生学院,预防医学,学士学位;2009/09-2014/06 华中科技大学同济医学院公共卫生学院,劳动卫生与环境卫生学,推荐免试,硕博连读,博士学位,导师王爱国教授。目前主持国家自然科学基金、省部级和校级项目5项,参与国家自然科学基金重点和面上项目3项;参编专著《燃煤污染型地方性氟中毒》一部,发表SCI收录论文10余篇。现担任中国最大的公共卫生论坛—公卫人(www.epiman.cn)劳卫环卫版块版主,以及SCI期刊Environ Toxicol,Oncol Lett等杂志审稿人。

 

主要研究方向和兴趣

我们的研究主要集中在外源性化合物的毒性作用及其分子机制上面。目前主要从事环境污染物(氟和溴化阻燃剂)暴露所致的发育神经毒性和生殖毒性作用及其分子机制研究。通过构建动物和细胞染毒模型,利用化学药物及基因修饰等手段,采用先进的分子生物学技术,结合人群流行病学调查,深入探讨相关的毒性作用机制。我们的研究结果将为环境污染物致健康损害的预防控制提供依据。

 

主要负责的科研项目

1. 线粒体融合/分裂失衡在PBDE-47神经毒性中的作用,国家自然科学基金青年基金,2016-2018,18.0万元,课题负责人

 

2. 线粒体自噬在PBDE-47神经毒性中的作用及白藜芦醇干预,中国博士后科学基金(特别资助项目),2016-2017,15.0万元,课题负责人

 

3. SIRT1介导的线粒体自噬在PBDE-47神经毒性中的作用,中国博士后科学基金(面上一等资助项目),2015-2016,8.0万元,课题负责人

 

4. 线粒体融合/分裂失衡在氟神经毒性中的作用,湖北省自然科学基金青年基金,2015-2016,5.0万元,课题负责人

 

5. 线粒体融合与分裂动态失衡在PBDE-47神经毒性中的作用,华中科技大学自主创新基金,2015-2016,5.0万元,课题负责人

 

参与的科研项目

1. 线粒体动力学改变在氟神经毒性中的作用及白藜芦醇干预效果研究,国家自然科学基金重点项目,2015.1-2019.12,320.0万元,参与

 

2. 自噬与凋亡在PBDE-47神经毒性中的作用研究,国家自然科学基金面上项目,2013.1-2016.12,70.0万元,参与

 

代表性论著

#第一作者,*通讯作者

1. Zhang S, Niu Q, Gao H, Ma R, Lei R, Zhang C, Xia T, Li P, Xu C, Wang C, Chen J, Dong L, Zhao Q, Wang A*. Excessive apoptosis and defective autophagy contribute to developmental testicular toxicity induced by fluoride. Environ Pollut. 2016, 212: 97-104.

 

2. Zhang S, Chen Y, Wu X, Gao H, Ma R, Jiang C, Kuang G, Zhao G, Xia T, Zhang X, Lei R, Zhang C, Li P, Xu C, Wang A*. The Pivotal Role of Ca2+ Homeostasis in PBDE-47-Induced Neuronal Apoptosis. MolNeurobiol. 2015Dec 17. [Epub ahead of print]

 

3. Zhang S#, Zhang X#, Liu H, Qu W, Guan Z, Zeng Q, Jiang C, Gao H, Zhang C, Lei R, Xia T, Wang Z, Yang L, Chen Y, Wu X, Cui Y, Yu L, Wang A*. Modifying Effect of COMT Gene Polymorphism and a Predictive Role for Proteomics Analysis in Children’s Intelligence in Endemic Fluorosis Area in Tianjin, China. Toxicol Sci. 2015, 144(2): 238-245.

 

4. Zhang S#, Jiang C#, Liu H, Guan Z, Zeng Q, Zhang C, Lei R, Xia T, Gao H, Yang L, Chen Y, Wu X, Zhang X, Cui Y, Yu L, Wang Z, Wang A*. Fluoride-elicited developmental testicular toxicity in rats: Roles of endoplasmic reticulum stress and inflammatory response. ToxicolAppl Pharm. 2013, 271(2): 206-215.

