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王爱国

  • 中文简历English resume
  • 姓名:王爱国
  • 职务:二级教授,博士生导师,教育部新世纪优秀人才,劳动卫生与环境卫生学系副主任
  • 院系:劳动卫生与环境卫生学系
  • 地址:湖北省武汉市航空路13号 430030
  • 电话:
  • 邮箱:wangaiguo@mails.tjmu.edu.cn

王爱国,1982.09―1987.07 湖南医科大学卫生系,本科学历/学士学位。1989.09―1992.07 华中科技大学同济医学院公共卫生学院环境卫生学教研室硕士研究生,获医学硕士学位,导师陈学敏教授。1997.08―1999.10 德国Ulm大学博士研究生,获医学博士学位,导师Andreas Nüssler。自1987年7月参加工作以来一直从事环境卫生学和环境毒理学的教学和科研工作。主要研究领域为外源性化合物的毒性作用及其分子机制研究,研究成果荣获湖北省自然科学奖一等奖和教育部自然科学奖二等奖。主要社会兼职有中国毒理学会第二届神经毒理专业委员会常务委员及中华医学会地方病学分会委员等。

 

 

主要负责的科研项目

1. 线粒体动力学改变在氟神经毒性中的作用及白藜芦醇干预效果研究(No. 81430076),2015.1-2019.12,国家自然科学基金重点项目,320.0万元,课题负责人

 

2. 自噬与凋亡在PBDE-47神经毒性中的作用研究(No. 81273021),2013.1-2016.12,国家自然科学基金面上项目,70.0万元,课题负责人

 

3. 内质网应激及UPR信号通路在PBDE-47神经毒性中的作用(No. 81072266),2011.1-2013.12,国家自然科学基金面上项目,34.0万元,课题负责人

 

4. 数字PET在环境污染物致神经毒性研究中的应用(No. 0118513100),华中科技大学2015年创新交叉重点团队自主创新基金,50.0万,课题负责人

 

 

代表性论著

1. Shun Zhang#, QiangNiu, Hui Gao, Rulin Ma, Rongrong Lei, Cheng Zhang, Tao Xia, Pei Li, Chunyan Xu, Chao Wang, Jingwen Chen, Lixing Dong, Qian Zhao, Aiguo Wang*. Excessive apoptosis and defective autophagy contribute to developmental testicular toxicity induced by fluoride. Environ Pollut. 2016, 212:97-104.

 

2. Shun Zhang#, Yihu Chen, Xue Wu, Hui Gao, Rulin Ma, Chunyang Jiang, Gang kuang, Guodong Zhao, Tao Xia, Xiaofei Zhang, Rongrong Lei, Cheng Zhang, Pei Li, Chunyan Xu, Aiguo Wang*. The Pivotal Role of Ca2+ Homeostasis in PBDE-47-Induced Neuronal Apoptosis.MolNeurobiol.2015 (Epub ahead of print).

 

3. Shun Zhang#, Xiaofei Zhang#, Hongliang Liu, Weidong , Zhizhong Guan, Qiang Zeng, Chunyang Jiang, Hui Gao, Cheng Zhang, Rongrong Lei, Tao Xia, Zhenglun Wang, Lu Yang, Yihu Chen, Xue Wu, Yushan Cui, Linyu Yu, and Aiguo Wang*. Modifying effect of COMT gene polymorphism and a predictive role for proteomics analysis in children’s intelligence in endemic fluorosis area in Tianjin, China.Toxicol Sci. 2015, 144(2):238-45.

 

4. Chunyang Jiang#, Shun Zhang#, Hongliang Liu, Zhizhong Guan, Qiang Zeng, Cheng Zhang, Rongrong Lei, Tao Xia, Zhenglun Wang, Lu Yang, Yihu Chen, Xue Wu, Xiaofei Zhang, Yushan Cui, Linyu Yu, Aiguo Wang*. Low Glucose Utilization and Neurodegenerative Changes Caused by Sodium Fluoride Exposure in Rat’s Developmental Brain.Neuromol Med. 2014, 16(1): 94-105.

 

5. Zhixia Xu#, Bayi Xu, Tao Xia, Weihong He, Ping Gao, LijuanGuo, Zhenglun Wang, QiangNiu, Aiguo Wang*.Relationship between intracellular Ca2+and ROS during fluoride-induced injury in SH-SY5Y cells.Environ Toxicol. 2013, 28(6):307-312.

 

6. Shun Zhang#, Chunyang Jiang#, Hongliang Liu, Zhizhong Guan, Qiang Zeng, Cheng Zhang, Rongrong Lei, Tao Xia, Hui Gao, Lu Yang, Yihu Chen, Xue Wu, Xiaofei Zhang, Yushan Cui, Linyu Yu, Zhenglun Wang, Aiguo Wang*. Fluoride-elicited developmental testicular toxicity in rats: Roles of endoplasmic reticulum stress and inflammatory response. ToxicolApplPharmacol. 2013, 271(2):206-215.

 

7. Shun Zhang#, Gang Kuang#, Guodong Zhao, Xue Wu, Cheng Zhang, Rongrong Lei, Tao Xia, Jianbin Chen, Zhenglun Wang,, Rulin Ma,, Bei Li,, Lu Yang, Aiguo Wang*. Involvement of the mitochondrial p53 pathway in PBDE-47-induced SH-SY5Y cells apoptosis and its underlying activation mechanism. Food ChemToxicol. 2013.62:699-706.

 

8. Chunyang Jiang#, Shun Zhang#, HongLiang Liu, Qiang Zeng, Tao Xia, Yihu Chen, Gang Kuang, Guodong Zhao, Xue Wu, Xiaofei Zhang, Aiguo Wang*. The role of the IRE1 pathway in PBDE-47-induced toxicity in human neuroblastoma SH-SY5Y cells in vitro.Toxicol Lett. 2012, 211(3):325-33.

 

9. QiangNiu#, HongLiang Liu, ZhiZhong Guan, Qiang Zeng, ShuXiaGuo, Ping He, LiJuanGuo, Ping Gao, BaYi Xu, ZhiXia Xu, Tao Xia, Aiguo Wang*. The Effect of c-Fos Demethylation on Sodium Fluoride-induced Apoptosis in L-02Cells.BiolTrace Elem Res. 2012, 149(1):102-9.

 

10. Bayi Xu#, Zhixia Xu, Tao Xia, Ping He, Ping Gao, Weihong He, Ming Zhang, LijuanGuo, QiangNiu, Aiguo Wang*. Effects of the Fas/Fas-L pathway on fluoride-induced apoptosis in SH-SY5Y cells.Environ Toxicol. 2011, 26(1):86-92.

 

11. Ping He#, Aiguo Wang*, QiangNiu, LijuanGuo, Tao Xia, Xuemin Chen.Toxic effect of PBDE-47 on thyroid development, learning, and memory, and the interaction between PBDE-47 and PCB153 that enhances toxicity in rats.Toxicol Ind Health. 2011, 27(3):279-88.