 

5. Zhang S#, Kuang G#, Zhao G, Wu X, Zhang C, Lei R, Xia T, Chen J, Wang Z, Ma R, Li B, Yang L, Wang A*. Involvement of the mitochondrial p53 pathway in PBDE-47-induced SH-SY5Y cells apoptosis and its underlying activation mechanism. Food ChemToxicol. 2013, 62: 699-706.

 

6. Jiang C#, Zhang S#, Liu H, Guan Z, Zeng Q, Zhang C, Lei R, Xia T, Wang Z, Yang L, Chen Y, Wu X, Zhang X, Cui Y, Yu L, Wang A*. Low Glucose Utilization and Neurodegenerative Changes Caused by Sodium Fluoride Exposure in Rat’s Developmental Brain. Neuromol Med. 2014, 16(1): 94-105.

 

7. Jiang C#, Zhang S#, Liu H, Zeng Q, Xia T, Chen Y, Kuang G, Zhao G, Wu X, Zhang X, Wang A*. The role of the IRE1 pathway in PBDE-47-induced toxicity in human neuroblastoma SH-SY5Y cells in vitro. Toxicol Lett. 2012, 211(3): 325-333.

 

8. Wang C, Zhang S, Ma R, Zhang X, Zhang C, Li B, Niu Q, Chen J, Xia T, Li P, Zhao Q, Dong L, Xu C, Wang A*. Roles of endoplasmic reticulum stress, apoptosis and autophagy in 2,2′,4,4′-tetrabromodiphenyl ether-induced rat ovarian injury. ReprodToxicol. 2016, 65: 187-193.

 

9. Gao H, Yan P, Zhang S, Huang H, Huang F, Sun T, Deng Q, Huang Q, Chen S, Ye K, Xu J*, Liu L*. Long-Term Dietary Alpha-Linolenic Acid Supplement Alleviates Cognitive Impairment Correlate with Activating Hippocampal CREB Signaling in Natural Aging Rats. MolNeurobiol. 2016, 53(7): 4772-4786.

 

10. Gao H, Yan P, Zhang S, Nie S, Huang F, Han H, Deng Q, Huang Q, Yang W, Wu H, Yao P, Ye K, Xu J*, Liu L*. Chronic alpha-linolenic acid treatment alleviates age-associated neuropathology: Roles of PERK/eIF2α signaling pathway. Brain Behav Immun. 2015.Epub ahead of print

 

11. Gao H, Wang D, Zhang S, Xu M, Yang W, Yan P, Liu Y, Luo X, Wu H, Yao P, Yan H, Liu L*. Roles of ROS mediated oxidative stress and DNA damage in 3-methyl-2-quinoxalin benzenevinylketo-1, 4-dioxide-induced immunotoxicity of Sprague–Dawley rats. RegulToxicol Pharm. 2015, 73(2): 587-594.

 

12. Gao H, Meng J, Xu M, Zhang S, Ghose B, Liu J, Yao P, Yan H, Wang D*, Liu L*. Serum Heat Shock Protein 70 Concentration in Relation to Polycystic Ovary Syndrome in a Non-Obese Chinese Population. PLoS ONE. 2013, 8(6): e67727.

 

13. Gao H, Meng J, Xing H, Nie S, Xu M, Zhang S, Jin Y, Sun T, Huang H, Zhang H, Wang D*, Liu L*. Association of heme oxygenase-1 with the risk of polycystic ovary syndrome in non-obese women. Hum Reprod. 2014, 29(5): 1058-1066.

 

14. Liu H, Zeng Q, Cui Y, Zhao L, Zhang L, Fu G, Hou C, Zhang S, Yu L, Jiang C, Wang Z, Chen X, Wang A*. The role of the IRE1 pathway in excessive iodide- and/or fluoride-induced apoptosis in Nthy-ori 3-1 cells in vitro. Toxicol Lett. 2014, 224(3): 341-348.

 

15. Liu H, Zeng Q, Cui Y, Yu L, Zhao L, Hou C, Zhang S, Zhang L, Fu G, Liu Y, Jiang C, Chen X, Wang A*. The effects and underlying mechanism of excessive iodide on excessive fluoride-induced thyroid cytotoxicity. Environ Toxicol Phar. 2014, 38(1): 332-340.